Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Md. Ruhul Abid"'
For decades, elevated levels of reactive oxygen species (ROS) have been associated with the pathogenesis of cardiovascular diseases (CVD), including myocardial ischemia and infarction (MI). However, several large clinical trials failed to demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7150549f5a0fbc22afb5f6e29a816ba
https://doi.org/10.5772/intechopen.93568
https://doi.org/10.5772/intechopen.93568
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28454 (2011)
BACKGROUND: ADPH oxidase-derived reactive oxygen species (ROS) play important roles in redox homeostasis and signal transduction in endothelial cells (ECs). We previously demonstrated that c-Src plays a key role in VEGF-induced, ROS-dependent selecti
Externí odkaz:
https://doaj.org/article/9608cf14e7fc45b6af768f01bdde7bed
Autor:
Frank W. Sellke, Maan A. Awad, May Z. Gao, Isabella G. McCormack, Sarah R. Aldosari, Md. Ruhul Abid
Publikováno v:
Modulation of Oxidative Stress in Heart Disease ISBN: 9789811389450
Depending on their levels, source of generation, and subcellular locations, reactive oxygen species (ROS) are known to have paradoxical effects on coronary vascular endothelium. At low concentrations, ROS contribute to physiological signaling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40d50ab45e6d7a068efe43cc5a371b6
https://doi.org/10.1007/978-981-13-8946-7_2
https://doi.org/10.1007/978-981-13-8946-7_2
Autor:
Richard T. Clements, Jun Feng, Abdulmounem Yassin-Kassab, Yuhong Liu, Arthur Lyra, Md. Ruhul Abid, Arthus V.D. Zanetti, Frank W. Sellke, Ehtesham Shafique, Brenda Cordeiro, Wing C. Choy, Cesario Bianchi, Mohammed Arafah, Laura E. Benjamin
Publikováno v:
Aging (Albany NY)
Age-associated decline in cardiovascular function is believed to occur from the deleterious effects of reactive oxygen species (ROS). However, failure of recent clinical trials using antioxidants in patients with cardiovascular disease, and the recen
Endothelium-Dependent Coronary Vasodilatation Requires NADPH Oxidase-Derived Reactive Oxygen Species
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1703-1710
Objective— To determine the functional significance of physiological reactive oxygen species (ROS) levels in endothelium-dependent nitric oxide (NO)-mediated coronary vasodilatation. Methods and Results— Endothelium-derived NO is important in reg
Publikováno v:
FEBS Letters. 584:3131-3136
The aim of the present study is to determine the role of intracellular Ca(2+) in VEGF signaling. We demonstrate that reduction in Ca(2+) by chelating compound BAPTA-AM or by IP(3)-endoplasmic reticulum blocker 2-APB selectively inhibited VEGF-induced
Autor:
Robert J. Nadeau, Md. Ruhul Abid, Shou-Ching Shih, Dan Li, William C. Aird, Takashi Minami, Katherine Spokes
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:2042-2048
Objective— Recently, we reported that the forkhead transcription factor, FKHR/FOXO1, is required for vascular endothelial growth factor (VEGF)–mediated upregulation of a number of genes in endothelial cells. Here, we tested the hypothesis that he
Publikováno v:
Journal of Thrombosis and Haemostasis. 6:1804-1811
Summary. Background: Growth Arrest Specific gene product 6 (gas6) is a γ-carboxylated protein that protects endothelial cells against apoptosis. Gas6 has previously been shown to induce phospatidyl-3-inositol-kinase (PI3K)/Akt signaling. Other studi
Publikováno v:
Endothelium. 15:143-148
Thrombomodulin (TM) is a cell surface anticoagulant glycoprotein that plays a key role in the protein C pathway. TM expression in endothelial cells may be modulated by a variety of extracellular signals. Most notably, TM has been shown to be downregu
Publikováno v:
Microvascular Research. 72:136-145
Endothelial cell phenotypes are differentially regulated between different sites of the vascular tree. We tested the hypothesis that endocan, a novel soluble dermatan sulfate proteoglycan, is differentially expressed in the intact endothelium and tha