Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mechteld M. Grootte Bromhaar"'
Autor:
Sue McKay, Mechteld M. Grootte Bromhaar, Johan C. de Jongste, Henk C. Hoogsteden, Pramod R. Saxena, Hari S. Sharma
Publikováno v:
Mediators of Inflammation, Vol 10, Iss 3, Pp 135-142 (2001)
Background: Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation.
Externí odkaz:
https://doaj.org/article/e7bd38c01c84498f8e461ccc058d537f
Autor:
Mechteld M. Grootte Bromhaar, S. Adriaan Nelemans, Herman Meurs, Bart Vrugt, Johan Zaagsma, Dedmer Schaafsma, Reinoud Gosens
Publikováno v:
European Journal of Pharmacology, 494(1), 73-76. ELSEVIER SCIENCE BV
Growth factors have been implicated in the pathophysiology of asthma. However, the putative effects of these growth factors on human airway smooth muscle tone are still largely unknown. We performed contraction experiments using human bronchial smoot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5c4808fdc2f623cac1116389383c90
https://doi.org/10.1016/j.ejphar.2004.04.035
https://doi.org/10.1016/j.ejphar.2004.04.035
Autor:
Annet Tonkes, Herman Meurs, S. Adriaan Nelemans, Johan Zaagsma, Mechteld M. Grootte Bromhaar, Dedmer Schaafsma, Reinoud Gosens
Publikováno v:
British Journal of Pharmacology. 141:943-950
1. Airway smooth muscle (ASM) cells are known to switch from a contractile to a proliferative and synthetic phenotype in culture in response to serum and growth factors. Phenotype switching in response to contractile agonists, however, is poorly char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::935977c33d2d6b8e6843c7b946e9540d
https://doi.org/10.1038/sj.bjp.0705709
https://doi.org/10.1038/sj.bjp.0705709
Autor:
Mechteld M. Grootte Bromhaar, S. Adriaan Nelemans, Herman Meurs, Reinoud Gosens, Johan Zaagsma, Maartje Hiemstra
Publikováno v:
European Journal of Pharmacology, 481(1), 125-131. ELSEVIER SCIENCE BV
This study aims to investigate the effects of insulin on bovine tracheal smooth muscle phenotype in vitro. Contractility of muscle strips and DNA-synthesis ([3 H]thymidine incorporation) of isolated cells were used as parameters for smooth muscle phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6e1f024c7777fa0ea02f40de3d77a
https://research.rug.nl/en/publications/8f609d1a-20ec-48eb-94ed-cb4e41b2ec15
https://research.rug.nl/en/publications/8f609d1a-20ec-48eb-94ed-cb4e41b2ec15
Autor:
Sue McKay, Johan Zaagsma, Herman Meurs, S. Adriaan Nelemans, Reinoud Gosens, Mechteld M. Grootte Bromhaar
Publikováno v:
British Journal of Pharmacology. 137:459-466
1. The present study aims to investigate whether phenotypic changes, reported to occur in cultured isolated airway smooth muscle (ASM) cells, are of relevance to intact ASM. Moreover, we aimed to gain insight into the signalling pathways involved. 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c6dd2d9f3e35c3a6f43ff0f2e939297
https://doi.org/10.1038/sj.bjp.0704889
https://doi.org/10.1038/sj.bjp.0704889
Autor:
Hari S. Sharma, Henk C. Hoogsteden, Sue McKay, Johan C. de Jongste, Pramod R. Saxena, Mechteld M. Grootte Bromhaar
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 10, Iss 3, Pp 135-142 (2001)
Mediators of Inflammation, Vol 10, Iss 3, Pp 135-142 (2001)
Background: Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation.Aims: To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31781571aef90689e82bbc1f8bedc5b9
http://europepmc.org/articles/PMC1781705
http://europepmc.org/articles/PMC1781705
Autor:
Anita ten Damme, Herman Meurs, Johan Zaagsma, Reinoud Gosens, Harm Maarsingh, S. Adriaan Nelemans, Mechteld M. Grootte Bromhaar
Publikováno v:
European Journal of Pharmacology, 535(1-3), 253-262. ELSEVIER SCIENCE BV
This study aims to investigate the effects of bradykinin, alone and in combination with growth factors on proliferation of cultured bovine tracheal smooth muscle cells. Bradykinin did not induce mitogenic responses by itself, but concentration-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d113b0bc73684f882eb2b347a88cc025
https://pubmed.ncbi.nlm.nih.gov/16529737
https://pubmed.ncbi.nlm.nih.gov/16529737
Publikováno v:
European Journal of Pharmacology, 500(1-3), 193-201. ELSEVIER SCIENCE BV
Increased airway smooth muscle mass is a pathological feature that asthma and chronic obstructive pulmonary disease (COPD) have in common. This increase has gained renewed interest in view of recent developments showing that airway smooth muscle, ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bbb2a5f3101707fafa5b3da7863a6e
https://pubmed.ncbi.nlm.nih.gov/15464033
https://pubmed.ncbi.nlm.nih.gov/15464033
Autor:
Reinoud, Gosens, Mechteld M Grootte, Bromhaar, Annet, Tonkes, Dedmer, Schaafsma, Johan, Zaagsma, S Adriaan, Nelemans, Herman, Meurs
Publikováno v:
British journal of pharmacology. 141(6)
1. Airway smooth muscle (ASM) cells are known to switch from a contractile to a proliferative and synthetic phenotype in culture in response to serum and growth factors. Phenotype switching in response to contractile agonists, however, is poorly char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4796f863f712e26c7d94ddb0e03aaaef
https://pubmed.ncbi.nlm.nih.gov/14993104
https://pubmed.ncbi.nlm.nih.gov/14993104
Autor:
Mechteld M. Grootte Bromhaar, Herman Meurs, S. Adriaan Nelemans, Johan Zaagsma, Sue McKay, Reinoud Gosens
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology, 28(2), 257-262. AMER THORACIC SOC
Muscarinic receptor agonists have been considered to act synergistically in combination with growth facors on airway smooth muscle growth. Characterization of the proliferative responses and of the receptor subtype(s) involved has not yet been studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44186b9ceef8391e9f45dac3a2470ea
https://pubmed.ncbi.nlm.nih.gov/12540494
https://pubmed.ncbi.nlm.nih.gov/12540494