Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mckenna Kelly Marie"'
Autor:
Mark D. Pegram, Po Yi Ho, Rosalynd Upton, Kevin S. Kao, Benyamin Rosental, Michal Caspi Tal, Mckenna Kelly Marie, Tal Raveh, Stephen B. Willingham, Dongdong Feng, Jens-Peter Volkmer, Allison Banuelos, Tanuka Biswas, Irving L. Weissman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This study demonstrates the efficacy of combining macrophage-checkpoint inhibition with tumor-specific antibodies for cancer immunotherapy. The combination of anti-CD47 (magrolimab) and anti-HER2 (trastuzumab) antibodies eliminated HER2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b86c70a3c209942c00774efc9102ada
https://doi.org/10.1073/pnas.2026849118
https://doi.org/10.1073/pnas.2026849118
Autor:
Jens-Peter Volkmer, Chiyuan Amy Zhang, Kathleen E. Mach, Eben L. Rosenthal, Bernhard Kiss, Joseph C. Liao, Nynke S. van den Berg, Mckenna Kelly Marie, Robert Ertsey, Irving L. Weissman
Publikováno v:
Clinical Cancer Research. 25:3561-3571
Purpose: Near-infrared photoimmunotherapy (NIR-PIT) is a localized molecular cancer therapy combining a photosensitizer-conjugated mAb and light energy. CD47 is an innate immune checkpoint widely expressed on bladder cancer cells, but absent from lum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148bd325301a5d704a6027fd8b254e35
https://doi.org/10.1158/1078-0432.ccr-18-3267
https://doi.org/10.1158/1078-0432.ccr-18-3267
Autor:
Phung Gip, Irving L. Weissman, Yoko Kojima, Richard I. Sherwood, Richard A. Young, Brian J. Abraham, Angera H. Kuo, Michael F. Clarke, Stephen B. Willingham, Mark A. Zarnegar, Po Ho, George Somlo, Mckenna Kelly Marie, Paola Betancur, Ying Y. Yiu, Nicholas J. Leeper, Tomek Swigut, Farnaz Khameneh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature
Nature
CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402a66da7a79199eaa5e7e9ad1eb73ec
https://doaj.org/article/78521d1c01db4a828a254b9785273b10
https://doaj.org/article/78521d1c01db4a828a254b9785273b10
Autor:
Mckenna Kelly Marie, Ying Y. Yiu, Amira A. Barkal, James Y. Chen, Jonathan M. Tsai, Maxim Markovic, Robin Z. Cheng, Aaron M. Ring, Kevin S. Kao, Po Yi Ho, Irving L. Weissman, Kipp Weiskopf, Roy Louis Maute, Layla J. Barkal, Benyamin Rosental, Benson M. George, Nan Guo Ring, Sydney Gordon
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages and innate cell lineages. Here we found a central role for major histocompatibility comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d335bf1f644a5567665a164740c8bb
https://europepmc.org/articles/PMC5832354/
https://europepmc.org/articles/PMC5832354/
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Aaron M. Ring, David Lowery, Amira A. Barkal, Jaime F. Modiano, Daisuke Ito, Katie L. Anderson, Kristin Bloink, Sarah Rue, Irving L. Weissman, Hirotaka Tomiyasu, Mckenna Kelly Marie, Timothy O'Brien, Ingrid Cornax, Jem A. Efe, Peter J. Schnorr, Susan S. Prohaska, M. Gerard O'Sullivan, Kipp Weiskopf
Publikováno v:
Cancer immunology research. 4(12)
Cancer immunotherapies hold much promise, but their potential in veterinary settings has not yet been fully appreciated. Canine lymphomas are among the most common tumors of dogs and bear remarkable similarity to human disease. In this study, we exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e159913428821927ce15a2985577541f
https://pubmed.ncbi.nlm.nih.gov/27856424
https://pubmed.ncbi.nlm.nih.gov/27856424
Autor:
Chris H. Takimoto, Jiaqi Duan, Kavitha Sompalli, Mark P. Chao, Timothy S Choi, Lynette Brown, Kyle Elrod, Ravindra Majeti, Jie Liu, Jennifer J. Stewart, Jens-Peter Volkmer, Mckenna Kelly Marie, James Y. Chen, Stanley L. Schrier, Paresh Vyas, Irving L. Weissman
Publikováno v:
Blood. 132:2327-2327
CD47 is an anti-phagocytic (i.e. "don't eat me") signal and macrophage checkpoint that cancer cells utilize to evade innate immunity and establish disease. 5F9 is a humanized IgG4 monoclonal antibody (mAb) that binds to human CD47 and blocks its inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044676e0c2b624d2e5c1edb1297879e3
https://doi.org/10.1182/blood-2018-99-115674
https://doi.org/10.1182/blood-2018-99-115674
Autor:
James Y. Chen, Nan Guo, Phung Gip, Michael Zhang, Siddhartha Mitra, Mckenna Kelly Marie, Samuel H. Cheshier, Jens-Peter Volkmer, Mingye Feng, Rachel Weissman-Tsukamoto, Po Yi Ho, Irving L. Weissman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(7)
Significance Macrophage-mediated programmed cell removal (PrCR) plays an essential role in tumor surveillance and elimination. Blockade of the don't-eat-me signal CD47 on tumor cells allows already expressed eat-me signals to induce PrCR to eliminate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dc67d650526f07b006f843d29798e2
https://pubmed.ncbi.nlm.nih.gov/25646432
https://pubmed.ncbi.nlm.nih.gov/25646432
Autor:
Chen, James Y *, McKenna, Kelly Marie *, Choi, Timothy S *, Duan, Jiaqi *, Brown, Lynette *, Stewart, Jennifer J *, Sompalli, Kavitha *, Vyas, Paresh, Schrier, Stanley, Majeti, Ravindra, Weissman, Irving L, Elrod, Kyle *, Chao, Mark Ping, Takimoto, Chris H, Liu, Jie *, Volkmer, Jens-Peter *
Publikováno v:
In Blood 29 November 2018 132 Supplement 1:2327-2327
Autor:
Chris H. Takimoto, Mark P. Chao, Jie Liu, Irving L. Weissman, Branimir I. Sikic, Ravindra Majeti, Mckenna Kelly Marie, Jens-Peter Volkmer, Adriel C. Cha, Dongdong Feng
Publikováno v:
Cancer Immunology Research. 4:PR13-PR13
We have recently discovered that CD47 is a checkpoint of the innate immune system. CD47 is highly expressed on many cancers, allowing evasion of immune surveillance. By binding the inhibitory receptor SIRPα on macrophages and other phagocytes, CD47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c03495ff48d444406bb27538530a6b
https://doi.org/10.1158/2326-6066.imm2016-pr13
https://doi.org/10.1158/2326-6066.imm2016-pr13