Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mee J. Kim"'
Autor:
Ramon Y Birnbaum, Rupali P Patwardhan, Mee J Kim, Gregory M Findlay, Beth Martin, Jingjing Zhao, Robert J A Bell, Robin P Smith, Angel A Ku, Jay Shendure, Nadav Ahituv
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004592 (2014)
In addition to their protein coding function, exons can also serve as transcriptional enhancers. Mutations in these exonic-enhancers (eExons) could alter both protein function and transcription. However, the functional consequence of eExon mutations
Externí odkaz:
https://doaj.org/article/1bc49212af244252823c78c8dcedf49f
Autor:
Daniel S Evans, Melissa A Calton, Mee J Kim, Pui-Yan Kwok, Iva Miljkovic, Tamara Harris, Annemarie Koster, Yongmei Liu, Gregory J Tranah, Nadav Ahituv, Wen-Chi Hsueh, Christian Vaisse
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96805 (2014)
Common genetic variants 3' of MC4R within two large linkage disequilibrium (LD) blocks spanning 288 kb have been associated with common and rare forms of obesity. This large association region has not been refined and the relevant DNA segments within
Externí odkaz:
https://doaj.org/article/b4ff536cb28a467589273e32108d6217
Autor:
Ronald M. Krauss, Ba-Bie Teng, Yuanyuan Qin, Rosanne M. Crooke, Andréa C. Dosé, Zemin Yao, Jacob Strelnikov, Mohsen Amir Alipour, Marisa W. Medina, Mee J. Kim, Joseph Harmon, Feng Gao, Flora Ting
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, vol 40, iss 5
Arterioscler Thromb Vasc Biol
Arterioscler Thromb Vasc Biol
Objective: TMEM55B (transmembrane protein 55B) is a phosphatidylinositol-(4,5)-bisphosphate (PI[4,5]P 2 ) phosphatase that regulates cellular cholesterol, modulates LDLR (low-density lipoprotein receptor) decay, and lysosome function. We tested the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b00aa74b4d5405c9ef9f2cd1ff80a3a
https://escholarship.org/uc/item/3jh2c75s
https://escholarship.org/uc/item/3jh2c75s
Autor:
Hua Sun, Yuanyuan Qin, Marisa W. Medina, Ronald M. Krauss, Ba-Bie Teng, Joseph Harmon, Mee J. Kim, Flora Ting, Jacob Strelnikov, Andréa C. Dosé
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Upregulation of low density lipoprotein receptor (LDLR) activity reduces LDL levels and coronary disease risk. LDLR releases LDL in endosomes after internalization and then is either recycled to the cell surface or transported to lysosomes for decay.
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(5)
ABCG2 encodes the breast cancer resistance protein (BCRP), an efflux membrane transporter important in the detoxification of xenobiotics. In the present study, the basal activity of the ABCG2 promoter in liver, kidney, intestine, and breast cell line
Publikováno v:
Pharmacogenetics and genomics, vol 27, iss 12
Author(s): Eclov, Rachel J; Kim, Mee J; Chhibber, Aparna; Smith, Robin P; Ahituv, Nadav; Kroetz, Deanna L | Abstract: ObjectivesThe expression and activity of the breast cancer resistance protein (ABCG2) contributes toward the pharmacokinetics of end
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(2)
ABCG2 encodes the mitoxantrone resistance protein (MXR; breast cancer resistance protein), an ATP-binding cassette (ABC) efflux membrane transporter. Computational analysis of the ∼300 kb region of DNA surrounding ABCG2 (chr4:88911376-89220011, hg1
Autor:
Shoa L. Clarke, Loan Nguyen, Ramon Y. Birnbaum, Orly Agamy, Fiorella Gurrieri, Zachary Pappalardo, Gill Bejerano, Mee J. Kim, E. Josephine Clowney, Aaron M. Wenger, Jingjing Zhao, Charles E. Schwartz, David B. Everman, Stavros Lomvardas, Ohad S. Birk, Nadav Ahituv, Takayuki Yamanaka
Publikováno v:
Genome Research. 22:1059-1068
Enhancers are essential gene regulatory elements whose alteration can lead to morphological differences between species, developmental abnormalities, and human disease. Current strategies to identify enhancers focus primarily on noncoding sequences a
Autor:
Choli Lee, Robin P. Smith, Rupali P Patwardhan, Mee J. Kim, Jay Shendure, Joseph B. Hiatt, Len A. Pennacchio, Daniela Witten, Gregory M. Cooper, Dalit May, Jennifer M. Andrie, Su-In Lee, Nadav Ahituv
Publikováno v:
Nature biotechnology, vol 30, iss 3
Nature biotechnology
Nature biotechnology
The functional consequences of genetic variation in mammalian regulatory elements are poorly understood. We report the in vivo dissection of three mammalian liver enhancers at single nucleotide resolution via a massively parallelized reporter assay.
Autor:
Sook Wah Yee, Peter Skewes-Cox, Nadav Ahituv, Stephanie Hesselson, Hisayo Fukushima, Loan Nguyen, Jasmin L Eshragh, Susan J. Johns, Mee J. Kim, Laura B. Ramsey, Kathleen M. Giacomini, Thomas E. Ferrin, Mary V. Relling, Deanna L. Kroetz, Douglas Stryke, Pui-Yan Kwok, Richard A. Castro, Wen Cc
Publikováno v:
Clinical Pharmacology & Therapeutics. 89:571-578
Little is known about how genetic variations in enhancers influence drug response. In this study, we investigated whether nucleotide variations in enhancers that regulate drug transporters can alter their expression levels. Using comparative genomics