Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Meaghan K. McGeary"'
Autor:
William Damsky, Alice Wang, Daniel J. Kim, Bryan D. Young, Katelyn Singh, Michael J. Murphy, Joseph Daccache, Abigale Clark, Ruveyda Ayasun, Changwan Ryu, Meaghan K. McGeary, Ian D. Odell, Ramesh Fazzone-Chettiar, Darko Pucar, Robert Homer, Mridu Gulati, Edward J. Miller, Marcus Bosenberg, Richard A. Flavell, Brett King
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Sarcoidosis is a heterogenous disorder often treated with glucocorticoids. Here the authors show, in an open label, non-randomized, single arm clinical trial involving 10 patients, that treatment with tofacitinib, a Janus kinase inhibitor, is associa
Externí odkaz:
https://doaj.org/article/d5af4834384540deaa82605bd13bb1ca
Autor:
Alice Wang, Alexander L. Fogel, Michael J. Murphy, Gauri Panse, Meaghan K. McGeary, Jennifer M. McNiff, Marcus Bosenberg, Matthew D. Vesely, Jeffrey M. Cohen, Christine J. Ko, Brett A. King, William Damsky
Publikováno v:
JID Innovations, Vol 1, Iss 2, Pp 100021- (2021)
Detection of individual cytokines in routine biopsies from patients with inflammatory skin diseases has the potential to personalize diagnosis and treatment selection, but this approach has been limited by technical feasibility. We evaluate whether a
Externí odkaz:
https://doaj.org/article/e2475c49a0464486a33048c4e52b75c5
Autor:
Meaghan K. McGeary, William Damsky, Andrew Daniels, Eric Song, Goran Micevic, Clotilde Huet-Calderwood, Hua Jane Lou, Sateja Paradkar, Susan Kaech, David A. Calderwood, Benjamin E. Turk, Akiko Iwasaki, Marcus W. Bosenberg
Publikováno v:
bioRxiv
SummaryDespite recent advances in the treatment of melanoma, many patients with metastatic disease still succumb to their disease. To identify tumor-intrinsic modulators of immunity to melanoma, we performed a whole-genome CRISPR screen in melanoma a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab6da168469da70fca196200a4ae76e
https://doi.org/10.1101/2023.05.23.541922
https://doi.org/10.1101/2023.05.23.541922
Autor:
Qin Yan, Marcus W. Bosenberg, Daniel P. Kelly, Matthew D. Hall, Anton Simeonov, Stephen C. Kales, Daniel J. Jansen, Ling Lai, Irina Krykbaeva, Meaghan K. McGeary, Shang-Min Zhang, Xiaoni Liu
Tumor heterogeneity is a major challenge for cancer treatment, especially due to the presence of various subpopulations with stem cell or progenitor cell properties. In mouse melanomas, both CD34+p75− (CD34+) and CD34−p75− (CD34−) tumor subpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067c56d0d5b3eb34e6f9c5b1dfc605d1
https://doi.org/10.1158/1535-7163.c.6538539.v1
https://doi.org/10.1158/1535-7163.c.6538539.v1
Autor:
Qin Yan, Marcus W. Bosenberg, Daniel P. Kelly, Matthew D. Hall, Anton Simeonov, Stephen C. Kales, Daniel J. Jansen, Ling Lai, Irina Krykbaeva, Meaghan K. McGeary, Shang-Min Zhang, Xiaoni Liu
Figure S1. Responses of different YUMM cell lines to BRAFi treatment; Figure S2. Inhibition of KDM5 family members by shRNA knockdown and pan-KDM5 inhibitors; Figure S3. Subpopulation composition in tumors of different volumes; Figure S4. In vivo BRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29b44f79f8fe1852f77e511980e40fd
https://doi.org/10.1158/1535-7163.22506975
https://doi.org/10.1158/1535-7163.22506975
Autor:
Shlomit Jessel, Wesley L. Cai, Xiaoni Liu, Kim Blenman, Carmen J. Booth, Marcus Bosenberg, Goran Micevic, Shang-Min Zhang, Yangyi Zhang, William Damsky, Harriet M. Kluger, Meaghan K. McGeary, Qin Yan, Jiesi Luo, Eric Song, Akiko Iwasaki, Durga Thakral, Mario Sznol, Mingzhu Yin, Lok Hei Chan, Lucia B. Jilaveanu
Publikováno v:
Nature. 598:682-687
Tumours use various strategies to evade immune surveillance1,2. Immunotherapies targeting tumour immune evasion such as immune checkpoint blockade have shown considerable efficacy on multiple cancers3,4 but are ineffective for most patients due to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c935e3b9c47ac6de523df0827385669c
https://doi.org/10.1038/s41586-021-03994-2
https://doi.org/10.1038/s41586-021-03994-2
Autor:
Alice Wang, Richard A. Flavell, Brett A. King, William Damsky, Meaghan K. McGeary, Marcus Bosenberg, Danielle Peterson, Michael J. Murphy, Austin McHenry, Nur-Taz Rahman
Publikováno v:
Journal of Allergy and Clinical Immunology. 147:1795-1809
Background Granuloma annulare (GA) is a common cutaneous inflammatory disorder characterized by macrophage accumulation and activation in skin. Its pathogenesis is poorly understood, and there are no effective treatments. The potential health implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6815d9ac892ab47fcd052b11c0dd42d
https://doi.org/10.1016/j.jaci.2020.10.012
https://doi.org/10.1016/j.jaci.2020.10.012
Autor:
Anjela Galan, William Damsky, Brett A. King, Meaghan K. McGeary, Jonathan S. Leventhal, Durga Thakral
Publikováno v:
Journal of the American Academy of Dermatology. 82:612-621
Background Sarcoidosis and granuloma annulare (GA) are cutaneous granulomatous disorders that can be difficult to treat. There is evidence of underlying Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway activation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a984938f548294810475ccabc0e32c
https://doi.org/10.1016/j.jaad.2019.05.098
https://doi.org/10.1016/j.jaad.2019.05.098
Publikováno v:
Journal of Evolutionary Biology. 33:629-641
Successful reproduction depends on interactions between numerous proteins beyond those involved directly in gamete fusion. Although such reproductive proteins evolve in response to sexual selection pressures, how networks of interacting proteins aris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e992ca5470ec025373af7271c5a69a
https://doi.org/10.1111/jeb.13597
https://doi.org/10.1111/jeb.13597
Autor:
Bryan D. Young, Edward J. Miller, Mridu Gulati, Changwan Ryu, Ramesh Fazzone-Chettiar, Meaghan K. McGeary, William Damsky, Marcus Bosenberg, Darko Pucar, Ruveyda Ayasun, Richard A. Flavell, Alice Wang, Brett A. King
Sarcoidosis is an idiopathic inflammatory disorder that is commonly treated with glucocorticoids and there are no approved steroid-sparing medications. There is emerging evidence that Janus kinase (JAK) inhibitors, which inhibit JAK-dependent cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2776d1b5f237f745fdca9a9a912395c6
https://doi.org/10.1101/2021.07.01.21259700
https://doi.org/10.1101/2021.07.01.21259700