Multi-tissue proteogenomic analysis for mechanistic toxicology studies in non-model species

Autor: M.S. Lin, M.S. Varunjikar, K.K. Lie, L. Søfteland, L. Dellafiora, R. Ørnsrud, M. Sanden, M.H.G. Berntssen, J.L.C.M. Dorne, V. Bafna, J.D. Rasinger

Publikováno v: Environment International, Vol 182, Iss , Pp 108309- (2023)

New approach methodologies (NAM), including omics and in vitro approaches, are contributing to the implementation of 3R (reduction, refinement and replacement) strategies in regulatory science and risk assessment. In this study, we present an integra

Externí odkaz: https://doaj.org/article/1b9f8ec7e7b5439ca8460a7301fc16da

Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies [version 1; peer review: 2 approved]

Autor: Colin J. Henderson, C. Roland Wolf, Febe Ferro, Michael McMahon, Francisco Iñesta Vaquera

Publikováno v: F1000Research, Vol 11 (2022)

Chemical risk assessment ensures protection from the toxic effects of drugs and manmade chemicals. To comply with regulatory guidance, studies in complex organisms are required, as well as mechanistic studies to establish the relevance of any toxicit

Externí odkaz: https://doaj.org/article/e964a7dceca745aea0ecb59b8acb1ad2

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Models for integrating toxicology concepts into chemistry courses and programs

Autor: Amy S. Cannon, David Finster, Douglas Raynie, John C. Warner

Publikováno v: Green Chemistry Letters and Reviews, Vol 10, Iss 4, Pp 436-443 (2017)

Toxicology and related concepts are being taught within chemistry education programs to enable students to (1) develop an awareness of toxicological principles and concepts that are otherwise absent from the chemistry curriculum for undergraduates an

Externí odkaz: https://doaj.org/article/3735fc7dc9ee40389e9b20c2a0348601

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

Autor: Lola Bajard, Ondrej Adamovsky, Karine Audouze, Kirsten Baken, Robert Barouki, Joost B. Beltman, Anna Beronius, Eva Cecilie Bonefeld-Jørgensen, German Cano-Sancho, Milo L. de Baat, Filippo Di Tillio, Mariana F. Fernández, Rex E. FitzGerald, Claudia Gundacker, Antonio F. Hernández, Klara Hilscherova, Spyros Karakitsios, Eliska Kuchovska, Manhai Long, Mirjam Luijten, Sanah Majid, Philip Marx-Stoelting, Vicente Mustieles, Chander K. Negi, Dimosthenis Sarigiannis, Stefan Scholz, Iva Sovadinova, Rob Stierum, Shihori Tanabe, Knut Erik Tollefsen, Annick D. van den Brand, Carolina Vogs, Maria Wielsøe, Clemens Wittwehr, Ludek Blaha

Publikováno v: Environmental Research
Environmental Research. Elsevier BV
Bajard, L, Adamovsky, O, Audouze, K, Baken, K, Barouki, R, Beltman, J B, Beronius, A, Bonefeld-Jørgensen, E C, Cano-Sancho, G, de Baat, M L, Di Tillio, F, Fernández, M F, FitzGerald, R E, Gundacker, C, Hernández, A F, Hilscherova, K, Karakitsios, S, Kuchovska, E, Long, M, Luijten, M, Majid, S, Marx-Stoelting, P, Mustieles, V, Negi, C K, Sarigiannis, D, Scholtz, S, Sovadinova, I, Stierum, R, Tanabe, S, Tollefsen, K E, van den Brand, A D, Vogs, C, Wielsøe, M, Wittwehr, C & Blaha, L 2023, ' Application of AOPs to assist regulatory assessment of chemical risks-Case studies, needs and recommendations ', Environmental Research, vol. 217, 114650 . https://doi.org/10.1016/j.envres.2022.114650

While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1237a39508f13a4f75cb37a29540292