Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Meaghan H Hancock"'
Autor:
Samuel Medica, Lindsey B Crawford, Michael Denton, Chan-Ki Min, Taylor A Jones, Timothy Alexander, Christopher J Parkins, Nicole L Diggins, Gabriel J Streblow, Adam T Mayo, Craig N Kreklywich, Patricia Smith, Sophia Jeng, Shannon McWeeney, Meaghan H Hancock, Andrew Yurochko, Michael S Cohen, Patrizia Caposio, Daniel N Streblow
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011682 (2023)
Human cytomegalovirus (HCMV) encodes multiple putative G protein-coupled receptors (GPCRs). US28 functions as a viral chemokine receptor and is expressed during both latent and lytic phases of virus infection. US28 actively promotes cellular migratio
Externí odkaz:
https://doaj.org/article/c4deb3fdeb3d4b18942e4ecdab4602f4
Autor:
Andrew H Pham, Jennifer Mitchell, Sara Botto, Kara M Pryke, Victor R DeFilippis, Meaghan H Hancock
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009380 (2021)
Human cytomegalovirus (HCMV) microRNAs (miRNAs) significantly rewire host signaling pathways to support the viral lifecycle and regulate host cell responses. Here we show that SMAD3 expression is regulated by HCMV miR-UL22A and contributes to the IRF
Externí odkaz:
https://doaj.org/article/f33fe872ec0342febd4b8131762b77cc
Autor:
Shunchuan Zhang, Lauren E Springer, Han-Zhi Rao, Renee G Espinosa Trethewy, Lindsey M Bishop, Meaghan H Hancock, Finn Grey, Christopher M Snyder
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009255 (2021)
Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for disseminating CMV f
Externí odkaz:
https://doaj.org/article/2f6f486f74ff4dc9bae97d0eadfcc6a2
Autor:
Iliyana Mikell, Lindsey B Crawford, Meaghan H Hancock, Jennifer Mitchell, Jason Buehler, Felicia Goodrum, Jay A Nelson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1007854 (2019)
Reactivation of latent Human Cytomegalovirus (HCMV) in CD34+ hematopoietic progenitor cells (HPCs) is closely linked to hematopoiesis. Viral latency requires maintenance of the progenitor cell quiescence, while reactivation initiates following mobili
Externí odkaz:
https://doaj.org/article/c5b0156f73024df2935fdfc37b1ec146
Autor:
Benjamin J Burwitz, Daniel Malouli, Benjamin N Bimber, Jason S Reed, Abigail B Ventura, Meaghan H Hancock, Luke S Uebelhoer, Amruta Bhusari, Katherine B Hammond, Renee G Espinosa Trethewy, Alex Klug, Alfred W Legasse, Michael K Axthelm, Jay A Nelson, Byung S Park, Daniel N Streblow, Scott G Hansen, Louis J Picker, Klaus Früh, Jonah B Sacha
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006014 (2016)
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and adaptation to their host, with no successful experimental cross-species infection in primates reported to date. Accordingly, full genome phylogenetic analysis of
Externí odkaz:
https://doaj.org/article/7f89ac2e54d24ee7a16db764f546ae92
Autor:
Nicole L. Diggins, Meaghan H. Hancock
Publikováno v:
Seminars in celldevelopmental biology.
Viruses have evolved a multitude of mechanisms to combat barriers to productive infection in the host cell. Virally-encoded miRNAs are one such means to regulate host gene expression in ways that benefit the virus lifecycle. miRNAs are small non-codi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5582de6f9ada35f99f17c375e3720e8
https://pubmed.ncbi.nlm.nih.gov/36463091
https://pubmed.ncbi.nlm.nih.gov/36463091
Autor:
Scott G. Hansen, Meaghan H. Hancock, Daniel Malouli, Emily E. Marshall, Colette M. Hughes, Kurt T. Randall, David Morrow, Julia C. Ford, Roxanne M. Gilbride, Andrea N. Selseth, Renee Espinosa Trethewy, Lindsey M. Bishop, Kelli Oswald, Rebecca Shoemaker, Brian Berkemeier, William J. Bosche, Michael Hull, Lorna Silipino, Michael Nekorchuk, Kathleen Busman-Sahay, Jacob D. Estes, Michael K. Axthelm, Jeremy Smedley, Danica Shao, Paul T. Edlefsen, Jeffrey D. Lifson, Klaus Früh, Jay A. Nelson, Louis J. Picker
Publikováno v:
Sci Immunol
The strain 68-1 rhesus cytomegalovirus (RhCMV)–based vaccine for simian immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV challenge by arresting viral replication early in primary infection. This vaccine elicits un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0029e764e7ae4b9f7d96198478afd222
https://europepmc.org/articles/PMC9387538/
https://europepmc.org/articles/PMC9387538/
Autor:
Nicole L, Diggins, Lindsey B, Crawford, Meaghan H, Hancock, Jennifer, Mitchell, Jay A, Nelson
Publikováno v:
mBio
Each herpesvirus family establishes latency in a unique cell type. Since herpesviruses genomes are maintained as episomes, the viruses need to devise mechanisms to retain the latent genome during cell division.
Human cytomegalovirus (HCMV) micro
Human cytomegalovirus (HCMV) micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e1755471f5bc2beb52e8a390496d9e7
https://pubmed.ncbi.nlm.nih.gov/33824207
https://pubmed.ncbi.nlm.nih.gov/33824207
Autor:
Meaghan H. Hancock, Jay A. Nelson, Nicole L. Diggins, Lindsey B. Crawford, Jennifer M. Mitchell
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Human cytomegalovirus (HCMV) microRNAs play essential roles in latency and reactivation in CD34+ hematopoietic progenitor cells (HPCs) via regulation of viral and cellular gene expression. In the present study, we show that HCMV miR-US25-1 targets Rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dc737bb1841a4b4392c69f64d168dc
https://journals.asm.org/doi/10.1128/mBio.00621-21
https://journals.asm.org/doi/10.1128/mBio.00621-21
Autor:
Nicole L, Diggins, Lindsey B, Crawford, Hillary M, Struthers, Lauren M, Hook, Igor, Landais, Rebecca L, Skalsky, Meaghan H, Hancock
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2244
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to sites within the 3' untranslated regions of messenger RNA (mRNA) transcripts. The discovery of this completely new mechanism of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13b95f63d845c60c614c8f971afb7336
https://pubmed.ncbi.nlm.nih.gov/33555594
https://pubmed.ncbi.nlm.nih.gov/33555594