Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mechanistic Target of Rapamycin Complex 1/metabolism"'
Autor:
Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente
Publikováno v:
Nature Metabolism
Funding Information: The research in the M.P. laboratory was supported by the Max Planck Society, the European Research Council (ERC) Consolidator Grant EMERGE (no. 773047), the Deutsche Forschungsgemeinschaft (DFG, Project-ID 75732319 – SFB 834),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949e298d1cb95c83b830f240881e3703
https://doi.org/10.1038/s42255-022-00584-y
https://doi.org/10.1038/s42255-022-00584-y
Publikováno v:
Nature Communications. 13(1)
The protein kinase mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth and proliferation, supporting anabolic reactions and inhibiting catabolic pathways like autophagy. Its hyperactivation is a frequent event in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::c7015ff21183a55e9e73de884b7c95cd
https://doi.org/10.1038/s41467-022-32487-7
https://doi.org/10.1038/s41467-022-32487-7
Publikováno v:
Nature Communications. 13(1)
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::610fd571f5d2bc14e84fd609908b6f7a
https://hdl.handle.net/11370/c9d26e20-1728-4251-95ab-a03c61c26cca
https://hdl.handle.net/11370/c9d26e20-1728-4251-95ab-a03c61c26cca
Publikováno v:
Nature Communications. 13(1)
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___01423::a8983aee7e37f8f24e383ed9f44283a7
https://research.rug.nl/en/publications/c9d26e20-1728-4251-95ab-a03c61c26cca
https://research.rug.nl/en/publications/c9d26e20-1728-4251-95ab-a03c61c26cca
Autor:
Kaeser-Pebernard, Stephanie, Vionnet, Christine, Mari, Muriel, Sankar, Devanarayanan Siva, Hu, Zehan, Roubaty, Carole, Martinez-Martinez, Esther, Zhao, Huiyuan, Spuch-Calvar, Miguel, Petri-Fink, Alke, Rainer, Gregor, Steinberg, Florian, Reggiori, Fulvio, Dengjel, Joern
Publikováno v:
Kaeser-Pebernard, S, Vionnet, C, Mari, M, Sankar, D S, Hu, Z, Roubaty, C, Martínez-Martínez, E, Zhao, H, Spuch-Calvar, M, Petri-Fink, A, Rainer, G, Steinberg, F, Reggiori, F & Dengjel, J 2022, ' mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 ', Nature Communications, vol. 13, no. 1, 4685 . https://doi.org/10.1038/s41467-022-32487-7
Nature Communications, 13(1). Nature Publishing Group
Nature Communications, 13(1):4685. Nature Publishing Group
Nature Communications, 13(1). Nature Publishing Group
Nature Communications, 13(1):4685. Nature Publishing Group
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0b6a00518154df4ad35bfaf4aade0ea4
https://pure.au.dk/portal/da/publications/mtorc1-controls-golgi-architecture-and-vesicle-secretion-by-phosphorylation-of-scyl1(32310649-10bb-427b-934c-d6c8be6b1464).html
https://pure.au.dk/portal/da/publications/mtorc1-controls-golgi-architecture-and-vesicle-secretion-by-phosphorylation-of-scyl1(32310649-10bb-427b-934c-d6c8be6b1464).html
Autor:
Statzer, Cyril, Meng, Jin, Venz, Richard, Bland, Monet, Robida-Stubbs, Stacey, Patel, Krina, Petrovic, Dunja, Emsley, Raffaella, Liu, Pengpeng, Morantte, Ianessa, Haynes, Cole, Mair, William B., Longchamp, Alban, Filipovic, Milos R., Blackwell, T. Keith, Ewald, Collin Y.
Publikováno v:
Nature Communications, 13 (1)
Nature communications, vol. 13, no. 1, pp. 967
Nature communications, vol. 13, no. 1, pp. 967
Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex 1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses globally suppress protein synthesis through the integrated stress response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4246a715fccdce5a66d2f6df4fa1ab7
https://pubmed.ncbi.nlm.nih.gov/35181679
https://pubmed.ncbi.nlm.nih.gov/35181679
Autor:
Beatris Mastelic-Gavillet, Selena Vigano, Grégory Verdeil, Massimo Valerio, George Coukos, Haiping Wang, Rita Ahmed, Ping-Chih Ho, Laurent Derré, Nicolas Gestermann, Christine Ménétrier-Caux, Alexandre Harari, Camilla Jandus, Daniel E. Speiser, Blanca Navarro Rodrigo, Giuseppe Ercolano, Tu Nguyen-Ngoc, Patrice Jichlinski, Lana E. Kandalaft, Angela Ianaro, Leyder Elena Lozano, Pedro Romero, Christophe Caux, Thomas Tawadros, Olivier Dormond, Laure Décombaz
Publikováno v:
Journal for Immunotherapy of Cancer, Vol. 7, No 1 (2019) P. 257
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, vol. 7, no. 1, pp. 257
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, vol. 7, no. 1, pp. 257
Background Several mechanisms are present in the tumor microenvironment (TME) to impair cytotoxic T cell responses potentially able to control tumor growth. Among these, the accumulation of adenosine (Ado) contributes to tumor progression and represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5508c5e49d1ae61d46705579fe0472
https://archive-ouverte.unige.ch/unige:132568
https://archive-ouverte.unige.ch/unige:132568
Publikováno v:
Cell Death & Disease
Cell death & disease, vol. 7, no. 6, pp. e2242
Cell Death Discovery
Cell death & disease, vol. 7, no. 6, pp. e2242
Cell Death Discovery
Emergence of survival strategies is a key step for organisms during evolution. The capacity to adapt from nutrient-rich to nutrient-poor environments led to the appearance of protein complexes regulating anabolic and catabolic pathways. The evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca450d8c5024dd290c9ba311b681aa75
http://europepmc.org/articles/PMC5143383
http://europepmc.org/articles/PMC5143383