Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mee Ra Heo"'
Autor:
Robert P. Hayes, Mee Ra Heo, Mark Mason, John Reid, Christine Burlein, Kira A. Armacost, David M. Tellers, Izzat Raheem, Anthony W. Shaw, Edward Murray, Philip M. McKenna, Pravien Abeywickrema, Sujata Sharma, Stephen M. Soisson, Daniel Klein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Various herpesvirus therapeutics target the viral DNA polymerase. Here, the authors present the crystal structure of herpesvirus polymerase in the elongating state with bound primer-template DNA and the broad-spectrum non-nucleoside inhibitor PNU-183
Externí odkaz:
https://doaj.org/article/4bd96a2415b244b397a96da4a23966c4
Autor:
Daniel J. Klein, Philip M. McKenna, Pravien Abeywickrema, Stephen M. Soisson, Edward M. Murray, Sujata Sharma, David M. Tellers, Kira A. Armacost, Mee Ra Heo, Christine Burlein, John C. Reid, Anthony W. Shaw, Izzat T. Raheem, Robert P Hayes, Mark Mason
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature Communications
Nature Communications
All herpesviruses encode a conserved DNA polymerase that is required for viral genome replication and serves as an important therapeutic target. Currently available herpesvirus therapies include nucleoside and non-nucleoside inhibitors (NNI) that tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d03dc8f262babf43629a99b871bb6a6
https://doi.org/10.1038/s41467-021-23312-8
https://doi.org/10.1038/s41467-021-23312-8
Autor:
Xavier Fradera, Meredeth A. McGowan, Mangeng Cheng, Pravien Abeywickrema, Karin M. Otte, Prasanthi Geda, Nunzio Sciammetta, Catherine White, Konstanze von Köenig, Charles A. Lesburg, Hyun Chong Woo, Nadya Smotrov, Sarah E Trewick, Patrick J. Curran, Martin Augustin, Christine Andrews, Elizabeth Joshi, Wensheng Yu, Elliott B. Nickbarg, Phillip M. Cowley, Ian Knemeyer, Jongwon Lim, Hua Zhou, Yongxin Han, Xuelei Song, David Jonathan Bennett, Mee Ra Heo, Peter Spacciapoli, J. Richard Miller
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indoleamine-2,3-dioxygenase-1 (IDO1) has emerged as a target of significant interest to the field of cancer immunotherapy, as the upregulation of IDO1 in certain cancers has been linked to host immune evasion and poor prognosis for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581b064473f176e3696647f1e7fc716c
https://europepmc.org/articles/PMC7153270/
https://europepmc.org/articles/PMC7153270/
Autor:
Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann
Publikováno v:
SLAS Discovery. 22:995-1006
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e5ff95861fbde45cdff3f2132d673
https://doi.org/10.1177/2472555217706058
https://doi.org/10.1177/2472555217706058
Autor:
Steven S. Carroll, Jeffrey Heath, Antonella Converso, John M. Sanders, Tracy L. Diamond, Kartik Narayan, Mee Ra Heo, Mark W. Stahlhut, Triveni Bhatt, Min Xu, Daniel Krosky, Christine Burlein, Pravien Abeywickrema, Jay A. Grobler, Daniel J. Klein, Yangsi Ou, Gregory C. Adam, Cheng Wang, Sujata Sharma
Publikováno v:
ACS chemical biology. 12(11)
Allosteric integrase inhibitors (ALLINIs) bind to the lens epithelial-derived growth factor (LEDGF) pocket on HIV-1 integrase (IN) and possess potent antiviral effects. Rather than blocking proviral integration, ALLINIs trigger IN conformational chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbd532ce75aab6532455cdef64c2b52
https://pubmed.ncbi.nlm.nih.gov/29024587
https://pubmed.ncbi.nlm.nih.gov/29024587