Výsledky vyhledávání - "Md, Waterfield"

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

Autor: Salim K, Mj, Bottomley, Querfurth E, Marketa Zvelebil, Gout I, Scaife R, Rl, Margolis, Gigg R, Ci, Smith, Pc, Driscoll, Md, Waterfield, Panayotou G

Publikováno v: Europe PubMed Central

Pleckstrin homology (PH) domains may act as membrane localization modules through specific interactions with phosphoinositide phospholipids. These interactions could represent responses to second messengers, with scope for regulation by soluble inosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2559fbeede1e6403e8bfe1fdf9b3f43d
https://pubmed.ncbi.nlm.nih.gov/8947047

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A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC

Autor: Eng C, Dp, Smith, Lm, Mulligan, Cs, Healey, Marketa Zvelebil, Tj, Stonehouse, Ma, Ponder, Ce, Jackson, Md, Waterfield, Ba, Ponder

Publikováno v: Europe PubMed Central

Germline mutations within one of six codons of the RET proto-oncogene account for the majority of cases of multiple endocrine neoplasia (MEN) type 2A and type 2B and familial medullary thyroid carcinoma (FMTC). MEN 2A and FMTC mutations characterised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7af82beae53881b5f478a2310eb8ee23
https://pubmed.ncbi.nlm.nih.gov/7845675

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The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Autor: Pelicci G, Giordano S, Zhen Z, Ae, Salcini, Lanfrancone L, Alberto BARDELLI, Panayotou G, Md, Waterfield, Ponzetto C, Pg, Pelicci

Publikováno v: University of Copenhagen
Europe PubMed Central

The receptor of Hepatocyte Growth Factor-Scatter Factor (HGF) is a tyrosine kinase which regulates cell motility and growth. After ligand-induced tyrosine phosphorylation, the HGF receptor associates with the Shc adaptor, via the SH2 domain. Site-dir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8b5ff8f63c9890a5073f3abe38c29f8c
http://hdl.handle.net/2318/43169

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Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain

Autor: TC He, H Zhuang, N Jiang, MD Waterfield, DM Wojchowski

Publikováno v: Blood. 82(12)

Using an active, HAI epitope-tagged form of the murine erythropoietin (EPO) receptor and via direct coimmunoprecipitation, the p85 regulatory subunit of phosphatidyl inositol-3 kinase (p85/PI3-K) is shown to associate with the EPO receptor in transfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7aba6c6bee8badaa6f459cf543460c
https://pubmed.ncbi.nlm.nih.gov/7505116

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Akademický článek

Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis.

Autor: Wang, Na¹ (AUTHOR), Liu, Lushan¹ (AUTHOR), He, Wei¹ (AUTHOR), Shang, Na¹ (AUTHOR), Li, Junyu¹ (AUTHOR), Qin, Zhou¹ (AUTHOR), Du, Xiaoxia² (AUTHOR) 364906784@qq.com

Publikováno v: BMC Infectious Diseases. 5/8/2023, Vol. 23 Issue 1, p1-12. 12p.

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Structural and functional features of a cell surface phosphoglycoprotein associated with tumorigenic phenotype in human fibroblast x HeLa cell hybrids

Autor: Dr, Sutherland, Dc, Bicknell, Julian Downward, Parker P, Md, Waterfield, Ma, Baker, Mf, Greaves, Ej, Stanbridge

Publikováno v: Europe PubMed Central

Monoclonal antibodies have been raised against a dimeric cell surface antigen (p75/150) which is specifically associated with the tumorigenic phenotype in human fibroblast X HeLa hybrids. During biosynthesis, a precursor molecule (p70/140), was assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fcf37284b83bad055fbc1b1a63472e67
https://pubmed.ncbi.nlm.nih.gov/3080434

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Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains

Autor: Alberto BARDELLI, Maina F, Gout I, Mj, Fry, Md, Waterfield, Pm, Comoglio, Ponzetto C

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a polypeptide which induces motility and/or mitogenesis in epithelial cells. The receptor for HGF/SF, p190MET, is a two-chain transmembrane tyrosine kinase encoded by the MET proto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a32bb665c550786d4cc8c729378f8565
http://www.scopus.com/inward/record.url?eid=2-s2.0-0026644455&partnerID=MN8TOARS

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The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth

Autor: Sj, Leevers, David Weinkove, Lk, Macdougall, Hafen E, Md, Waterfield

Publikováno v: Europe PubMed Central

Phosphoinositide 3-kinases (PI3Ks) have been identified in an evolutionarily diverse range of organisms, including mammals, Drosophila, yeast, plants and Dictyostelium. They are activated by a multitude of extracellular signals and implicated in mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02ed0ce493c34c7fd4c56f6e2d1e8382
http://europepmc.org/abstract/med/8978685

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Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity

Autor: Julian Downward, Md, Waterfield, Pj, Parker

Publikováno v: Europe PubMed Central

The effect of autophosphorylation and protein kinase C-catalyzed phosphorylation on the tyrosine-protein kinase activity and ligand binding affinity of the epidermal growth factor (EGF) receptor has been studied. Kinetic parameters for the phosphoryl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::60020f902df758a0710dbe33990b8034
http://europepmc.org/abstract/med/2997213

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