Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Md Mahiuddin, Ahmed"'
1
Akademický článek
Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction
Autor: Esteban M. Lucero, Ronald K. Freund, Alexandra Smith, Noah R. Johnson, Breanna Dooling, Emily Sullivan, Olga Prikhodko, Md. Mahiuddin Ahmed, David A. Bennett, Timothy J. Hohman, Mark L. Dell’Acqua, Heidi J. Chial, Huntington Potter
Publikováno v: iScience, Vol 25, Iss 11, Pp 105288- (2022)
Summary: Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. T
Externí odkaz: https://doaj.org/article/b454f82fd1d14209a2333f435a60d98d
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2
Akademický článek
The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice
Autor: Md. Mahiuddin Ahmed, Athena Ching-Jung Wang, Mihret Elos, Heidi J. Chial, Stefan Sillau, D. Adriana Solano, Christina Coughlan, Leila Aghili, Paige Anton, Neil Markham, Vanesa Adame, Katheleen J. Gardiner, Timothy D. Boyd, Huntington Potter
Publikováno v: Neurobiology of Disease, Vol 168, Iss , Pp 105694- (2022)
Down syndrome (DS) is characterized by chronic neuroinflammation, peripheral inflammation, astrogliosis, imbalanced excitatory/inhibitory neuronal function, and cognitive deficits in both humans and mouse models. Suppression of inflammation has been
Externí odkaz: https://doaj.org/article/afca7c18fdef4a53a47db47b60243c02
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3
Akademický článek
Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?
Autor: Md. Mahiuddin Ahmed, Noah R. Johnson, Timothy D. Boyd, Christina Coughlan, Heidi J. Chial, Huntington Potter
Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)
Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging. In addition to serving as
Externí odkaz: https://doaj.org/article/52ccc50c35594f67b486d1714318141b
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4
Akademický článek
Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy
Autor: Md. Mahiuddin Ahmed, Andrew J. Carrel, Yasmin Cruz Del Angel, Jessica Carlsen, Ajay X. Thomas, Marco I. González, Katheleen J. Gardiner, Amy Brooks-Kayal
Publikováno v: Frontiers in Neurology, Vol 12 (2021)
Epilepsy is characterized by recurrent, spontaneous seizures and is a major contributor to the global burden of neurological disease. Although epilepsy can result from a variety of brain insults, in many cases the cause is unknown and, in a significa
Externí odkaz: https://doaj.org/article/2dd34466bf12465bb4794d3c67504428
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7
Increased
Autor: Esteban M, Lucero, Ronald K, Freund, Alexandra, Smith, Noah R, Johnson, Breanna, Dooling, Emily, Sullivan, Olga, Prikhodko, Md Mahiuddin, Ahmed, David A, Bennett, Timothy J, Hohman, Mark L, Dell'Acqua, Heidi J, Chial, Huntington, Potter
Publikováno v: iScience. 25(11)
Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. These bioc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d80b14e29943670e97da57f1aea92f22
https://pubmed.ncbi.nlm.nih.gov/36304124
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10
Akademický článek
Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.
Autor: Md Mahiuddin Ahmed, A Ranjitha Dhanasekaran, Aaron Block, Suhong Tong, Alberto C S Costa, Melissa Stasko, Katheleen J Gardiner
Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119491 (2015)
Down syndrome (DS) is caused by an extra copy of human chromosome 21 (Hsa21). Although it is the most common genetic cause of intellectual disability (ID), there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic fo
Externí odkaz: https://doaj.org/article/0eeba684cf8246b9877a83419fa003e6
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