Zobrazeno 1 - 10
of 17 161
pro vyhledávání: '"Mdm2"'
Autor:
Theresia Indah Budhy, Ira Arundina, Anis Irmawati, Sidarningsih, Meircurius Dwi Condro Surboyo, Cecillia Octavianni Raharjo, Ciptantyo Septyan Akbar, Malika Qadira Rahmalia
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 12, Iss 4, Pp 748-758 (2024)
Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioac
Externí odkaz:
https://doaj.org/article/82db1a0c3f874516a3afbf761a2dd277
Autor:
Jiajia Wang, Hui Liu, Zeyuan Yu, Qianqian Zhou, Feifei Sun, Jingying Han, Lin Gao, Baokai Dou, Hanwen Zhang, Jiawei Fu, Wenqiao Jia, Weiwen Chen, Jing Hu, Bo Han
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activation to search for pot
Externí odkaz:
https://doaj.org/article/53f2bb0e165443118786ddd413f4b43e
Autor:
Xiaoxia Xu, Hongbin Qiu
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Gouty arthritis (GA) is characterized by monosodium urate (MSU) crystal accumulation that instigates NLRP3-mediated pyroptosis; however, the underlying regulatory mechanisms have yet to be fully elucidated. The present research en
Externí odkaz:
https://doaj.org/article/57da4f78c4c24d2da0386df79be489fd
Autor:
Ann-Katharina Becker, Behrus Puladi, Kunpeng Xie, Angela Cassataro, Rebekka Götzl, Frank Hölzle, Justus P. Beier, Ruth Knüchel-Clarke, Till Braunschweig
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Background Liposarcomas are among the most common mesenchymal malignancies. However, the therapeutic options are still very limited and so far, targeted therapies had not yet been established. Immunotherapy, which has been a breakthrough in
Externí odkaz:
https://doaj.org/article/c2107f0aff2548f4abc4d7f7832de02c
Autor:
Joanna E. Zawacka
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) originate from preleukemic hematopoietic conditions, such as clonal hematopoiesis of indeterminate potential (CHIP) or clonal cytopenia of undetermined significance (CCUS) and h
Externí odkaz:
https://doaj.org/article/2827b0a3c4664871b84708b23e6e72c3
Autor:
Itaru Ogawa, Michiyuki Hakozaki, Yoichi Kaneuchi, Takeo Suzuki, Takuya Nikaido, Shoki Yamada, Akihito Utsumi, Osamu Hasegawa, Hideki Sano, Yoshihiro Matsumoto
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Atypical lipomatous tumors (ALTs) are locally aggressive adipocytic malignancies that frequently occur in middle-aged adults. We report the rare case of an ALT of the thigh that occurred in a 4-year-old girl. Since the tumor was initially diagnosed a
Externí odkaz:
https://doaj.org/article/576095008e304cab89ccfaf717b08333
Autor:
Sarfaraj Niazi, C. P. Kavana, H. K. Aishwarya, Chandan Dharmashekar, Anisha Jain, Tanveer A. Wani, Chandan Shivamallu, Madhusudan N. Purohit, Shiva Prasad Kollur
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Introduction: Leukemia is a global health concern that requires alternative treatments due to the limitations of the FDA-approved drugs. Our focus is on p53, a crucial tumor suppressor that regulates cell division. It appears possible to stabilize p5
Externí odkaz:
https://doaj.org/article/c2f25805b5ad445c8b6aa5f65cb2137a
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Staple peptides, which have a significantly enhanced pharmacological profile, are promising therapeutic molecules due to their remarkable resistance to proteolysis and cell-penetrating properties. In this study, we designed and synthesized a series o
Externí odkaz:
https://doaj.org/article/4d138353066445c7885397d1867103e7
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Apatinib was the first anti-angiogenic agent approved for treatment of metastatic gastric cancer (GC). However, the emergence of resistance was inevitable. Thus investigating new and valuable off-target effect of apatinib directly against ca
Externí odkaz:
https://doaj.org/article/569eb4a3138c4e2886b059fcf7ef856f
Publikováno v:
Endocrine Oncology, Vol 4, Iss 1, Pp 1-9 (2024)
Androgen receptor (AR) and its constitutively active splice variant, AR Variant 7 (AR-V7), regulate genes essential for the development and progression of prostate cancer. Degradation of AR and AR-V7 by the ubiquitination proteasomal pathway is impor
Externí odkaz:
https://doaj.org/article/934fbf2eb6f847de87e66036da409044