Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

Autor: Tammy J Bullwinkle, Noah M Reynolds, Medha Raina, Adil Moghal, Eleftheria Matsa, Andrei Rajkovic, Huseyin Kayadibi, Farbod Fazlollahi, Christopher Ryan, Nathaniel Howitz, Kym F Faull, Beth A Lazazzera, Michael Ibba

Publikováno v: eLife, Vol 3 (2014)

Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different

Externí odkaz: https://doaj.org/article/eb5a1ea56f6f4147a4307d8711e1ef96

Dual-function AzuCR RNA modulates carbon metabolism

Autor: Medha Raina, Jordan J. Aoyama, Shantanu Bhatt, Brian J. Paul, Aixia Zhang, Taylor B. Updegrove, Juan Miranda-Ríos, Gisela Storz

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(10)

Significance While most small, regulatory RNAs are thought to be “noncoding,” a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eced98d6b7c58c369d3cd05d2ffc33d
https://pubmed.ncbi.nlm.nih.gov/35239434

AzuCR RNA modulates carbon metabolism as a dual-function RNA inEscherichia coli

Autor: Medha Raina, Brian James Paul, Shantanu Bhatt, Gisela Storz, Jordan J Aoyama

Bacteria have evolved small RNAs (sRNAs) to regulate numerous biological processes and stress responses. While sRNAs generally are considered to be “noncoding”, a few have been found to also encode a small protein. Here we describe one such dual-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::559de79c6d8b462ea765febb63fa1a20
https://doi.org/10.1101/2021.04.27.441574

The Bacillus subtilis tyrZ Gene Encodes a Highly Selective Tyrosyl-tRNA Synthetase and Is Regulated by a MarR Regulator and T Box Riboswitch

Autor: Rebecca N. Williams-Wagner, Michael Ibba, Tina M. Henkin, Frank J. Grundy, Medha Raina

Misincorporation ofd-tyrosine (d-Tyr) into cellular proteins due to mischarging of tRNATyrwithd-Tyr by tyrosyl-tRNA synthetase inhibits growth and biofilm formation ofBacillus subtilis. Furthermore, manyB. subtilisstrains lack a functional gene encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5126dfd2d0f3398d96be5d9dd745ca
https://europepmc.org/articles/PMC4403656/

Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

Autor: Michael Ibba, Andrei Rajkovic, Tammy J. Bullwinkle, Eleftheria Matsa, Huseyin Kayadibi, Farbod Fazlollahi, Medha Raina, Christopher M. Ryan, Kym F. Faull, Adil Moghal, Noah M. Reynolds, Beth A. Lazazzera, Nathaniel Howitz

Publikováno v: eLife, vol 2014, iss 3
Bullwinkle, TJ; Reynolds, NM; Raina, M; Moghal, A; Matsa, E; Rajkovic, A; et al.(2014). Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code. ELIFE, 3. doi: 10.7554/eLife.02501. UCLA: Retrieved from: http://www.escholarship.org/uc/item/72v6p6sn
eLife
eLife, Vol 3 (2014)

Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced8bf0da5974003a51425762d487fd6
https://escholarship.org/uc/item/72v6p6sn