Výsledky vyhledávání - "Md Mahiuddin Ahmed"

Akademický článek

Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.

Autor: Md Mahiuddin Ahmed, A Ranjitha Dhanasekaran, Aaron Block, Suhong Tong, Alberto C S Costa, Melissa Stasko, Katheleen J Gardiner

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119491 (2015)

Down syndrome (DS) is caused by an extra copy of human chromosome 21 (Hsa21). Although it is the most common genetic cause of intellectual disability (ID), there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic fo

Externí odkaz: https://doaj.org/article/0eeba684cf8246b9877a83419fa003e6

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Akademický článek

Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction

Autor: Esteban M. Lucero, Ronald K. Freund, Alexandra Smith, Noah R. Johnson, Breanna Dooling, Emily Sullivan, Olga Prikhodko, Md. Mahiuddin Ahmed, David A. Bennett, Timothy J. Hohman, Mark L. Dell’Acqua, Heidi J. Chial, Huntington Potter

Publikováno v: iScience, Vol 25, Iss 11, Pp 105288- (2022)

Summary: Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. T

Externí odkaz: https://doaj.org/article/b454f82fd1d14209a2333f435a60d98d

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Akademický článek

Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?

Autor: Md. Mahiuddin Ahmed, Noah R. Johnson, Timothy D. Boyd, Christina Coughlan, Heidi J. Chial, Huntington Potter

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)

Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging. In addition to serving as

Externí odkaz: https://doaj.org/article/52ccc50c35594f67b486d1714318141b

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Akademický článek

Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy

Autor: Md. Mahiuddin Ahmed, Andrew J. Carrel, Yasmin Cruz Del Angel, Jessica Carlsen, Ajay X. Thomas, Marco I. González, Katheleen J. Gardiner, Amy Brooks-Kayal

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Epilepsy is characterized by recurrent, spontaneous seizures and is a major contributor to the global burden of neurological disease. Although epilepsy can result from a variety of brain insults, in many cases the cause is unknown and, in a significa

Externí odkaz: https://doaj.org/article/2dd34466bf12465bb4794d3c67504428

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Increased

Autor: Esteban M, Lucero, Ronald K, Freund, Alexandra, Smith, Noah R, Johnson, Breanna, Dooling, Emily, Sullivan, Olga, Prikhodko, Md Mahiuddin, Ahmed, David A, Bennett, Timothy J, Hohman, Mark L, Dell'Acqua, Heidi J, Chial, Huntington, Potter

Publikováno v: iScience. 25(11)

Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. These bioc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d80b14e29943670e97da57f1aea92f22
https://pubmed.ncbi.nlm.nih.gov/36304124

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Kif11 overexpression rescues cognition, long-term potentiation, and spine defects in mouse and cell models of Alzheimer’s disease

Autor: Emily Sullivan, Huntington Potter, Olga Prikhodko, Md. Mahiuddin Ahmed, Noah R. Johnson, Heidi J. Chial, Mark L. Dell'Acqua, Esteban M. Lucero, Breanna Dooling, Ronald K. Freund

Competitive inhibition of kinesin motor proteins by amyloid-beta (Aβ) may contribute to alterations in the neuronal microtubule cytoskeleton that can disrupt plasticity mechanisms required for learning and memory, such as long-term potentiation (LTP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88d7b1572b71a752d572749f6c14b90b
https://doi.org/10.1101/2021.09.09.459627

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