Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Meagan E. Sullender"'
Autor:
Yinxing Zhu, Meagan E. Sullender, Danielle E. Campbell, Leran Wang, Sanghyun Lee, Takahiro Kawagishi, Gaopeng Hou, Alen Dizdarevic, Philippe H. Jais, Megan T. Baldridge, Siyuan Ding
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Rotaviruses pose a significant threat to young children. To identify novel pro- and anti-rotavirus host factors, we performed genome-wide CRISPR/Cas9 screens using rhesus rotavirus and African green monkey cells. Genetic deletion of either S
Externí odkaz:
https://doaj.org/article/c27da01121eb448cb209bdcb794bd3ad
Autor:
Teressa M. Shaw, Devra Huey, Makky Mousa-Makky, Jared Compaleo, Kylie Nennig, Aadit P. Shah, Fei Jiang, Xueer Qiu, Devon Klipsic, Raymond R. R. Rowland, Igor I. Slukvin, Meagan E. Sullender, Megan T. Baldridge, Haichang Li, Cody J. Warren, Adam L. Bailey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide
Externí odkaz:
https://doaj.org/article/6e7bb8aedb52446288ced11b8dff371e
Autor:
Michael R. McAllaster, Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang, Meagan E. Sullender, L. David Sibley, Herbert W. Virgin
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTGenes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct and physiologically important cellular processes. Some functions of ATG genes are independent of their role in degradative autophagy. O
Externí odkaz:
https://doaj.org/article/ee73c35548d94fc394c27a7238cc9bbd
Autor:
Kendall R. Sanson, Ruth E. Hanna, Mudra Hegde, Katherine F. Donovan, Christine Strand, Meagan E. Sullender, Emma W. Vaimberg, Amy Goodale, David E. Root, Federica Piccioni, John G. Doench
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Genome-wide libraries for CRISPR knockout, interference, and activation have allowed the systemic interrogation of gene function. Here, the authors evaluate the Brunello CRISPRko library and introduce Dolcetto and Calabrese for CRISPRi and CRISPRa, r
Externí odkaz:
https://doaj.org/article/b2b3b6edfdcb4b859c371ceb1069d5c6
Autor:
Meagan E. Sullender, Linley R. Pierce, Mridula Annaswamy Srinivas, Stacey L. Crockett, Bria F. Dunlap, Rachel Rodgers, Lawrence A. Schriefer, Elizabeth A. Kennedy, Brittany M. Stewart, John G. Doench, Megan T. Baldridge, Robert C. Orchard
Publikováno v:
J Virol
Noroviruses are a leading cause of gastroenteritis worldwide, yet the molecular mechanisms of how host antiviral factors restrict norovirus infection are poorly understood. Here, we present a CRISPR activation screen that identifies mouse genes which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f03f77c585ba294e32b009f5ad006e3
https://doi.org/10.1128/jvi.00707-22
https://doi.org/10.1128/jvi.00707-22
Autor:
John G. Doench, Mudra Hegde, David E. Root, Katherine F Donovan, Christine Strand, Amy Goodale, Ruth E Hanna, Emma W Vaimberg, Meagan E Sullender, Kendall R Sanson, Federica Piccioni
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
The creation of genome-wide libraries for CRISPR knockout (CRISPRko), interference (CRISPRi), and activation (CRISPRa) has enabled the systematic interrogation of gene function. Here, we show that our recently-described CRISPRko library (Brunello) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5e41fbed42e7c5b7d7342f0248f0ae
https://doaj.org/article/b2b3b6edfdcb4b859c371ceb1069d5c6
https://doaj.org/article/b2b3b6edfdcb4b859c371ceb1069d5c6
Autor:
Seungmin Hwang, Herbert W. Virgin, Sibley Ld, Michael R. McAllaster, Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Meagan E Sullender
Genes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct cellular processes with significant physiologic importance. One of the first-described of these ATG gene-dependent processes is the requirement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5620eee3ad93f48556e60afad80134bb
https://doi.org/10.1101/2021.05.10.443539
https://doi.org/10.1101/2021.05.10.443539
Autor:
Tanel Mahlakõiv, Stefan T. Peterson, Laure Dumoutier, Ian E Gentle, Peter Staeheli, Celso A. Reis, Meagan E Sullender, Camille Michiels, Pedro P. Hernandez, Annette Ohnemus, Megan T. Baldridge, Stefania Crotta, Andreas Diefenbach, Andreas Wack, Daniel Schnepf
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0247738 (2021)
PLoS ONE
PloS one, Vol. 16, no.8, p. e0247738 (2021)
PLoS ONE
PloS one, Vol. 16, no.8, p. e0247738 (2021)
The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b108ae53167508f0d332d17c65e9b13
https://doi.org/10.1371/journal.pone.0247738
https://doi.org/10.1371/journal.pone.0247738
Autor:
Michael Field, Patrick M. Lombardi, Renana Rabe, Clement Oyeniran, Jozef Gecz, Jessica Jackson, Yu Zhao, Cathrine Broberg Vågbø, Geir Slupphaug, Meagan E Sullender, Cynthia Wolberger, Joshua R. Brickner, Jennifer M. Soll, Alessandro Vindigni, Elyse M Blazosky, Nima Mosammaparast, Mark A. Corbett, Andrea K. Byrum, Miranda C. Mudge
Publikováno v:
Nature
DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms for repairing several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b972036f271efca708c243af065814
https://doi.org/10.1038/nature24484
https://doi.org/10.1038/nature24484
Autor:
Meagan E Sullender, Linley Pierce, Rachel Rodgers, Lawrence Schriefer, Bria F Dunlap, John G Doench, Robert C Orchard, Megan T Baldridge
Publikováno v:
The Journal of Immunology. 206:20.35-20.35
Noroviruses (NoVs) are the leading cause of acute viral gastroenteritis worldwide, causing up to 700 million infections and 200,000 deaths annually, and treatment is limited to supportive care as there are currently no targeted antivirals nor vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94722205b1e62d397052cf275453a308
https://doi.org/10.4049/jimmunol.206.supp.20.35
https://doi.org/10.4049/jimmunol.206.supp.20.35