A five-safes approach to a secure and scalable genomics data repository.

Autor: Shih CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Chen J; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Lee AS; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Bertin N; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Hebrard M; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore., Li Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Juan Tan JH; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Meah WY; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Peh SQ; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Mok SQ; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Sim KS; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Liu J; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Wang L; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Wong E; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Li J; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Tin A; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Singapore National Eye Centre, Singapore, Republic of Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Republic of Singapore., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Republic of Singapore., Saw SM; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore., Friedlander Y; Braun School of Public Health, Hebrew University of Jerusalem, Jerusalem, Israel., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore., Chong YS; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Republic of Singapore., Davila S; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Republic of Singapore., Goh LL; Molecular Diagnostic Laboratory, Tan Tock Seng Hospital, Singapore, Republic of Singapore., Lee ES; Clinical Research Unit, National Healthcare Group Polyclinics, Singapore, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Singapore National Eye Centre, Singapore, Republic of Singapore., Karnani N; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Republic of Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore., Leong KP; Personalised Medicine Service, Tan Tock Seng Hospital, Singapore, Republic of Singapore., Yeo KK; Duke-NUS Medical School, Singapore, Republic of Singapore.; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Republic of Singapore.; Department of Cardiology, National Heart Centre Singapore, Singapore, Republic of Singapore., Chambers JC; Precision Health Research, Singapore, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore.; School of Public Health, Imperial College London, London, UK., Lim SC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore.; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.; Diabetes Centre, Admiralty Medical Centre, Singapore, Republic of Singapore., Goh RSM; Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A∗STAR), 1 Fusionopolis Way, #16-16 Connexis (North Tower), Singapore 138632, Republic of Singapore., Tan P; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Precision Health Research, Singapore, Republic of Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore., Dorajoo R; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.

Publikováno v: IScience [iScience] 2023 Mar 31; Vol. 26 (4), pp. 106546. Date of Electronic Publication: 2023 Mar 31 (Print Publication: 2023).

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.

Autor: Li Z; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Wang Z; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Lee MC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Zenkel M; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Peh E; Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore., Ozaki M; Ozaki Eye Hospital, Miyazaki, Japan., Topouzis F; First Department of Ophthalmology, Faculty of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.; iScreen Research Team, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, Thessaloniki, Greece., Nakano S; Department of Ophthalmology, Faculty of Medicine, Oita University, Oita, Japan., Chan A; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Chen S; Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore., Williams SEI; Division of Ophthalmology, Department of Neurosciences, University of Witwatersrand, Johannesburg, South Africa., Orr A; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kobakhidze N; Chichua Medical Center Mzera, Tbilisi, Georgia., Zarnowski T; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Popa-Cherecheanu A; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.; Department of Ophthalmology, University Emergency Hospital, Bucharest, Romania., Mizoguchi T; Mizoguchi Eye Hospital, Nagasaki, Japan., Manabe SI; Hayashi Eye Hospital, Fukuoka, Japan., Hayashi K; Hayashi Eye Hospital, Fukuoka, Japan., Kazama S; Shinjo Eye Clinic, Miyazaki, Japan., Inoue K; Inouye Eye Hospital, Tokyo, Japan., Mori Y; Miyata Eye Hospital, Miyazaki, Japan., Miyata K; Miyata Eye Hospital, Miyazaki, Japan., Sugiyama K; Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Higashide T; Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Chihara E; Sensho-kai Eye Institute, Kyoto, Japan., Ideta R; Ideta Heisei Retina Consultants, Kumamoto, Japan., Ishiko S; Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan., Yoshida A; Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan., Tokumo K; Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, Japan., Kiuchi Y; Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, Japan., Ohashi T; Ohashi Eye Center, Sapporo, Japan., Sakurai T; Tane Memorial Eye Hospital, Osaka, Japan., Sugimoto T; Department of Ophthalmology, Miyazaki Medical College Hospital, Miyazaki, Japan., Chuman H; Department of Ophthalmology, Miyazaki Medical College Hospital, Miyazaki, Japan., Aihara M; Department of Ophthalmology, University of Tokyo, Tokyo, Japan., Inatani M; Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui, Japan., Mori K; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Gaston D; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Rafuse P; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada., Shuba L; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada., Saunders J; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada., Nicolela M; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada., Chichua G; Chichua Medical Center Mzera, Tbilisi, Georgia., Tabagari S; David Tvildiani Medical University, Tbilisi, Georgia., Founti P; First Department of Ophthalmology, Faculty of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.; Glaucoma Unit, Moorfields Eye Hospital NHS Foundation Trust, London, England., Sim KS; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Meah WY; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Soo HM; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Chen XY; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Chatzikyriakidou A; Laboratory of Medical Biology-Genetics, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Keskini C; First Department of Ophthalmology, Faculty of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Pappas T; First Department of Ophthalmology, Faculty of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Anastasopoulos E; First Department of Ophthalmology, Faculty of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Lambropoulos A; Laboratory of Medical Biology-Genetics, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Panagiotou ES; First Department of Ophthalmology, Faculty of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Mikropoulos DG; First Department of Ophthalmology, Faculty of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Kosior-Jarecka E; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Cheong A; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Li Y; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Lukasik U; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Nongpiur ME; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Husain R; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Perera SA; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Álvarez L; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., García M; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., González-Iglesias H; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Fernández-Vega Cueto A; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Fernández-Vega Cueto L; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Martinón-Torres F; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago and GENVIP Research Group, Instituto de Investigación Sanitaria, University of Santiago de Compostela, Santiago de Compostela, Spain., Salas A; Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigación Sanitaria, Hospital Clínico Universitario de Santiago, Galicia, Spain., Oguz Ç; Department of Genetics, Eskisehir Osmangazi University, Eskisehir, Turkey., Tamcelik N; Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Atalay E; Department of Ophthalmology, Eskisehir Osmangazi University, Eskisehir, Turkey., Batu B; Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Irkec M; Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Aktas D; DAMAGEN Genetic Diagnostic Center, Ankara, Turkey., Kasim B; Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Astakhov YS; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St Petersburg, Russia., Astakhov SY; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St Petersburg, Russia., Akopov EL; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St Petersburg, Russia., Giessl A; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mardin C; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Hellerbrand C; Institute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Cooke Bailey JN; Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio., Igo RP Jr; Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio., Haines JL; Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio., Edward DP; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago., Heegaard S; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Eye Pathology Section, Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Davila S; SingHealth Duke-NUS Institute of Precision Medicine, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore., Tan P; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; SingHealth Duke-NUS Institute of Precision Medicine, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Kang JH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Pasquale LR; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York., Kruse FE; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Reis A; Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany., Carmichael TR; Division of Ophthalmology, Department of Neurosciences, University of Witwatersrand, Johannesburg, South Africa., Hauser M; Department of Medicine, Duke University, Durham, North Carolina.; Department of Ophthalmology, Duke University, Durham, North Carolina., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa., Mossböck G; Department of Ophthalmology, Medical University Graz, Graz, Austria., Yildirim N; Department of Ophthalmology, Eskisehir Osmangazi University, Eskisehir, Turkey., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Konstas AGP; First and Third Departments of Ophthalmology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Coca-Prados M; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain.; Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut., Foo JN; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Kinoshita S; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Sotozono C; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kubota T; Department of Ophthalmology, Faculty of Medicine, Oita University, Oita, Japan., Dubina M; State Research Institute of Highly Pure Biopreparations FMBA Russia, St Petersburg, Russia., Ritch R; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York., Wiggs JL; Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston., Pasutto F; Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany., Schlötzer-Schrehardt U; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Ho YS; Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tam WL; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Nanyang Technological University School of Biological Sciences, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore.

Publikováno v: JAMA [JAMA] 2021 Feb 23; Vol. 325 (8), pp. 753-764.

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.

Autor: Foo JN; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Chew EGY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Chung SJ; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Peng R; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China., Blauwendraat C; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.; Data Tecnica International LLC, Glen Echo, Maryland., Mok KY; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, United Kingdom., Satake W; Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.; Department of Neurology, The University of Tokyo Graduate School of Medicine, Bunkyo, Tokyo, Japan., Toda T; Department of Neurology, The University of Tokyo Graduate School of Medicine, Bunkyo, Tokyo, Japan., Chao Y; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore., Tan LCS; Duke-National University of Singapore Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Tandiono M; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Lian MM; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Ng EY; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore., Prakash KM; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore., Au WL; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Meah WY; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Mok SQ; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Annuar AA; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Chan AYY; Margaret K. L. Cheung Research Centre for Management of Parkinsonism, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Prince of Wales Hospital, Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, PR China., Chen L; Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China., Chen Y; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China., Jeon BS; Department of Neurology, Seoul National University Hospital, Jongno-gu, Seoul, South Korea., Jiang L; Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China., Lim JL; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; Mah Pooi Soo and Tan Chin Nam Centre for Parkinson's and Related Disorders, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lin JJ; Department of Neurology, Chushang Show-Chwan Hospital, Zhushan District, Nantou, Taiwan., Liu C; Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, PR China., Mao C; Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, PR China., Mok V; Margaret K. L. Cheung Research Centre for Management of Parkinsonism, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Prince of Wales Hospital, Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, PR China., Pei Z; Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China., Shang HF; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China., Shi CH; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China., Song K; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, South Korea., Tan AH; Mah Pooi Soo and Tan Chin Nam Centre for Parkinson's and Related Disorders, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Wu YR; Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan., Xu YM; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China., Xu R; Department of Neurology, Jiangxi Provincial People's Hospital, Affiliated People's Hospital of Nanchang University, Nanchang, Jiangxi, PR China., Yan Y; Second Affiliated Hospital, Department of Neurology, Zhejiang University College of Medicine, Hangzhou, Zhejiang Province, PR China., Yang J; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China., Zhang B; Second Affiliated Hospital, Department of Neurology, Zhejiang University College of Medicine, Hangzhou, Zhejiang Province, PR China., Koh WP; Duke-National University of Singapore Medical School, Singapore, Singapore., Lim SY; Mah Pooi Soo and Tan Chin Nam Centre for Parkinson's and Related Disorders, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Khor CC; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore.; Singapore Eye Research Institute, Singapore, Singapore., Liu J; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Tan EK; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.

Publikováno v: JAMA neurology [JAMA Neurol] 2020 Jun 01; Vol. 77 (6), pp. 746-754.

Genome-Wide Analysis of Protein-Coding Variants in Leprosy.

Autor: Liu H; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; Shandong Provincial Medical Center for Dermatovenereology, Jinan, China., Wang Z; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Li Y; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore; Computational Sciences, The Jackson Laboratory, Farmington, Connecticut, USA., Yu G; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Fu X; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; School of Medicine, Shandong University, Jinan, China., Wang C; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Liu W; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Yu Y; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China., Bao F; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Irwanto A; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Liu J; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China., Chu T; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China., Andiappan AK; Singapore Immunology Network, Agency for Science, Technology and Research Singapore, Singapore., Maurer-Stroh S; Biomolecular Function Discovery Division, Bioinformatics Institute, A*STAR, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore., Limviphuvadh V; Biomolecular Function Discovery Division, Bioinformatics Institute, A*STAR, Singapore., Wang H; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; School of Medicine, Shandong University, Jinan, China., Mi Z; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Sun Y; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Sun L; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Wang L; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Wang C; Computational and Systems Biology, Genome Institute of Singapore, A*STAR, Singapore., You J; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China., Li J; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China., Foo JN; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Liany H; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Meah WY; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Niu G; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China., Yue Z; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; School of Medicine, Shandong University, Jinan, China., Zhao Q; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; School of Medicine, Shandong University, Jinan, China., Wang N; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; School of Medicine, Shandong University, Jinan, China., Yu M; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Yu W; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; School of Medicine and Life Science, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China., Cheng X; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; School of Medicine, Shandong University, Jinan, China., Khor CC; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Sim KS; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Aung T; Singapore National Eye Centre, Glaucoma Department, Singapore., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China., Wang D; Department of Otolaryngology, National University of Singapore, Singapore., Shi L; Department of Otolaryngology, the Second Affiliated Hospital, Shandong University, Jinan, China., Ning Y; Sichuan Provincial Institute of Dermatology, Sichuan, China., Zheng Z; Honghe Institute of Dermatology, Honghe, Yunnan, China., Yang R; Wenshan Institute of Dermatology, Wenshan, Yunnan, China., Li J; Guizhou Provincial Center for Disease Control and Prevention, Guizhou, China., Yang J; Yunnan Provincial Center for Disease Control and Prevention, Yunnan, China., Yan L; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Shen J; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Zhang G; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Chen S; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China., Liu J; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore., Zhang F; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China; Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, China; Shandong Provincial Medical Center for Dermatovenereology, Jinan, China; School of Medicine, Shandong University, Jinan, China; School of Medicine and Life Science, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China; National Clinical Key Project of Dermatology and Venereology, Jinan, China. Electronic address: zhangfuren@hotmail.com.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2017 Dec; Vol. 137 (12), pp. 2544-2551. Date of Electronic Publication: 2017 Aug 24.

Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.

Autor: Li Z; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Genome Institute of Singapore, Singapore., Xia Y; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Feng LN; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Chen JR; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Li HM; State Key Laboratory of Molecular Oncology, Beijing, China; Department of Etiology and Carcinogenesis, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, Beijing, China; Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Cui J; Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Cai QQ; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Sim KS; Genome Institute of Singapore, Singapore., Nairismägi ML; Lymphoma Genomic Translational Research Laboratory, National Cancer Centre Singapore, Singapore., Laurensia Y; Lymphoma Genomic Translational Research Laboratory, National Cancer Centre Singapore, Singapore., Meah WY; Genome Institute of Singapore, Singapore., Liu WS; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Guo YM; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Chen LZ; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Feng QS; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Chen LJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Chew SH; Department of Economics, National University of Singapore, Singapore., Ebstein RP; Department of Psychology, National University of Singapore, Singapore., Foo JN; Genome Institute of Singapore, Singapore., Liu J; Genome Institute of Singapore, Singapore., Ha J; Lymphoma Genomic Translational Research Laboratory, National Cancer Centre Singapore, Singapore., Khoo LP; Lymphoma Genomic Translational Research Laboratory, National Cancer Centre Singapore, Singapore., Chin ST; Lymphoma Genomic Translational Research Laboratory, National Cancer Centre Singapore, Singapore., Zeng YX; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Beijing Hospital, Beijing, China., Aung T; Singapore Eye Research Institute, Singapore., Chowbay B; Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore; Clinical Pharmacology, SingHealth, Singapore; Office of Clinical Sciences, Duke-National University of Singapore Medical School, Singapore., Diong CP; Department of Haematology, Singapore General Hospital, Singapore., Zhang F; Department of Pathology, Guangdong General Hospital, Guangzhou, China., Liu YH; Department of Pathology, Guangdong General Hospital, Guangzhou, China., Tang T; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Tao M; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Quek R; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Mohamad F; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Tan SY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore; Department of Pathology, Singapore General Hospital, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore; Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia; Department of Pathology, National University of Singapore, Singapore., Teh BT; Program in Cancer and Stem Cell Biology, Duke-National University of Singapore Medical School, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Ng SB; Department of Pathology, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pathology, National University Hospital, National University Health System, Singapore., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore., Ong CK; Lymphoma Genomic Translational Research Laboratory, National Cancer Centre Singapore, Singapore., Okada Y; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan., Raychaudhuri S; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Partners Center for Personalized Genetic Medicine, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Institute of Inflammation and Repair, University of Manchester, Manchester, UK; Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden., Lim ST; Lymphoma Genomic Translational Research Laboratory, National Cancer Centre Singapore, Singapore; Division of Medical Oncology, National Cancer Centre Singapore, Singapore; Office of Education, Duke-National University of Singapore Medical School, Singapore., Tan W; State Key Laboratory of Molecular Oncology, Beijing, China; Department of Etiology and Carcinogenesis, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, Beijing, China; Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Peng RJ; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Khor CC; Genome Institute of Singapore, Singapore; Singapore Eye Research Institute, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Bei JX; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Genome Institute of Singapore, Singapore; Center for Precision Medicine, Sun Yat-Sen University, Guangzhou, China. Electronic address: beijx@sysucc.org.cn.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2016 Sep; Vol. 17 (9), pp. 1240-7. Date of Electronic Publication: 2016 Jul 25.