Escaping the cohort of concern: in vitro experimental evidence supports non-mutagenicity of N-nitroso-hydrochlorothiazide.

Autor: Gandhi RD; Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Hickert S; Merck KGaA, Darmstadt, Germany., Hoevelmann Y; Merck KGaA, Darmstadt, Germany., Mee CD; Gentronix Ltd. Alderley Park, Macclesfield, UK., Schlingemann J; Merck KGaA, Darmstadt, Germany. joerg.schlingemann@merckgroup.com., Adams A; Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK., Blanazs A; Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK., Simon S; Merck KGaA, Darmstadt, Germany., Elloway J; Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Rigger L; Reference Materials R&D, Merck KGaA, Buchs, Switzerland., Teasdale A; Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK., Beaumont CV; Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Wright L; Safety Sciences, R&D, AstraZeneca, Macclesfield, UK., Doherty A; Safety Sciences, R&D, AstraZeneca, Cambridge, UK.

Publikováno v: Archives of toxicology [Arch Toxicol] 2024 Dec; Vol. 98 (12), pp. 4159-4172. Date of Electronic Publication: 2024 Sep 11.

Rationally designing safer anilines: the challenging case of 4-aminobiphenyls.

Autor: Birch AM; AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, SK10 4TG, UK., Groombridge S, Law R, Leach AG, Mee CD, Schramm C

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2012 Apr 26; Vol. 55 (8), pp. 3923-33. Date of Electronic Publication: 2012 Apr 04.

Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.

Autor: Block MH; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom. Michael.Block@Astrazeneca.com, Boyer S, Brailsford W, Brittain DR, Carroll D, Chapman S, Clarke DS, Donald CS, Foote KM, Godfrey L, Ladner A, Marsham PR, Masters DJ, Mee CD, O'Donovan MR, Pease JE, Pickup AG, Rayner JW, Roberts A, Schofield P, Suleman A, Turnbull AV

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2002 Aug 01; Vol. 45 (16), pp. 3509-23.

Sensitivity of Salmonella typhimurium TA97a to the type of agar used for preparation of Vogel-Bonner plates.

Autor: Wilcox P; Glaxo Group Research Ltd., Ware, Hertfordshire, UK., Wedd DJ, Williams WR, Mee CD, O'Donovan MR

Publikováno v: Mutagenesis [Mutagenesis] 1992 Jan; Vol. 7 (1), pp. 13-8.

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