Med1 controls thymic T-cell migration into lymph node through enhancer-based Foxo1-Klf2 transcription program.

Autor: Yuan N; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China., Su Y; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China., Gao Y; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China., Yang B; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China., Zhang T; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China., Wang Q; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China., Zhang D; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China., Shi L; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China., Jiao A; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China., Lei L; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China., Sun L; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China., Zhang B; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Basic and Translational Research Laboratory of Immune Related Diseases, Xi'an, Shaanxi Province, China.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 Oct; Vol. 54 (10), pp. e2350887. Date of Electronic Publication: 2024 Jul 27.

BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer.

Autor: Liu N; Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun 130061, China. Electronic address: nanliu@jlu.edu.cn., Wang S; Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun 130061, China., Li M; Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun 130061, China., Zhao N; Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun 130061, China., Wang D; Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun 130061, China., Zhang R; Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun 130061, China., Yu M; Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun 130061, China., Zhao L; Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun 130061, China., Zhang S; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130000, China., Han F; Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun 130061, China. Electronic address: fangbin.han@pksci.com., Zhao Y; Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun 130061, China. Electronic address: zhaoying0101@outlook.com., Liu Q; Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun 130061, China. Electronic address: liuquan1973@hotmail.com.

Publikováno v: Pharmacological research [Pharmacol Res] 2024 Oct; Vol. 208, pp. 107377. Date of Electronic Publication: 2024 Aug 28.

MED1, a novel binding partner of BRCA1, regulates homologous recombination and R-loop processing.

Autor: Honjoh H; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Tanikawa M; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan. michihiro.tanikawa@gmail.com., Wada-Hiraike O; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Oda K; Division of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Inaba H; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Kukita A; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Kawata Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Kusakabe M; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Tsuchimochi S; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Taguchi A; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Miyamoto Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Sone K; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Tsuruga T; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Mori-Uchino M; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Matsumoto Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan., Osuga Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113 8655, Japan.

Publikováno v: Scientific reports [Sci Rep] 2022 Oct 13; Vol. 12 (1), pp. 17140. Date of Electronic Publication: 2022 Oct 13.

MED1 Deficiency in Macrophages Aggravates Isoproterenol-Induced Cardiac Fibrosis in Mice.

Autor: Fatima M; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Gao J; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Han T; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China., Ding Y; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China., Zhang Y; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Wen E; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Jia L; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Wang R; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Wang W; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Zhao S; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Bai L; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China. Electronic address: bailiang0922@mail.xjtu.edu.cn., Liu E; Institute of Cardiovascular Science, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China. Electronic address: liuenqi@mail.xjtu.edu.cn.

Publikováno v: The American journal of pathology [Am J Pathol] 2022 Jul; Vol. 192 (7), pp. 1016-1027. Date of Electronic Publication: 2022 Apr 21.

Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.

Autor: Chaudhuri SM; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Weinberg SE; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wang D; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Yalom LK; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Montauti E; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Iyer R; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Tang AY; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Torres Acosta MA; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Shen J; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Mani NL; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wang S; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Liu K; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Lu W; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Bui TM; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Manzanares LD; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Dehghani Z; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wai CM; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Gao B; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wei J; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Yue F; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Cui W; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Singer BD; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Sumagin R; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Zhang Y; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Fang D; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: fangd@northwestern.edu.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Mar 19; Vol. 5 (3), pp. 101441. Date of Electronic Publication: 2024 Feb 29.