Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Meaghan McGuinness"'
Autor:
Sara Canovas Nunes, Serena De Vita, Andrew Anighoro, François Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei Chen, Monika Ermann, David A. Williams, Haiming Xu
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 4, Pp 1-14 (2022)
Abstract RAS mutations prevalent in high-risk leukemia have been linked to relapse and chemotherapy resistance. Efforts to directly target RAS proteins have been largely unsuccessful. However, since RAS-mediated transformation is dependent on signali
Externí odkaz:
https://doaj.org/article/613d30b52a4c46d2b2f1029f01e33d73
Autor:
Christian Brendel, Olivier Negre, Michael Rothe, Swaroopa Guda, Geoff Parsons, Chad Harris, Meaghan McGuinness, Daniela Abriss, Alla Tsytsykova, Denise Klatt, Martin Bentler, Danilo Pellin, Lauryn Christiansen, Axel Schambach, John Manis, Helene Trebeden-Negre, Melissa Bonner, Erica Esrick, Gabor Veres, Myriam Armant, David A. Williams
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 589-600 (2020)
In this work we provide preclinical data to support initiation of a first-in-human trial for sickle cell disease (SCD) using an approach that relies on reversal of the developmental fetal-to-adult hemoglobin switch. Erythroid-specific knockdown of BC
Externí odkaz:
https://doaj.org/article/7ebf28bc3d664f328d3cea76508fe211
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/78ad0325a3e541ae99bcc4d9306f2f54
Autor:
Hiroto Horiguchi, Haiming Xu, Beatrice Duvert, Felicia Ciuculescu, Qiuming Yao, Amit Sinha, Meaghan McGuinness, Chad Harris, Christian Brendel, Anja Troeger, Roberto Chiarle, David A. Williams
Publikováno v:
Small GTPases. 13:267-281
Autor:
Hiroto, Horiguchi, Haiming, Xu, Beatrice, Duvert, Felicia, Ciuculescu, Qiuming, Yao, Amit, Sinha, Meaghan, McGuinness, Chad, Harris, Christian, Brendel, Anja, Troeger, Roberto, Chiarle, David A, Williams
Publikováno v:
Small GTPases
RHOH/TFF, a member of the RAS GTPase super family, has important functions in lymphopoiesis and proximal T cell receptor signalling and has been implicated in a variety of leukaemias and lymphomas. RHOH was initially identified as a translocation par
Autor:
Safa F Mohamad, Meaghan McGuinness, Gabriele Casirati, Alejo E Rodriguez-Fraticelli, Chad E. Harris, Fernando D. Camargo, Pietro Genovese, Eric J Allenspach, David A. Williams
Publikováno v:
Blood. 140:8588-8589
Autor:
Sara Canovas Nunes, Serena De Vita, Andrew Anighoro, François Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei Chen, Monika Ermann, David A. Williams, Haiming Xu
RAS mutations prevalent in high-risk leukemia have been linked to relapse and chemotherapy resistance. Efforts to directly target RAS proteins have been largely unsuccessful. However, since RAS-mediated transformation is dependent on signaling throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5afca98426fac549b096047a046be2
https://doi.org/10.1101/2022.03.14.484294
https://doi.org/10.1101/2022.03.14.484294
Autor:
Olivier Negre, Swaroopa Guda, Christian Brendel, Chad E. Harris, Martin Bentler, Myriam Armant, Melissa Bonner, Erica B. Esrick, John P. Manis, Helene Trebeden-Negre, Axel Schambach, Alla V. Tsytsykova, Danilo Pellin, Michael Rothe, Lauryn Christiansen, Denise Klatt, David A. Williams, Meaghan McGuinness, Daniela Abriss, Geoff Parsons, Gabor Istvan Veres
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 589-600 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
In this work we provide preclinical data to support initiation of a first-in-human trial for sickle cell disease (SCD) using an approach that relies on reversal of the developmental fetal-to-adult hemoglobin switch. Erythroid-specific knockdown of BC
Autor:
Boya Liu, Christian Brendel, Divya S. Vinjamur, Yu Zhou, Chad Harris, Meaghan McGuinness, John P. Manis, Daniel E. Bauer, Haiming Xu, David A. Williams
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 30(8)
A promising treatment for β-hemoglobinopathies is the de-repression of γ-globin expression leading to increased fetal hemoglobin (HbF) by targeting BCL11A. Here, we aim to improve a lentivirus vector (LV) containing a single BCL11A shmiR (SS) to fu
Publikováno v:
Haematologica. 105:e68-e71