Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Md. Abul Hassan Samee"'
Autor:
Mashrur Ahmed Yafi, Md. Hasibul Husain Hisham, Francisco Grisanti, James F. Martin, Atif Rahman, Md. Abul Hassan Samee
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract A critical challenge of single-cell spatial transcriptomics (sc-ST) technologies is their panel size. Being based on fluorescence in situ hybridization, they are typically limited to panels of about a thousand genes. This constrains research
Externí odkaz:
https://doaj.org/article/5a6db1aa711c4b0fa1cb3075008b7125
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105945- (2023)
Summary: The bendability of genomic DNA impacts chromatin packaging and protein-DNA binding. However, we do not have a comprehensive understanding of the motifs influencing DNA bendability. Recent high-throughput technologies such as Loop-Seq offer a
Externí odkaz:
https://doaj.org/article/d4631a7ad36a447f95870a21a63c7b18
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Sequence-specific transcription factors (TFs) recognize motifs of related nucleotide sequences at their DNA binding sites. Upon binding at these sites, TFs regulate critical molecular processes such as gene expression. It is widely assumed t
Externí odkaz:
https://doaj.org/article/1514fc4ba0f14af19e1012d0b3401bfe
Autor:
Jeffrey D. Steimle, Francisco J. Grisanti Canozo, Minjun Park, Zachary A. Kadow, Md. Abul Hassan Samee, James F. Martin
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia and a major risk factor for stroke, often arises through ectopic electrical impulses derived from the pulmonary veins (PVs). Sequence variants in enhancers controlling expression
Externí odkaz:
https://doaj.org/article/f2e57560ce0e4f0dadfc2264dfb012c0
Autor:
S. A. Amali S. Subasinghe, Robia G. Pautler, Md. Abul Hassan Samee, Jason T. Yustein, Matthew J. Allen
Publikováno v:
Biosensors, Vol 12, Iss 7, p 478 (2022)
Hypoxia in solid tumors is associated with poor prognosis, increased aggressiveness, and strong resistance to therapeutics, making accurate monitoring of hypoxia important. Several imaging modalities have been used to study hypoxia, but each modality
Externí odkaz:
https://doaj.org/article/970438b413ce4edeafe17fe702187c1f
Autor:
Md. Abul Hassan Samee, Tara Lydiard-Martin, Kelly M. Biette, Ben J. Vincent, Meghan D. Bragdon, Kelly B. Eckenrode, Zeba Wunderlich, Javier Estrada, Saurabh Sinha, Angela H. DePace
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 236-245 (2017)
Computational models of enhancer function generally assume that transcription factors (TFs) exert their regulatory effects independently, modeling an enhancer as a “bag of sites.” These models fail on endogenous loci that harbor multiple enhancer
Externí odkaz:
https://doaj.org/article/9483d46b30264d13827a992033d7aa7d
Autor:
Weiyi Xu, Andrea Graves, Monika Weisz-Hubshman, Lamees Hegazy, Christina Magyar, Zian Liu, Eleni Nasiotis, Md Abul Hassan Samee, Thomas Burris, Seema Lalani, Lilei Zhang
Publikováno v:
Human Molecular Genetics. 32:959-970
Haploinsufficiency of TGF-beta-activated kinase 1 (MAP3K7) binding protein 2 (TAB2) has been associated with congenital heart disease and more recently multiorgan structural abnormalities. Missense variant represents a major proportion of non-synonym
Autor:
Md Mamunur Rashid, Brooke A. Corbin, Pavan Jella, Caitlyn J. Ortiz, Md. Abul Hassan Samee, Robia G. Pautler, Matthew J. Allen
Publikováno v:
Journal of the American Chemical Society. 144(50)
Hypoxia is a hallmark of many diseases, including cancer, arthritis, heart and kidney diseases, and diabetes, and it is often associated with disease aggressiveness and poor prognosis. Consequently, there is a critical need for imaging hypoxia in a n
Autor:
Mashrur Ahmed Yafi, Md. Hasibul Husain Hisham, Francisco Grisanti, Atif Rahman, Md. Abul Hassan Samee
A fundamental limitation of the emerging single-cell spatial transcriptomics (sc-ST) technologies is their panel size. Being based on fluorescence in situ hybridization, an sc-ST dataset can profile only a pre-determined panel of a few hundred genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42c30bd09f0982e16b6194d2e45dc8a6
https://doi.org/10.1101/2022.09.25.509418
https://doi.org/10.1101/2022.09.25.509418
Spatial transcriptomics (ST) holds the promise to identify the existence and extent of spatial variation of gene expression in complex tissues. Such analyses could help identify gene expression signatures that distinguish between healthy and disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3aa1bda9f6489968d3562e0cfd83601
https://doi.org/10.1101/2022.09.25.509381
https://doi.org/10.1101/2022.09.25.509381