Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mcmillan Lynette Jane"'
Autor:
Mcmillan Lynette Jane, David J. Behm, Jian Jin, Kalindi Vaidya, Zining Wu, Michael J. Neeb, Dongchuan Shi, Karl F. Erhard, Feng Wang, Brian F. Guida, Sarah K. Lawrence, Christopher P. Evans, Stephen A. Douglas, Yonghui Wang, Ralph A. Rivero, Jyoti Disa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2860-2864
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-sp
Autor:
Brandon J. Turunen, William J. Zuercher, Elizabeth A. Davenport, Mcmillan Lynette Jane, Robert S. Ames, Lorena A. Kallal, Maggie Truong, Keith R. Hornberger, M. Will, Wensheng Xie, Weilin Tiger Bee, Hu Li
Publikováno v:
Journal of biomolecular screening. 17(7)
In this study, the development of an image-based high-content screening (HCS) binding assay for the seven-transmembrane (7TM) receptor Smoothened (Smo) is described. Using BacMam-based gene delivery of Smo, BODIPY-cyclopamine as a fluorescent probe,
Autor:
Mcmillan Lynette Jane, William J. Zuercher, Cynthia M. Rominger, Peter J. Tummino, Quinn Lu, Zhihong Lai, Brandon J. Turunen, David H. Rominger, Aidan G. Gilmartin, Lorena A. Kallal, Elizabeth A. Davenport, Keith R. Hornberger, Richard R. Gontarek, M. Will, Weilin Tiger Bee, Kenneth W. M. Lawrie, Maggie Truong, Robert A. Copeland
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 329(3)
The Smoothened receptor (Smo) mediates hedgehog (Hh) signaling critical for development, cell growth, and migration, as well as stem cell maintenance. Aberrant Hh signaling pathway activation has been implicated in a variety of cancers, and small-mol
Autor:
Mcmillan Lynette Jane, James J. Foley, Paul R. Murdock, Philip G. Szekeres, Shelagh Wilson, Andrew J. Murphy, Sajda Naheed, Claire Scott, George P. Livi, Jon K. Chambers, Derk J. Bergsma, Emir Duzic, Katie Freeman, John J. Trill, Henry M. Sarau, Christine Klein, Paul H. Taylor, Macdonald Lynn, Nambi Aiyar, Ann M. Swift, Robert S. Ames, Jeanette M. Watson, Yuan Zhu, Guillaume Hervieu, Lisa Vawter, Megan M. McLaughlin
Publikováno v:
The Journal of biological chemistry. 275(15)
Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is less well known that UDP-glucose may possess pharmacological activity, suggesting that a rec
Autor:
Nabil Elshourbagy, Jeffrey L. Mooney, Mcmillan Lynette Jane, Hsiao-Ling Wu, Sharon Butler, Angela M. Smith, Laura R. Fitzgerald, Shelagh Wilson, Philip G. Szekeres, Derk J. Bergsma, Jane Miller, Gillian I. Rennie, Alison I. Muir, Lisa D. Spinage, Stephanie E. Guerrera, Jon K. Chambers, Lisa Vawter, Paul R. Murdock
Publikováno v:
The Journal of biological chemistry. 275(27)
Neuromedins are a family of peptides best known for their contractile activity on smooth muscle preparations. The biological mechanism of action of neuromedin U remains unknown, despite the fact that the peptide was first isolated in 1985. Here we sh