Výsledky vyhledávání - "Mckayla Stevens"

Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol

Autor: Siddhi Chitre, Anne-Marie Ray, Mckayla Stevens, Emma H. Doud, Hope Liechty, Alex Washburn, Katelyn Tepper, Jared Sivinski, Heather M. O'Hagan, Millie M. Georgiadis, Eli Chapman, Steven M. Johnson

Publikováno v: Bioorganicmedicinal chemistry. 75

While many studies have established the importance of protein homeostasis in tumor progression, little effort has been made to examine the therapeutic potential of targeting the HSP60 chaperonin system. In healthy cells, HSP60 is localized to the mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64170a8200acc1dcd918dae6bc00628
https://pubmed.ncbi.nlm.nih.gov/36356534

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Allosteric differences dictate GroEL complementation of E. coli

Autor: Jared Sivinski, Duc Ngo, Christopher J. Zerio, Andrew J. Ambrose, Edmond R. Watson, Lynn K. Kaneko, Marius M. Kostelic, Mckayla Stevens, Anne‐Marie Ray, Yangshin Park, Chunxiang Wu, Michael T. Marty, Quyen Q. Hoang, Donna D. Zhang, Gabriel C. Lander, Steven M. Johnson, Eli Chapman

Publikováno v: FASEB J

GroES/GroEL is the only bacterial chaperone essential under all conditions, making it a potential antibiotic target. Rationally targeting ESKAPE GroES/GroEL as an antibiotic strategy necessitates studying their structure and function. Herein, we outl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fdbcdf0cdf11d1c334ee2fd902172a
https://doi.org/10.1096/fj.202101708rr

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Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

Autor: Anne-Marie Ray, Tanya Parish, Yulia Ovechkina, Jared Sivinski, Steven M. Johnson, Siddhi Chitre, Yangshin Park, Eli Chapman, Mckayla Stevens, James Johnson, Quyen Q. Hoang, Alex Washburn, Sanofar Abdeen

Publikováno v: Bioorg Med Chem Lett

Current treatments for Mycobacterium tuberculosis infections require long and complicated regimens that can lead to patient non-compliance, increasing incidences of antibiotic-resistant strains, and lack of efficacy against latent stages of disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000bc8e2afa8fcd9aff724ab32e262c4
https://doi.org/10.1016/j.bmcl.2019.04.034

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HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

Autor: Sanofar Abdeen, Nilshad Salim, Jared Sivinski, Mckayla Stevens, Siddhi Chitre, Eli Chapman, Anne-Marie Ray, Quyen Q. Hoang, Steven M. Johnson, Alex Washburn, Yangshin Park

Publikováno v: Bioorg Med Chem Lett

All living organisms contain a unique class of molecular chaperones called 60 kDa heat shock proteins (HSP60 – also known as GroEL in bacteria). While some organisms contain more than one HSP60 or GroEL isoform, at least one isoform has always prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf0c41ab3fe19e9b67203627d87ce61
https://doi.org/10.1016/j.bmcl.2019.02.028

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Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL

Autor: Iliya Panfilenko, Christopher J. Zerio, Jason M. Machulis, Yangshin Park, Eli Chapman, Chun-Xiang Wu, Andrew J. Ambrose, Mckayla Stevens, Lynn Kaneko, Steven M. Johnson, Niloufar Mollasalehi, Jared Sivinski, Anne-Marie Ray, Quyen Q. Hoang

Publikováno v: mBio
mBio, Vol 12, Iss 1 (2021)

The GroES/GroEL chaperonin from E. coli has long served as the model system for other chaperonins. This assumption seemed valid because of the high conservation between the chaperonins.
As the GroES/GroEL chaperonin system is the only bacterial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75306fc2ba6b09d71878d59f9c62a71b
https://pubmed.ncbi.nlm.nih.gov/33436430

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Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs

Autor: Siddhi Chitre, Mckayla Stevens, Eli Chapman, Jared Sivinski, Yangshin Park, Anne-Marie Ray, Quyen Q. Hoang, Alex Washburn, Steven M. Johnson, Chris Howe

Publikováno v: Bioorg Med Chem

In two previous studies, we identified compound 1 as a moderate GroEL/ES inhibitor with weak to moderate antibacterial activity against Gram-positive and Gram-negative bacteria including Bacillus subtilis, methicillin-resistant Staphylococcus aureus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a9b20c557c56eae7acde5fd5c05616
https://europepmc.org/articles/PMC7914298/

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Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)

Autor: Yangshin Park, Anne-Marie Ray, Peter G. Schultz, Quyen Q. Hoang, Nilshad Salim, Steven M. Johnson, Andrew J. Ambrose, Najiba Mammadova, Corey M. Summers, Eli Chapman, Trent Kunkle, Mckayla Stevens, Sanofar Abdeen, Arthur L. Horwich

Publikováno v: Journal of Medicinal Chemistry. 61:7345-7357

Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-symmetrical bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asymmetric a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f789eb0213fc8a1e401a5da134cce909
https://doi.org/10.1021/acs.jmedchem.8b00989

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Resolving the anomaly of Lomatium anomalum: discovery of a new species in southwestern Idaho (U.S.A.) Lomatium andrusianum (Apiaceae)

Autor: James F. Smith, Donald H. Mansfield, Mary Ann Feist, Mckayla Stevens

Publikováno v: Journal of the Botanical Research Institute of Texas. 12:1-15

Apparent polyphyly within the unresolved clade of Lomatium (Apiaceae) containing L. triternatum, L. anomalum, L. thompsonii, and L. packardiae suggests conflict among current taxonomic classification schemes. To recover this clade and more clearly de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::789cc8d34f3dd68cee2a679dcad9f3ed
https://doi.org/10.17348/jbrit.v12.i1.904

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