Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Md. Hasan Zaki"'
Autor:
Monira Obaid, S. M. Nashir Udden, Paromita Deb, Nadine Shihabeddin, Md. Hasan Zaki, Subhrangsu S. Mandal
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Abstract Long noncoding RNAs (lncRNAs) are emerging as major regulators of a variety of cell signaling processes. Many lncRNAs are expressed in immune cells and appear to play critical roles in the regulation of immune response. Here, we have investi
Externí odkaz:
https://doaj.org/article/1f55d91dc3db457aaef4b4a662414db3
Autor:
S.M. Nashir Udden, Lan Peng, Jia-Liang Gan, John M. Shelton, James S. Malter, Lora V. Hooper, Md. Hasan Zaki
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2756-2770 (2017)
Although NOD2 is the major inflammatory bowel disease susceptibility gene, its role in colorectal tumorigenesis is poorly defined. Here, we show that Nod2-deficient mice are highly susceptible to experimental colorectal tumorigenesis independent of g
Externí odkaz:
https://doaj.org/article/2a0242f5b57a47efa3685b3a755f56d5
Autor:
Shuiqing Hu, Lan Peng, Youn-Tae Kwak, Erin McElvania Tekippe, Chandrashekhar Pasare, James S. Malter, Lora V. Hooper, Md. Hasan Zaki
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1922-1936 (2015)
Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown. Here, we show that Aim2−
Externí odkaz:
https://doaj.org/article/4c4c2b4558de4420bff005aaf3b1f0da
Autor:
John M. Shelton, Md. Hasan Zaki, Jia-Liang Gan, Lan Peng, S. M. Nashir Udden, James S. Malter, Lora V. Hooper
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2756-2770 (2017)
Summary Although NOD2 is the major inflammatory bowel disease susceptibility gene, its role in colorectal tumorigenesis is poorly defined. Here, we show that Nod2-deficient mice are highly susceptible to experimental colorectal tumorigenesis independ
Publikováno v:
International review of cell and molecular biology. 344
Innate immunity employs germline-encoded pattern recognition receptors (PRRs) to sense microbial pattern molecules. Recognition of pathogen-associated molecular patterns (PAMPs) by various PPRs located on the cell membrane or in the cytosol leads to
Autor:
Tarsha L. Harris, Md. Hasan Zaki, Benjamin A. Edwards, Thirumala-Devi Kanneganti, Jack D. Bui, Helen Floersh, Maureen A. McGargill, John R. Lukens, Peter Vogel
Publikováno v:
International Immunology. 27:161-166
Drak2 is a promising therapeutic target to treat organ-specific autoimmune diseases such as type 1 diabetes and multiple sclerosis without causing generalized immune suppression. Inhibition of Drak2 may also prevent graft rejection following organ tr
Autor:
Wanyin Deng, B. Brett Finlay, Mohamed Lamkanfi, Md. Hasan Zaki, Peter Vogel, Zhiping Liu, Prajwal Gurung, Thirumala-Devi Kanneganti
Publikováno v:
Journal of Biological Chemistry. 287:16955-16964
Citrobacter rodentium is an enteric bacterial pathogen of the mouse intestinal tract that triggers inflammatory responses resembling those of humans infected with enteropathogenic and enterohemorrhagic Escherichia coli. Inflammasome signaling is emer
Autor:
James S. Malter, Lora V. Hooper, Shuiqing Hu, Md. Hasan Zaki, Youn-Tae Kwak, Chandrashekhar Pasare, Erin McElvania TeKippe, Lan Peng
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1922-1936 (2015)
Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown. Here, we show that Aim2(-/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b0a4053f4c402f882603a35b32cbc3
https://europepmc.org/articles/PMC5477202/
https://europepmc.org/articles/PMC5477202/
Publikováno v:
Drug Discovery Today: Disease Mechanisms. 8:e71-e78
Colorectal cancer is a major health problem in developed countries. Chronic intestinal inflammation predisposes individuals to the development of colorectal cancer. The intracellular NOD-like receptors (NLRs) have emerged as crucial regulators of int
Publikováno v:
Trends in Immunology. 32:171-179
Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis constitute a major health problem in developed countries. Moreover, IBD predisposes to the development of colorectal cancer. The intracellular NOD-like receptor Nlrp3 is