Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Medizinische Fakultät » Universitätsklinikum Essen » Institut für Medizinische Strahlenbiologie"'
Publikováno v:
Cancers. 14(22)
OA Förderung 2022 BMN673 is a relatively new PARP inhibitor (PARPi) that exhibits superior efficacy in vitro compared to olaparib and other clinically relevant PARPi. BMN673, similar to most clinical PARPi, inhibits the catalytic activities of PARP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aba66910a8b26e680da8df2ecc3be8a
https://pubmed.ncbi.nlm.nih.gov/36428712
https://pubmed.ncbi.nlm.nih.gov/36428712
Autor:
Shan, Xu, Ali, Sak, Ben, Niedermaier, Yasin Bahadir, Erol, Michael, Groneberg, Emil, Mladenov, MingWei, Kang, George, Iliakis, Martin, Stuschke
ARID1A is frequently mutated in colorectal cancer (CRC) cells. Loss of ARID1A function compromises DNA damage repair and increases the reliance of tumor cells on ATR-dependent DNA repair pathways. Here, we investigated the effect of ionizing radiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fadaa317bb1d4cff1087cc529cd66d1
https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00077701/fonc_2022_12-999626.pdf
https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00077701/fonc_2022_12-999626.pdf
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7506
The intra-S-phase checkpoint was among the first reported cell cycle checkpoints in mammalian cells. It transiently slows down the rate of DNA replication after DNA damage to facilitate repair and thus prevents genomic instability. The ionizing radia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c419da7c7ed67abdbcf49843fd8438
https://duepublico2.uni-due.de/receive/duepublico_mods_00076669
https://duepublico2.uni-due.de/receive/duepublico_mods_00076669
Autor:
Huaping Xiao, Fanghua Li, Emil Mladenov, Aashish Soni, Veronika Mladenova, Bing Pan, Rositsa Dueva, Martin Stuschke, Beate Timmermann, George Iliakis
Publikováno v:
Cells; Volume 11; Issue 13; Pages: 2099
The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47234d0de6702883d76e157c228a5e2b
https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00076521/cells_2022-11-02099.pdf
https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00076521/cells_2022-11-02099.pdf
Autor:
Akram Hamidi, Alexandra Wolf, Rositsa Dueva, Melanie Kaufmann, Kirsten Göpelt, George Iliakis, Eric Metzen
Publikováno v:
Cells; Volume 11; Issue 10; Pages: 1671
The transcription factor hypoxia-inducible factor (HIF) is the main oxygen sensor which regulates adaptation to cellular hypoxia. The aim of this study was to establish cultured murine hepatocyte derived cells (mHDC) as an in vitro model and to analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9da467984b27f0f0913fc615cc6f5b
https://www.ncbi.nlm.nih.gov/pubmed/35626708
https://www.ncbi.nlm.nih.gov/pubmed/35626708
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
We previously reported that cells exposed to low doses of ionizing radiation (IR) in the G2-phase of the cell cycle activate a checkpoint that is epistatically regulated by ATM and ATR operating as an integrated module. In this module, ATR interphase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::86fe93f0f97a9192631165d1064dd2b8
http://link.springer.com/article/10.1038/s41598-019-51071-6
http://link.springer.com/article/10.1038/s41598-019-51071-6
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9180
OA Förderung 2022 In the cells of higher eukaryotes, sophisticated mechanisms have evolved to repair DNA double-strand breaks (DSBs). Classical nonhomologous end joining (c-NHEJ), homologous recombination (HR), alternative end joining (alt-EJ) and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995fb38a03778b43622e4d72d4969b5f
https://doi.org/10.3390/ijms23169180
https://doi.org/10.3390/ijms23169180
Publikováno v:
Life 11(6), 560 (2021). doi:10.3390/life11060560
Life
Life, Vol 11, Iss 560, p 560 (2021)
Life
Life, Vol 11, Iss 560, p 560 (2021)
Life 11(6), 560 (2021). doi:10.3390/life11060560
Published by MDPI, Basel
Published by MDPI, Basel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cead610aae65c138c83a036975ff579
Autor:
Magin, Simon, Georgoulis, Anastasios, Papadimitriou, Konstantinos, Iliakis, George, Vorgias, Constantinos E.
Here, the complete assembly of the Moritella marina MP-1 (ATCC 15381) genome, combining Illumina and long Nanopore reads, is presented. The gapless assembly consists of a 4.7-Mb circular chromosome and a 26-kb plasmid, with a G+C content of 40.7%, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d4a03317c1d01f587e194b2ffa8f5e36
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85079389076
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85079389076
Double strand breaks (DSBs) are induced in the DNA following exposure of cells to ionizing radiation (IR) and are highly consequential for genome integrity, requiring highly specialized modes of processing. Erroneous processing of DSBs is a cause of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______788::036611f639a296ba914fea8f49a8094b
https://duepublico2.uni-due.de/receive/duepublico_mods_00070836
https://duepublico2.uni-due.de/receive/duepublico_mods_00070836