Zobrazeno 1 - 10
of 2 172
pro vyhledávání: '"Mdr1 gene"'
Autor:
Olugbenga Ayodeji Mokuolu, George Oche Ambrose, Mohammed Baba Abdulkadir, Selimat Ibrahim, Itiolu Ibilola Funsho, Toluwani Mokuolu
Publikováno v:
Current Research in Microbial Sciences, Vol 7, Iss , Pp 100304- (2024)
Summary: Background: The genetic progression of the MDR1 gene in Plasmodium falciparum, a key factor in drug resistance, presents significant challenges for malaria control. This study aims to elucidate the genetic diversity and evolutionary dynamics
Externí odkaz:
https://doaj.org/article/345a7b12a7dd4d1d8efe9b492ff5ddbd
Autor:
Maede Parishan, Mahmoud Nateghi
Publikováno v:
یافتههای نوین در علوم زیستی, Vol 9, Iss 4, Pp 257-266 (2023)
This study aimed to identify PGP and MRPA genes in clinical isolates of Leishmania. The genes of pgpa (MRPA) and mdr1 (PGP) are involved in the drug resistance, their products act as dependent transporters of ATP (ABC Transporter) in the reflux of dr
Externí odkaz:
https://doaj.org/article/4971666668764a7087542d336a95c512
Autor:
Bahareh Samii, Abbas Jafarian, Mohamad Rabbani, Behzad Zolfaghari, Soheila Rahgozar, Elnaz Pouraboutaleb
Publikováno v:
Research in Pharmaceutical Sciences, Vol 18, Iss 4, Pp 381-391 (2023)
Background and purpose: One strategy to overcome methotrexate (MTX) resistance in acute lymphoblastic leukemia is suppressing MDR1 expression. It has been proved Astragalus polysaccharides (APS) exert their anticancer effect by reversing drug resista
Externí odkaz:
https://doaj.org/article/1fd5d535001046ceba6835271773594e
Autor:
Ivan V. Chernikov, Ul’yana A. Ponomareva, Mariya I. Meschaninova, Irina K. Bachkova, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Molecules, Vol 29, Iss 4, p 786 (2024)
Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectiv
Externí odkaz:
https://doaj.org/article/a9812619882e4165812a0c26a5a07816
Akademický článek
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Autor:
Aleksandra T. Diakonova, Nadezhda I. Pavlova, Vladislav A. Alekseev, Lyubov S. Mironova, Khariton A. Kurtanov, Vladimir V. Dodokhov, Innokenty D. Ushnitsky
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss 4, Pp 576-580 (2021)
The aim of our study was to investigate the relationship between the MDR1 and MTHFR gene polymorphisms and non-syndromic cleft lip with or without cleft palate (NSCL/P) in the Yakut population in the Republic of Sakha (Yakutia). Methods and Results:
Externí odkaz:
https://doaj.org/article/c306a2ec034a472fbd003ce7154fc1da
Autor:
Krupa A. Patel, Masumi H. Bhatt, Rajvi V. Hirani, Vidheesha A. Patel, Vishvas N. Patel, Gaurang B. Shah, Mehul R. Chorawala
Publikováno v:
Heliyon, Vol 8, Iss 11, Pp e11278- (2022)
Background: Selecting a medicine has a significant impact on the quality of therapy including efficacy and safety. P-glycoprotein and CYP3A4 share several common substrates known as bi-substrates. Both play major role in the pharmacokinetics and phar
Externí odkaz:
https://doaj.org/article/bbf8caf89927430899076c852a47ca27
Publikováno v:
Journal of Research in Applied and Basic Medical Sciences, Vol 7, Iss 1, Pp 1-10 (2021)
Background & Aims: In recent years, the emergence of multidrug resistance in gastric cancer has been a major challenge in treatment of gastric cancer. To deal with the problem, studies and researches were conducted on Sclareol and have turned up the
Externí odkaz:
https://doaj.org/article/a3923a5681544275bd832bbcee2293ef
Publikováno v:
International Journal of General Medicine, Vol Volume 14, Pp 665-671 (2021)
Fang Chen,1 Jing Zhang,2 Cheng-Xue Bian,2 Jian Zhang,3 Xiang-Bin Xin,2 Yang-Yang Pan,2 Xuan Zhang2 1Department of Cardiology, Yinchuan First People’s Hospital, Yinchuan, People’s Republic of China; 2Department of Cardiology, Ningxia Medical Unive
Externí odkaz:
https://doaj.org/article/9028eeb571434a59bfa7144d3bf8481a
Autor:
N. M. Popova, A. V. Shchulkin, I. V. Chernykh, A. S. Esenina, M. M. Gradinar, E. N. Yakusheva
Publikováno v:
Акушерство, гинекология и репродукция, Vol 13, Iss 2, Pp 164-173 (2019)
This review addresses the function of the protein-transporter glycoprotein-P (Pgp, ABCB1 protein) and the expression of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals. We discuss the relationship between the trans
Externí odkaz:
https://doaj.org/article/02cc39edd35943f8ba648e22c5958e5e