Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Medhanie A. Mulaw"'
Autor:
Leiling Pan, Medhanie A. Mulaw, Johann Gout, Min Guo, Hina Zarrin, Peggy Schwarz, Bernd Baumann, Thomas Seufferlein, Martin Wagner, Franz Oswald
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 5, Pp 783-807 (2023)
Background and Aims: Development of pancreatic ductal adenocarcinoma (PDAC) is a multistep process intensively studied; however, precocious diagnosis and effective therapy still remain unsatisfactory. The role for Notch signaling in PDAC has been dis
Externí odkaz:
https://doaj.org/article/04e3fa24650a4a80b4d92d4f238b50c0
Autor:
Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism,
Externí odkaz:
https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a complex and dynamic network of interactions across multiple cell types regulates HSC function. During the last years, it became progressively clearer that changes in t
Externí odkaz:
https://doaj.org/article/71dd01893c4e48d89b3c3c1791c561a3
Autor:
Ani Grigoryan, Novella Guidi, Katharina Senger, Thomas Liehr, Karin Soller, Gina Marka, Angelika Vollmer, Yolanda Markaki, Heinrich Leonhardt, Christian Buske, Daniel B. Lipka, Christoph Plass, Yi Zheng, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-21 (2018)
Abstract Background The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and hi
Externí odkaz:
https://doaj.org/article/d09855951acf45d1acdccc0a55836829
Autor:
Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger, Kerstin Bartscherer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Some wounds trigger regeneration, while others simply heal but how this is regulated is unclear. Here, by manipulating ERK and Wnt signalling pathways, the authors create headless planarians and finless zebrafish and show that wounds that normally on
Externí odkaz:
https://doaj.org/article/e4121786dfd84d7e91076c345878d239
Autor:
Naidu M. Vegi, Josef Klappacher, Franz Oswald, Medhanie A. Mulaw, Amit Mandoli, Verena N. Thiel, Shiva Bamezai, Kristin Feder, Joost H.A. Martens, Vijay P.S. Rawat, Tamoghna Mandal, Leticia Quintanilla-Martinez, Karsten Spiekermann, Wolfgang Hiddemann, Konstanze Döhner, Hartmut Döhner, Hendrik G. Stunnenberg, Michaela Feuring-Buske, Christian Buske
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 498-507 (2016)
Homeobox genes are known to be key factors in leukemogenesis. Although the TALE family homeodomain factor Meis1 has been linked to malignancy, a role for MEIS2 is less clear. Here, we demonstrate that MEIS2 is expressed at high levels in patients wit
Externí odkaz:
https://doaj.org/article/568dc4d735944c92a3a29ec0ac42945f
Autor:
Julia K. Kühlwein, Wolfgang P. Ruf, Katharina Kandler, Simon Witzel, Christina Lang, Medhanie A. Mulaw, Arif B. Ekici, Jochen H. Weishaupt, Albert C. Ludolph, Veselin Grozdanov, Karin M. Danzer
Publikováno v:
Cellular and molecular life sciences 80(5), 131 (2023). doi:10.1007/s00018-023-04769-w
Amyotrophic Lateral Sclerosis (ALS) is a complex and incurable neurodegenerative disorder in which genetic and epigenetic factors contribute to the pathogenesis of all forms of ALS. The interplay of genetic predisposition and environmental footprints
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf37cb9a91825213956de9823b54d4e
Autor:
Mehmet, Saçma, Francesca, Matteini, Medhanie A, Mulaw, Ali, Hageb, Ruzhica, Bogeska, Vadim, Sakk, Angelika, Vollmer, Gina, Marka, Karin, Soller, Michael D, Milsom, Maria Carolina, Florian, Hartmut, Geiger
Publikováno v:
STAR protocols. 3(3)
Quantitative 3D imaging of organ-wide cellular and subcellular components is central for revealing and understanding complex interactions between stem cells and their microenvironment. Here, we present a gentle but fast whole-mount immunofluorescence
Autor:
Jeroen Bakkers, Teun P. de Boer, Mohankrishna Dalvoy Vasudevarao, Alberto Bertozzi, Medhanie A. Mulaw, Charlotte D. Koopman, Chi-Chung Wu, Phong D. Nguyen, Gilbert Weidinger
Publikováno v:
Developmental Biology. Academic Press
Adult zebrafish are frequently described to be able to "completely" regenerate the heart. Yet, the extent to which cardiomyocytes lost to injury are replaced is unknown, since existing evidence for cardiomyocyte proliferation is indirect or non-quant
Autor:
Andreas Bosio, Stella M. Davies, Hartmut Geiger, Cuiping Zhang, Rebekah Karns, Kalpana Nattamai, Sachin Kumar, Medhanie A. Mulaw, Akiko Shimamura, Ying Liang, Ute Bissels, Martha Luevano, Amanda Amoah, Kasiani C. Myers, Aishlin Hassan, M. Carolina Florian
Publikováno v:
Leukemia. 35:1751-1762
Shwachman-Diamond syndrome (SDS) is a bone marrow failure (BMF) syndrome associated with an increased risk of myelodysplasia and leukemia. The molecular mechanisms of SDS are not fully understood. We report that primitive hematopoietic cells from SDS