Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Meaghan, Flagg"'
Autor:
Manmeet Singh, Kerry Goldin, Meaghan Flagg, Brandi N Williamson, Tessa Lutterman, Brian Smith, Emmie de Wit
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 10, p e0012635 (2024)
Nipah virus (NiV) is a highly pathogenic Paramyxovirus associated with outbreaks in Malaysia, Bangladesh, and India with high mortality rates. NiV infection causes fatal respiratory and neurological disease. The majority of survivors suffer from long
Externí odkaz:
https://doaj.org/article/c3716eecc7bb484c80dee558076243cd
Autor:
Meaghan Flagg, Kerry Goldin, Lizzette Pérez-Pérez, Manmeet Singh, Brandi N. Williamson, Nathanael Pruett, Chuong D. Hoang, Emmie de Wit
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
There is tremendous heterogeneity in the severity of COVID-19 disease in the human population, and the mechanisms governing the development of severe disease remain incompletely understood. The emergence of SARS-CoV-2 variants of concern (VOC) Delta
Externí odkaz:
https://doaj.org/article/ec540c177e954033983095d97fb37a3b
Autor:
Upasana Das Adhikari, Palak V. Shah, Leah M. Froehle, Alice H. Linder, Meaghan Flagg, Crystal Rawlings, Muntsa R. Junca, Lilian Folarin, Farina Karim, Jonathan Li, Henrik Kloverpris, Douglas S. Kwon
CD8+ tissue-resident memory T cells (CD8+ TRM) play an important role in mediating immune responses against HIV in the gastrointestinal (GI) mucosa. Antiretroviral therapy (ART) successfully supresses HIV replication in the blood, but fails to restor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff5c024551f63076407f0535ba4f12fa
https://doi.org/10.1101/2023.05.02.539176
https://doi.org/10.1101/2023.05.02.539176
Autor:
Douglas S. Kwon, Seyed Alireza Rabi, Richard A. Hodin, Laura E. Avena, Anthony Griffiths, Meaghan Flagg, James R. Stone, Manish Chandra Choudhary, Isabella Gomez, Derek J. Erstad, Virginia A. Triant, Ömer H. Yilmaz, George Eng, Mara Farcasanu, Larance Ronsard, Grace C. Lee, Daniel Lingwood, George C. Velmahos, Thomas J. Diefenbach, Upasana Das Adhikari, Anna N. Honko, Leah M Froehle, Abigail E. Schiff, Jonathan Z. Li
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
The clinical significance of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal tract, assessed by the presence of SARS-CoV-2 RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffc54379a50f5cce6631549f3f18049
https://doi.org/10.1093/cid/ciab623
https://doi.org/10.1093/cid/ciab623
Autor:
Emily Speranza, Jyothi N Purushotham, Julia R Port, Benjamin Schwarz, Meaghan Flagg, Brandi N Williamson, Friederike Feldmann, Manmeet Singh, Lizzette Pérez-Pérez, Gail L Sturdevant, Lydia M Roberts, Aaron Carmody, Jonathan E Schulz, Neeltje van Doremalen, Atsushi Okumura, Jamie Lovaglio, Patrick W Hanley, Carl Shaia, Ronald N Germain, Sonja M Best, Vincent J Munster, Catharine M Bosio, Emmie de Wit
Publikováno v:
Life science alliance. 5(4)
Advanced age is a key predictor of severe COVID-19. To gain insight into this relationship, we used the rhesus macaque model of SARS-CoV-2 infection. Eight older and eight younger macaques were inoculated with SARS-CoV-2. Animals were evaluated using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccfc40b07da7533d9ffbbc7a517112a
https://pubmed.ncbi.nlm.nih.gov/35039442
https://pubmed.ncbi.nlm.nih.gov/35039442
Autor:
Jyothi N. Purushotham, Julia R Port, Manmeet Singh, Lydia M. Roberts, Jonathan E Schulz, Patrick W. Hanley, Catharine M. Bosio, Atsushi Okumura, Benjamin Schwarz, Gail L. Sturdevant, Brandi N. Williamson, Sonja M. Best, Lizzette Pérez-Pérez, Jamie Lovaglio, Friederike Feldmann, Ronald N. Germain, Emily Speranza, Aaron B. Carmody, Carl Shaia, Emmie de Wit, Vincent J. Munster, Meaghan Flagg, Neeltje van Doremalen
Advanced age is a key predictor of severe COVID-19. To gain insight into this relationship, particularly with respect to immune responses, we utilized the rhesus macaque model of SARS-CoV-2 infection. Two cohorts of eight older (16-23 years) and eigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726dae533f9e34fc120335482920f1bb
https://doi.org/10.1101/2021.09.08.459430
https://doi.org/10.1101/2021.09.08.459430
Autor:
Patrick W. Hanley, Myndi G. Holbrook, Neeltje van Doremalen, Emmie de Wit, Greg Saturday, Brian J. Smith, Vincent J. Munster, Brandi N. Williamson, Craig Martens, Jamie Lovaglio, Beniah Brumbaugh, Atsushi Okumura, Danielle R. Adney, Claude Kwe Yinda, Meaghan Flagg, Sarah L. Anzick, Lizzette Pérez-Pérez, Jonathan E Schulz, Manmeet Singh, Friederike Feldmann
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Science Advances
article-version (status) pre
article-version (number) 1
Science Advances
Description
SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 do not cause more severe disease in rhesus macaques.
The emergence of several SARS-CoV-2 variants has caused global concerns about increased transmissibility, increased pathogen
SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 do not cause more severe disease in rhesus macaques.
The emergence of several SARS-CoV-2 variants has caused global concerns about increased transmissibility, increased pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c411b91062bc2d7de7e25d391e056104
https://doi.org/10.1101/2021.05.07.443115
https://doi.org/10.1101/2021.05.07.443115
Autor:
Brittany A. Bowman, James M. Richter, Douglas S. Kwon, John J. Garber, Björn Corleis, Crystal A. Rawlings, Sarah W. Moore, Gregory S. Olson, Meaghan Flagg
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
γδ T cells predominate in the intestinal mucosa and help maintain gut homeostasis and mucosal immunity. Although HIV infection significantly alters these cells, what drives these perturbations is unclear. Growing evidence suggests that impaired int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918f24ea5cf6e9cebfd5ad4ba482fe3b
http://link.springer.com/article/10.1038/s41598-018-34576-4
http://link.springer.com/article/10.1038/s41598-018-34576-4
Autor:
Gregory S, Olson, Sarah W, Moore, James M, Richter, John J, Garber, Brittany A, Bowman, Crystal A, Rawlings, Meaghan, Flagg, Björn, Corleis, Douglas S, Kwon
Publikováno v:
Scientific Reports
γδ T cells predominate in the intestinal mucosa and help maintain gut homeostasis and mucosal immunity. Although HIV infection significantly alters these cells, what drives these perturbations is unclear. Growing evidence suggests that impaired int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05d7f2ca51c3e74d0bc76d165af6926d
https://pubmed.ncbi.nlm.nih.gov/30405182
https://pubmed.ncbi.nlm.nih.gov/30405182
Autor:
Peter J. Carolan, Meaghan Flagg, Emily N. Pond, Kathleen O. Stewart, Norman S. Nishioka, Manish Gala, Melanie P. Parziale, Madeline M. Schuck, Katherine K. Gilpin, Samantha M. Chin, Andrew T. Chan, Francis Colizzo, James M. Richter, Crystal A. Rawlings, Sanford D. Markowitz, Hemant K. Roy, Matthew L. Freedman, Hamed Khalili, John J. Garber, Curtis Huttenhower, David A. Drew, Vadim Backman, Molin Wang, Kyle Staller, Dmitriy Kedrin, Ginger L. Milne, Daniel C. Chung, Douglas S. Kwon
Publikováno v:
Trials
Background Although aspirin is recommended for the prevention of colorectal cancer, the specific individuals for whom the benefits outweigh the risks are not clearly defined. Moreover, the precise mechanisms by which aspirin reduces the risk of cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1fbc503dd4a99dee97c90b8869bf98
http://europepmc.org/articles/PMC5286828
http://europepmc.org/articles/PMC5286828