Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Mechanical microenvironment"'
Autor:
Tong Zhu, Zhaoyang Ye, Jingjing Song, Junjie Zhang, Yuxiang Zhao, Feng Xu, Jun Wang, Xin Huang, Bin Gao, Fei Li
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Extracellular matrix (ECM) stiffness is closely related to the progress of diabetic cardiomyopathy (DCM) and the response of treatment of DCM to anti-diabetic drugs. Dapagliflozin (Dapa) has been proven to have cardio-protective e
Externí odkaz:
https://doaj.org/article/b7abd5ff77cf4723ae689b74f164a479
Autor:
Yan Han, Zehua Shao, Yuanhao Zhang, Huan Zhao, Zirui Sun, Chaokuan Yang, Hao Tang, Yu Han, Chuanyu Gao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract This study investigates how dynamic fluctuations in matrix stiffness affect the behavior of cardiac fibroblasts (CFs) within a three-dimensional (3D) hydrogel environment. Using hybrid hydrogels with tunable stiffness, we created an in vitro
Externí odkaz:
https://doaj.org/article/cfca4ea9b61a44578d109b58e84df563
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 1069-1077 (2024)
The mechanical microenvironment plays a crucial regulatory role in the growth and development of cells. Mechanical stimuli, including shear, tensile, compression, and extracellular matrix forces, significantly influence cell adhesion, migration, prol
Externí odkaz:
https://doaj.org/article/ee50d25ad7274687afc712c2b8151a68
Autor:
Zheng Li, Yabo Zhu, Zhijie Zhang, Huimin Wang, Chong Wang, Chen Xu, Shiyou Li, Shuya Zhang, Xiangliang Yang, Zifu Li
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Aberrant tumor mechanical microenvironment (TMME), featured with overactivated cancer‐associated fibroblasts (CAFs) and excessive extracellular matrix (ECM), severely restricts penetration and accumulation of cancer nanomedicines, while mi
Externí odkaz:
https://doaj.org/article/3048920993cc43b39284eda2ea6e6aa5
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105200- (2024)
Summary: Nanoparticles have shown great potential for tumor targeting delivery via enhanced permeability and retention effect. However, the tumor mechanical microenvironment, characterized by dense extracellular matrix (ECM), high tumor stiffness and
Externí odkaz:
https://doaj.org/article/daaa0314ef7f44d99e0722310b9c26e4
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31162- (2024)
Biomechanical factors are strongly linked with the emergence and development of intervertebral disc degeneration (IVDD). The intervertebral disc (IVD), as a unique enclosed biomechanical structure, exhibits distinct mechanical properties within its s
Externí odkaz:
https://doaj.org/article/27c81f6a5e9a4a43a2e05311b04fe755
Autor:
Pan Zhang, Xu Zhao, Shiling Zhang, Guoliang Li, Adam C. Midgley, Yapeng Fang, Mouming Zhao, Katsuyoshi Nishinari, Xiaolin Yao
Publikováno v:
Current Research in Food Science, Vol 9, Iss , Pp 100865- (2024)
Cultivated meat (CM) provides a potential solution to meet the rising demand for eco-friendly meat supply systems. Recent efforts focus on producing CM that replicates the architecture and textural toughness of natural skeletal muscle. Significance o
Externí odkaz:
https://doaj.org/article/cd7c7fc9739248719d9de82c77a60204
Autor:
Zheng Zhang, Hongyuan Zhu, Guoqing Zhao, Yunyi Miao, Lingzhu Zhao, Jinteng Feng, Huan Zhang, Run Miao, Lin Sun, Bin Gao, Wencheng Zhang, Zheng Wang, Jianfang Zhang, Ying Zhang, Hui Guo, Feng Xu, Tian Jian Lu, Guy M. Genin, Min Lin
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract Dynamically evolving adhesions between cells and extracellular matrix (ECM) transmit time‐varying signals that control cytoskeletal dynamics and cell fate. Dynamic cell adhesion and ECM stiffness regulate cellular mechanosensing cooperativ
Externí odkaz:
https://doaj.org/article/0fe303bf95c7426797e33f65abbcb6db
Autor:
Timothy O. Josephson, Elise F. Morgan
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
At the macroscale, bones experience a variety of compressive and tensile loads, and these loads cause deformations of the cortical and trabecular microstructure. These deformations produce a variety of stimuli in the cellular microenvironment that ca
Externí odkaz:
https://doaj.org/article/694da2326ef84396b54cbfeeca305ad9
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