Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Meagan E, Ita"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Chronic joint pain is a major healthcare challenge with a staggering socioeconomic burden. Pain from synovial joints is mediated by the innervated collagenous capsular ligament that surrounds the joint and encodes nociceptive signals. The interstitia
Externí odkaz:
https://doaj.org/article/bfdb78821310484ba39d035dc45bafd4
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Degeneration is a hallmark of painful joint disease and is mediated by many proteases that degrade joint tissues, including collagenases. We hypothesized that purified bacterial collagenase would initiate nociceptive cascades in the joint by
Externí odkaz:
https://doaj.org/article/344c81ec75a94e67b683c5bfb1e94eab
Autor:
Meagan E. Ita, Beth A. Winkelstein
Publikováno v:
Frontiers in Mechanical Engineering, Vol 8 (2022)
Chronic joint pain is a major health problem that can result from abnormal loading of the innervated ligamentous capsule that surrounds synovial joints. The matrix metalloproteinases-1 (MMP-1) and MMP-9 are hypothesized pain mediators from stretch-in
Externí odkaz:
https://doaj.org/article/99e04d91400a4fa38e50fe8316cabcbf
Autor:
Ahmad Amirshaghaghi, Sonia Kartha, Lesan Yan, Lijun Luo, Zhiliang Cheng, Beth A. Winkelstein, Meagan E. Ita, Yulong Wei, Andrew Tsourkas
Publikováno v:
ACS Nano. 14:8103-8115
Treating persistent neuropathic pain remains a major clinical challenge. Current conventional treatment approaches carry a substantial risk of toxicity and provide only transient pain relief. In this work, we show that the activity and expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f1adeef5b4607c81933211e3a91015
https://doi.org/10.1021/acsnano.0c00999
https://doi.org/10.1021/acsnano.0c00999
Publikováno v:
Biomech Model Mechanobiol
In innervated collagenous tissues, tissue scale loading may contribute to joint pain by transmitting force through collagen fibers to the embedded mechanosensitive axons. However, the highly heterogeneous collagen structures of native tissues make un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b0936233058a8c55b3790fd466eb76
https://europepmc.org/articles/PMC9289994/
https://europepmc.org/articles/PMC9289994/
Publikováno v:
J Orthop Res
Orofacial pain is among the most common chronic pain conditions and can result from temporomandibular disorders (TMDs) of the temporomandibular joint (TMJ). Matrix metalloproteinases (MMPs) drive degeneration of TMJ tissues and likely mediate pain in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3110470cf05e5b59d99d9725004625c
https://europepmc.org/articles/PMC8484377/
https://europepmc.org/articles/PMC8484377/
Autor:
Sonia, Kartha, Lesan, Yan, Meagan E, Ita, Ahmad, Amirshaghaghi, Lijun, Luo, Yulong, Wei, Andrew, Tsourkas, Beth A, Winkelstein, Zhiliang, Cheng
Publikováno v:
ACS Nano
Treating persistent neuropathic pain remains a major clinical challenge. Current conventional treatment approaches carry a substantial risk of toxicity and provide only transient pain relief. In this work, we show that the activity and expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20a1eb0c8e8fc1c65f53a2dfaa06e480
https://pubmed.ncbi.nlm.nih.gov/32484651
https://pubmed.ncbi.nlm.nih.gov/32484651
Autor:
Meagan E. Ita, Beth A. Winkelstein
Publikováno v:
J Biomech Eng
Abnormal loading of a joint's ligamentous capsule causes pain by activating the capsule's nociceptive afferent fibers, which reside in the capsule's collagenous matrix alongside fibroblast-like synoviocytes (FLS) and transmit pain to the dorsal root
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cf57ab92978f5f2d2165e972d2b601
https://doi.org/10.1115/1.4044051
https://doi.org/10.1115/1.4044051
Autor:
Lesan Yan, Vladimir V. Shuvaev, Christine L. Weisshaar, Beth A. Winkelstein, Vladimir R. Muzykantov, Zhiliang Cheng, Meagan E. Ita, Andrew Tsourkas, Sonia Kartha
A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3731ce8662bf94514427fe6ec5374d4
https://europepmc.org/articles/PMC5591629/
https://europepmc.org/articles/PMC5591629/
Publikováno v:
The Journal of orthopaedic and sports physical therapy. 47(7)
Synopsis Chronic neck pain is a common condition and a primary clinical symptom of whiplash and other spinal injuries. Loading-induced neck injuries produce abnormal kinematics between the vertebrae, with the potential to injure facet joints and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0885e71612a2c8d02f68cc14fee22f
https://pubmed.ncbi.nlm.nih.gov/28622486
https://pubmed.ncbi.nlm.nih.gov/28622486