Discovery of the First Selective Nanomolar Inhibitors of Endoplasmic Reticulum Aminopeptidase 2 by Kinetic Target‐Guided Synthesis

Autor: Camberlein, Virgyl, Fleau-Tabey, Charlotte, Sierocki, Pierre, Li, Lenong, Gealageas, Ronan, Bosc, Damien, Guillaume, Valentin, Warenghem, Sandrine, Leroux, Florence, Rosell, Melissa, Cheng, Keguang, Medve, Laura, Prigent, Mathilde, Decanter, Myriam, Piveteau, Catherine, Biela, Alexandre, Eveque, Maxime, Dumont, Julie, Mpakali, Anastasia, Giastas, Petros, Herledan, Adrien, Couturier, Cyril, Haupenthal, Jörg, Lesire, Laetitia, Hirsch, Anna, Deprez, Benoit, Stratikos, Efstratios, Bouvier, Marlene, Deprez-Poulain, Rebecca

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2022, ⟨10.1002/anie.202203560⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4254::72a3eea8d473e79d675e83d7e0715cdb
https://hal.science/hal-03754065

Enhancing Potency and Selectivity of a DC‐SIGN Glycomimetic Ligand by Fragment‐Based Design: Structural Basis.

Autor: Medve, Laura¹ (AUTHOR), Achilli, Silvia² (AUTHOR), Guzman‐Caldentey, Joan³ (AUTHOR), Thépaut, Michel² (AUTHOR), Senaldi, Luca¹ (AUTHOR), Le Roy, Aline² (AUTHOR), Sattin, Sara¹ (AUTHOR), Ebel, Christine² (AUTHOR), Vivès, Corinne² (AUTHOR), Martin‐Santamaria, Sonsoles³ (AUTHOR) smsantamaria@cib.csic.es, Bernardi, Anna¹ (AUTHOR) anna.bernardi@unimi.it, Fieschi, Franck² (AUTHOR) franck.fieschi@ibs.fr

Publikováno v: Chemistry - A European Journal. 11/18/2019, Vol. 25 Issue 64, p14659-14668. 10p.

Modulators of hERAP2 discovered by High-Throughput Screening

Autor: Deprez Benoit, Charton Julie, Catherine Piveteau, Leroux Florence, van Endert Peter, Rosell Melissa, Deprez-Poulain Rebecca, Camberlein Virgyl, Guillaume Valentin, Castillo-Aguilera Omar, Dumont-Ryckembusch Julie, Warenghem Sandrine, Medve Laura, Fleau Charlotte, Bosc Damien, Gealageas Ronan, Lam Bao Vy

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2020, 211, pp.113053. ⟨10.1016/j.ejmech.2020.113053⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 211, pp.113053. ⟨10.1016/j.ejmech.2020.113053⟩

International audience; Endoplasmic reticulum aminopeptidase 2, ERAP2, is an emerging pharmacological target in cancer immunotherapy and control of autoinflammatory diseases, as it is involved in antigen processing. It has been linked to the risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757dddbe6404bcc4cec2bfba1545d382
https://hal.science/hal-03059990

[Untitled]

Autor: Medve, Laura, Achilli, Silvia, Serna, Sonia, Zuccotto, Fabio, Varga, Norbert, Thépaut, Michel, Civera, Monica, Vivès, Corinne, Fieschi, Franck, Reichardt, Niels, Bernardi, Anna

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (54), pp.14448-14460. ⟨10.1002/chem.201802577⟩
Chemistry-A European Journal, 2018, 24 (54), pp.14448-14460. ⟨10.1002/chem.201802577⟩
Chemistry (Weinheim an Der Bergstrasse, Germany)

International audience; A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cc5cafcc7d38f965450ba73c5573f9