The BACE1 product sAPPß induces ER stress and inflammation and impairs insulin signaling

Autor: Botteri G, Salvadó L, Gumà A, Lee Hamilton D, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer FX, Vazquez M

Publikováno v: METABOLISM-CLINICAL AND EXPERIMENTAL
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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OBJECTIVE: ß-secretase/ß-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a key enzyme involved in Alzheimer's disease that has recently been implicated in insulin-independent glucose uptake in myotubes. However, it is presently un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::93f9610eebff893300f526ec83cf8677
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13956

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Autor: Bell, KFS, Al-Mubarak, B, Martel, M-A, McKay, S, Wheelan, N, Hasel, P, Márkus, NM, Baxter, P, Deighton, RF, Serio, A, Bilican, B, Chowdhry, S, Meakin, PJ, Ashford, MLJ, Wyllie, DJA, Scannevin, RH, Chandran, S, Hayes, JD, Hardingham, GE

Publikováno v: Nature Communications
Bell, K F S, Al-Mubarak, B, Martel, M-A, McKay, S, Wheelan, N, Hasel, P, Márkus, N M, Baxter, P, Deighton, R F, Serio, A, Bilican, B, Chowdhry, S, Meakin, P J, Ashford, M L J, Wyllie, D J A, Scannevin, R H, Chandran, S, Hayes, J D & Hardingham, G E 2015, ' Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ', Nature Communications, vol. 6, 7066 . https://doi.org/10.1038/ncomms8066
Bell, K F S, Al-Mubarak, B, Martel, M-A, McKay, S, Wheelan, N, Hasel, P, Márkus, N M, Baxter, P, Deighton, R F, Serio, A, Bilican, B, Chowdhry, S, Meakin, P J, Ashford, M L J, Wyllie, D J A, Scannevin, R H, Chandran, S, Hayes, J D & Hardingham, G E 2015, ' Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. ', Nature Communications, vol. 6, pp. 7066 . https://doi.org/10.1038/ncomms8066

Forebrain neurons have weak intrinsic antioxidant defences compared with astrocytes, but the molecular basis and purpose of this is poorly understood. We show that early in mouse cortical neuronal development in vitro and in vivo, expression of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::05bb93a9969f51bb7c02e2cce6deadc2
http://europepmc.org/articles/PMC4441249

Targeting BACE1 to restore functional angiogenesis in type 2 diabetes.

Autor: Clavane, E, Cubbon, RM, Caolo, V, Meakin, PJ

Publikováno v: Cardiovascular Research; 2022 Supplement, Vol. 118, p1-1, 1p

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