Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Mechthild Hatzfeld"'
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110762- (2024)
Summary: The Hippo signaling pathway is an important regulator of organ growth and differentiation, and its deregulation contributes to the development of cancer. The activity of its downstream targets YAP/TAZ depends on adherens junctions. Plakophil
Externí odkaz:
https://doaj.org/article/af7ca01d2d374ae6a183ba0b27f5eb85
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/32c8650eb4da44e9853b453be3055b7b
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112031- (2023)
Summary: Plakophilin 3 (PKP3) is a component of desmosomes and is frequently overexpressed in cancer. Using keratinocytes either lacking or overexpressing PKP3, we identify a signaling axis from ERK to the retinoblastoma (RB) protein and the E2F1 tra
Externí odkaz:
https://doaj.org/article/466fc7e420614bb6b11f99253dcd7331
Autor:
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/fa3ce391f1f44f98982d03725da51593
Autor:
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)
Abstract Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent need. However, tumor
Externí odkaz:
https://doaj.org/article/2fab5abc84ca4a3daabdfded742fbe0b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them
Externí odkaz:
https://doaj.org/article/c2b3edb3f30048aea275ac827ed6218a
Autor:
Mechthild Hatzfeld, Thomas M. Magin
Publikováno v:
Journal of Investigative Dermatology. 142:272-274
Single gene disorders are ideally suited to establish robust genotype‒phenotype correlations and provide excellent opportunities to understand molecular pathomechanisms with relevance to complex disorders. The observation that patients diagnosed wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167d358a35859fc9010b508061378c8e
https://doi.org/10.1016/j.jid.2021.08.389
https://doi.org/10.1016/j.jid.2021.08.389
Autor:
Mechthild Hatzfeld, Monika Haemmerle, Markus Glaß, Tony Gutschner, Matthias Kappler, W.G. Ballhausen, Alexander W. Eckert, Lisa Müller, Jonas Weiße, Julia Rosemann, Danny Misiak, Stefan Hüttelmaier
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)
Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)
Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent need. However, tumors are com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faee6bd771212d0bc6e4e937b39443b4
http://europepmc.org/articles/PMC8194179
http://europepmc.org/articles/PMC8194179
Publikováno v:
Journal of Cell Science.
Desmosome remodeling is crucial for epidermal regeneration, differentiation and wound healing. It is mediated by adapting the composition and by posttranslational modifications of constituent proteins. We have previously demonstrated that plakophilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2546b962dc4dff055cc9b2970076935
https://doi.org/10.1242/jcs.238295
https://doi.org/10.1242/jcs.238295
Autor:
Amit Kumar, Mohanraj Gopalswamy, David J. Brockwell, Annika Wolf, Jochen Balbach, Mechthild Hatzfeld
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3344-3349
Significance Cell cycle progression is tightly controlled in healthy organisms and often perturbed in human diseases, including, most prominently, many forms of cancers. Cyclin-dependent protein kinases and their inhibitors, such as p19 INK4d , regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbae706028af141f20dfbfd176d11ac4
https://doi.org/10.1073/pnas.1719774115
https://doi.org/10.1073/pnas.1719774115