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Autor:
Stefan Kaden, Stefan Pabst, Jan Jaehrling, Mechthild Linnemann, Karin Felderer, Anne Höhne, Sebastian Jäger, Bodo Brocks, Daniela Daubert, Tobias Neuber, Thomas Tiller, Johanna Kölln, Ralf Ostendorp, Katrin Frese
Publikováno v:
mAbs. 6(4)
The neonatal Fc receptor (FcRn) protects immunoglobulin G (IgG) from degradation and increases the serum half-life of IgG, thereby contributing to a higher concentration of IgG in the serum. Because altered FcRn binding may result in a reduced or pro