Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

Autor: Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.

Publikováno v: In Cell 24 September 2015 163(1):160-173

PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state

Autor: Mair, Iris, Besusso, Dario, Saul, Louise, Patel, Sarju D, Ravindran, Rahul, McPherson, Rhoanne C, Leech, Melanie D, O'Connor, Richard A, Anderton, Stephen M, Mellanby, Richard J

Publikováno v: Mair, I, Besusso, D, Saul, L, Patel, S D, Ravindran, R, McPherson, R C, Leech, M D, O'Connor, R A, Anderton, S M & Mellanby, R J 2019, ' PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state ', European Journal of Immunology, vol. 49, no. 1, pp. 112-120 . https://doi.org/10.1002/eji.201847868

T cell adaptation is an important peripheral tolerogenic process which ensures that the T cell population can respond effectively to pathogens but remains tolerant to self-antigens. We probed the mechanisms of T cell adaptation using an experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::65a29494fc4458f435ed257809e220d1
https://hdl.handle.net/20.500.11820/2f4a1c10-b517-47f3-877b-d9bb7b317f86

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Autor: Colbeck, Emily J, Hindley, James P, Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C, Turner, Darryl G, Ladell, Kristin, Price, David A, O'Connor, Richard A, Anderton, Stephen M, Godkin, Andrew J, Gallimore, Awen M

Publikováno v: Colbeck, E J, Hindley, J P, Smart, K, Jones, E, Bloom, A, Bridgeman, H, McPherson, R C, Turner, D G, Ladell, K, Price, D A, O'Connor, R A, Anderton, S M, Godkin, A J & Gallimore, A M 2015, ' Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors ', Oncotarget, vol. 6, no. 28, pp. 24649-59 . https://doi.org/10.18632/oncotarget.5584

Foxp3+ regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6610019ae46174a00831709867bcd476

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