Zobrazeno 1 - 10
of 3 877
pro vyhledávání: '"Mechanical allodynia."'
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA recepto
Externí odkaz:
https://doaj.org/article/42431302e7c843399a5a0d1659566016
Autor:
Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Xi Zhang, Xian-Ying Cao, Xiao-Yu Tian, An-Nan Chen, Zi-Yi Chen, Yan Cao, Xiao Li, Xiao-Long Zhang
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-27 (2024)
Abstract Background Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is documented in the en
Externí odkaz:
https://doaj.org/article/3e91d3c1468d474ba4a868ec215d105d
Autor:
Loulwah Alothman, Emad Alhadlaq, Asma Alhussain, Alwaleed Alabdulkarim, Youssef Sari, Shakir D. AlSharari
Publikováno v:
Brain Sciences, Vol 14, Iss 11, p 1145 (2024)
Background/Objectives: Neuropathic pain is challenging to treat, often resistant to current therapies, and associated with significant side effects. Pregabalin, an anticonvulsant that modulates calcium channels, is effective but can impair mental and
Externí odkaz:
https://doaj.org/article/7160ec80f579477ab575db92bc8aee78
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common off-target adverse effects caused by various chemotherapeutic agents, such as cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib. CIPN is characterized by a substantial
Externí odkaz:
https://doaj.org/article/b1749322052b489da158713585bc0e0b
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α. This study aims to elucidate the
Externí odkaz:
https://doaj.org/article/53288813e39e423c92d6ad8903c7accb
Autor:
Shiho Shibata, Hideaki Tagashira, Takayuki Nemoto, Satomi Kita, Tomo Kita, Yasuharu Shinoda, Kouzaburo Akiyoshi, Ken Yamaura, Takahiro Iwamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 1, Pp 1-11 (2023)
Complex regional pain syndrome (CRPS) is an intractable chronic pain syndrome with various signs and symptoms including allodynia/hyperalgesia, edema, swelling, and skin abnormalities. However, a definitive therapeutic treatment for CRPS has not been
Externí odkaz:
https://doaj.org/article/f27089d75bbf4529a4d8ba03072f0a0d
Publikováno v:
Brain and Behavior, Vol 14, Iss 2, Pp n/a-n/a (2024)
Abstract Background Treating postherpetic neuralgia (PHN), which is characterized with a long‐lasting lancinating mechanical allodynia or hyperalgesia, is a big challenge as it is hard to achieve complete resolution. A synthetic triterpenoid, CDDO
Externí odkaz:
https://doaj.org/article/7cf56f144cbd4e0dbfc16d124c9dd38a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Oxaliplatin, a platinum-based chemotherapy drug, causes neuropathic pain, yet effective pharmacological treatments are lacking. Previously, we showed that tetrandrine (TET), with anti-inflammatory properties, reduces mechanical allodynia in nerve-inj
Externí odkaz:
https://doaj.org/article/1bdd8539f0d744f08e98d922482af058
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106381- (2024)
While neural oscillations play a critical role in sensory perception, it remains unclear how these rhythms function under conditions of neuropathic allodynia. Recent studies demonstrated that the anterior cingulate cortex (ACC) is associated with the
Externí odkaz:
https://doaj.org/article/8973a7c0550347e7a5afd8e534d54a6a
Autor:
Aryah Basu, Jennifer Y. Yang, Vasiliki E. Tsirukis, Andrew Loiacono, Gina Koch, Ishan A. Khwaja, Mahila Krishnamurthy, Nicholas Fazio, Emily White, Aayushi Jha, Shrila Shah, Cameron Takmil, Deniz Bagdas, Aylin Demirer, Adam Master, Ernest Natke, Robert Honkanen, Liqun Huang, Basil Rigas
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
BackgroundChemotherapy-induced peripheral neuropathy (CIPN), a side effect of chemotherapy, is particularly difficult to treat. We explored whether phosphosulindac (PS), a modified NSAID, could treat CIPN.MethodsCIPN was induced in male C57BL/6 J mic
Externí odkaz:
https://doaj.org/article/4b5cc8a234f5466895265552f5b013e4