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Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.

Autor: Mealka M; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Sierra NA; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Matteo DA; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Albekioni E; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Khoury R; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Mai T; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Conley BM; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Coleman NJ; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Sabo KA; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Komives EA; Department of Chemistry & Biochemistry, University of California San Diego, La Jolla, CA, USA., Bobkov AA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA USA., Cooksy AL; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Silletti S; Department of Chemistry & Biochemistry, University of California San Diego, La Jolla, CA, USA., Schiffer JM; Vividion Therapeutics, San Diego, CA, USA., Huxford T; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA., Sohl CD; Department of Chemistry & Biochemistry, San Diego State University, San Diego, CA, USA.

Publikováno v: Research square [Res Sq] 2024 Feb 23. Date of Electronic Publication: 2024 Feb 23.