Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mee Whi Kim"'
Autor:
Ilya Bezprozvanny, Mee Whi Kim
Publikováno v:
Biochem Biophys Res Commun
Expansion of glutamine residue track (polyQ) within soluble protein is responsible for eight autosomal-dominant genetic neurodegenerative disorders. These disorders affect cerebellum, striatum, basal ganglia and other brain regions. Each disease deve
Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations
Autor:
Ilya Bezprozvanny, Mee Whi Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13600, p 13600 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer’s disease (AD). Sequential cleavage of APP by β and γ secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic
Autor:
Svetlana A. Korban, Mee Whi Kim, Vladimir Zhemkov, Dmitrii A. Luzik, Ilya Bezprozvanny, Alexandr Bolgov, Olga N. Rogacheva
Publikováno v:
Acta Crystallogr F Struct Biol Commun
This study presents the crystal structure of the N-terminal SH3 (SH3N) domain of growth factor receptor-bound protein 2 (Grb2) at 2.5 Å resolution. Grb2 is a small (215-amino-acid) adaptor protein that is widely expressed and involved in signal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef131c528858156a3375b58739c93fc6
https://europepmc.org/articles/PMC7278502/
https://europepmc.org/articles/PMC7278502/
Autor:
Vladimir Zhemkov, Alexey S. Melnikov, Shih Hao Su, Yuri A. Anufrikov, Sergey P. Tunik, Ilya Bezprozvanny, Anastasia I. Solomatina, Mee Whi Kim, Igor O. Koshevoy, Pi-Tai Chou, Pavel S. Chelushkin, Tatiana O. Abakumova, Vladislav V. Gurzhiy
Publikováno v:
Inorganic Chemistry. 58:204-217
This work describes interaction of a family of [Pt(N∧C)(PR3)Cl] complexes with imidazole (Im), possible application of this chemistry for regioselective labeling of proteins through imidazole rings of histidine residues and employment of the result
Differences in Recycling of Apolipoprotein E3 and E4—LDL Receptor Complexes—A Mechanistic Hypothesis
Autor:
Ilya Bezprozvanny, Mee Whi Kim
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5030, p 5030 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 5030, p 5030 (2021)
Apolipoprotein E (ApoE) is a protein that plays an important role in the transport of fatty acids and cholesterol and in cellular signaling. On the surface of the cells, ApoE lipoparticles bind to low density lipoprotein receptors (LDLR) that mediate
Publikováno v:
FEBS Open Bio
An expansion of polyglutamine (polyQ) sequence in ataxin-3 protein causes spinocerebellar ataxia type 3, an inherited neurodegenerative disorder. The crystal structure of the polyQ-containing carboxy-terminal fragment of human ataxin-3 was solved at
Autor:
Mahn Won Kim, Pieter A. J. de Witte, Theo Rasing, Abbas Rastegar, Mee Whi Kim, Irena Drevensek Olenik
Publikováno v:
Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals. 352:407-415
Oriented photopolymer films were obtained by using electric field alignment of the cinnamoyl side groups near the glass transition temperature of poly(vinyl)cinnamate (PVCN) followed by photo-polymerization using unpolarized UV light. In this way the
Autor:
Mee Whi Kim
Publikováno v:
Prion
Huntington disease is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine (polyQ) expansion (> 35Q) in the first exon (EX1) of huntingtin protein (Htt). mHtt protein is thought to adopt one or more toxic conformation(s) that ar
Summary Huntington's disease is a genetic neurodegenerative disorder resulting from polyglutamine (polyQ) expansion (>36Q) within the first exon of Huntingtin (Htt) protein. We applied X-ray crystallography to determine the secondary structure of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b1af044066c66a43c77c71ee5a21ac
https://europepmc.org/articles/PMC2863341/
https://europepmc.org/articles/PMC2863341/
Autor:
Mee Whi Kim
Publikováno v:
Molecular Neurodegeneration
Background: Polyglutamine (polyQ) repeat expansion within coding sequence of a soluble protein is responsible for eight autosomal-dominant genetic neurodegenerative disorders. These disorders affect cerebellum, striatum, basal ganglia and other brain