Zobrazeno 1 - 10
of 50
pro vyhledávání: '"MeCP2 isoforms"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4218 (2023)
DNA methylation, one of the most well-studied epigenetic modifications, is involved in a wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology and function. Such regulatory mechanisms involve histone modifications,
Externí odkaz:
https://doaj.org/article/80b71455882b49b4a334b01988e7f42a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15643 (2022)
Methyl CpG binding protein 2 (MeCP2) is an epigenetic reader that binds to methylated CpG dinucleotides and regulates gene transcription. Mecp2/MECP2 gene has 4 exons, encoding for protein isoforms MeCP2E1 and MeCP2E2. MeCP2 plays key roles in neurod
Externí odkaz:
https://doaj.org/article/4581e0d53b7f4bd6b6136ef1ee4e1f07
Akademický článek
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Autor:
Mojgan Rastegar, Dag H. Yasui
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/5c0db84a2c70403a9cea49e26e1ac9ae
Autor:
Marjorie Buist, Nada El Tobgy, Danilo Shevkoplyas, Matthew Genung, Annan Ali Sher, Shervin Pejhan, Mojgan Rastegar
Publikováno v:
Cells, Vol 11, Iss 9, p 1442 (2022)
Eukaryotic gene expression is controlled at multiple levels, including gene transcription and protein translation initiation. One molecule with key roles in both regulatory mechanisms is methyl CpG binding protein 2 (MeCP2). MECP2 gain- and loss-of-f
Externí odkaz:
https://doaj.org/article/5bdb92bdafeb4848b4e80d2333575968
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Rett Syndrome (RTT) is a rare and progressive neurodevelopmental disorder that is caused by de novo mutations in the X-linked Methyl CpG binding protein 2 (MECP2) gene and is subjected to X-chromosome inactivation. RTT is commonly associated with neu
Externí odkaz:
https://doaj.org/article/206a236184654a22828c914682f0aecf
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1253 (2021)
Methyl CpG binding protein 2 (MeCP2) is the main DNA methyl-binding protein in the brain that binds to 5-methylcytosine and 5-hydroxymethyl cytosine. MECP2 gene mutations are the main origin of Rett Syndrome (RTT), a neurodevelopmental disorder in yo
Externí odkaz:
https://doaj.org/article/0935ed09a4fd4a22a99269c9820f4756
Autor:
Shervin Pejhan, Mojgan Rastegar
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 75 (2021)
Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with patients displaying neurological regression and autism spectrum features. The affected individuals are primarily young females, and more than 95% of patients carry de
Externí odkaz:
https://doaj.org/article/6a8e16a883d0464d85f635bf342ad92f
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1845 (2019)
Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT), MECP2 duplication
Externí odkaz:
https://doaj.org/article/d7f136ad28c64ac9b4d1fd967bf2d291
Akademický článek
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