Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Medhi Wangpaichitr"'
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Glioblastoma is an aggressive brain cancer, usually of unknown etiology, and with a very poor prognosis. Survival from diagnosis averages only 3 months if left untreated and this only increases to 12–15 months upon treatment. Tr
Externí odkaz:
https://doaj.org/article/222c2913c9164cf8b68cb094bfbedce6
Autor:
Eric P. Knott, Emily Y. Kim, Edison Q. Kim, Rochelle Freire, Justin A. Medina, Yujie Wang, Cheng-Bang Chen, Chunjing Wu, Medhi Wangpaichitr, Jose R. Conejo-Garcia, Diane C. Lim
Publikováno v:
Cells, Vol 13, Iss 13, p 1120 (2024)
Understanding tumor–host immune interactions and the mechanisms of lung cancer response to immunotherapy is crucial. Current preclinical models used to study this often fall short of capturing the complexities of human lung cancer and lead to incon
Externí odkaz:
https://doaj.org/article/782ba5392931466f8bb9e186c1d42990
Autor:
Chunjing Wu, Sydney A. Spector, George Theodoropoulos, Dan J. M. Nguyen, Emily Y. Kim, Ashley Garcia, Niramol Savaraj, Diane C. Lim, Ankita Paul, Lynn G. Feun, Michael Bickerdike, Medhi Wangpaichitr
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Background The impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum resistance. We have identified crucial metabolic differences between cisplatin-resistant (CR) and ci
Externí odkaz:
https://doaj.org/article/a0383d87afed462586cb405c53f2010f
Autor:
Ying‐Ying Li, Chunjing Wu, Sumedh S. Shah, Shu‐Mei Chen, Medhi Wangpaichitr, Macus T. Kuo, Lynn G. Feun, Xiaoqing Han, Miguel Suarez, Jeffrey Prince, Niramol Savaraj
Publikováno v:
Molecular Oncology, Vol 11, Iss 12, Pp 1806-1825 (2017)
Melanomas harboring BRAF mutation (V600E) are known to recur frequently following treatment with BRAF inhibitors (BRAFi) despite a high initial response rate. Our previous study has uncovered that BRAFi‐resistant melanoma (BR) cells are vulnerable
Externí odkaz:
https://doaj.org/article/0ce0038e157442c390f27ac569a49769
Autor:
Medhi Wangpaichitr, George Theodoropoulos, Dan J. M. Nguyen, Chunjing Wu, Sydney A. Spector, Lynn G. Feun, Niramol Savaraj
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7379 (2021)
The development of drug resistance in tumors is a major obstacle to effective cancer chemotherapy and represents one of the most significant complications to improving long-term patient outcomes. Despite early positive responsiveness to platinum-base
Externí odkaz:
https://doaj.org/article/d6c5691817824ed88cb55b25b4f3efde
Autor:
Chunjing Wu, Min You, Dao Nguyen, Medhi Wangpaichitr, Ying-Ying Li, Lynn G. Feun, Macus T. Kuo, Niramol Savaraj
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7628 (2021)
Melanoma as a very aggressive type of cancer is still in urgent need of improved treatment. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and arginine deiminase (ADI-PEG20) are two of many suggested drugs for treating melanoma. Both
Externí odkaz:
https://doaj.org/article/4c46682104c2449fb3e2a193f6c0360a
Autor:
Shivank Bhatia, Keith Pereira, Prasoon Mohan, Govindarajan Narayanan, Medhi Wangpaichitr, Niramol Savaraj
Publikováno v:
Indian Journal of Radiology and Imaging, Vol 26, Iss 01, Pp 81-91 (2016)
Lung cancer continues to be one of the leading causes of death worldwide. In advanced cases of lung cancer, a multimodality approach is often applied, however with poor local control rates. In early non-small cell lung cancer (NSCLC), surgery is the
Externí odkaz:
https://doaj.org/article/882b6b14d2fb4ce6b33a065b64f00d78
Autor:
Chongxu Zhang, Tengjiao Cui, Renzhi Cai, Medhi Wangpaichitr, Mehdi Mirsaeidi, Andrew V. Schally, Robert M. Jackson
Publikováno v:
Cells, Vol 9, Iss 10, p 2331 (2020)
Growth hormone-releasing hormone (GHRH) is secreted primarily from the hypothalamus, but other tissues, including the lungs, produce it locally. GHRH stimulates the release and secretion of growth hormone (GH) by the pituitary and regulates the produ
Externí odkaz:
https://doaj.org/article/f68cd9c9a77243458748497e722c0500
Autor:
Niramol Savaraj, Chunjing Wu, Marcus Tien Kuo, Min You, Medhi Wangpaichitr, Carlos Robles, Seth Spector, Lynn Feun
Publikováno v:
Drug Target Insights, Vol 2, Pp 119-128 (2007)
It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melano
Externí odkaz:
https://doaj.org/article/fa24badab1a84ef38a70f6269131d41a
Autor:
Angkana Thongkum, Chunjing Wu, Ying-Ying Li, Medhi Wangpaichitr, Panida Navasumrit, Varabhorn Parnlob, Thaniya Sricharunrat, Vajarabhongsa Bhudhisawasdi, Mathuros Ruchirawat, Niramol Savaraj
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 6, p 1175 (2017)
Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC.
Externí odkaz:
https://doaj.org/article/a9f0d340849d4cfabbc3b4cf9180d1e7