Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Mcintosh Joel"'
Autor:
Zhang, Deyi, Harris, Hailey M., Chen, Jonathan, Judy, Jen, James, Gabriella, Kelly, Aileen, McIntosh, Joel, Tenn-McClellan, Austin, Ambing, Eileen, Tan, Ying Siow, Lu, Hao, Gajewski, Stefan, Clifton, Matthew C., Yung, Stephanie, Robbins, Daniel W., Pirooznia, Mehdi, Skånland, Sigrid S., Gaglione, Erika, Mhibik, Maissa, Underbayev, Chingiz, Ahn, Inhye E., Sun, Clare, Herman, Sarah E. M., Noviski, Mark, Wiestner, Adrian ∗
Publikováno v:
In Blood 30 March 2023 141(13):1584-1596
Akademický článek
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Autor:
Sundaram, Aparna, Chen, Chun, Isik Reed, Nilgun, Liu, Sean, Ki Yeon, Seul, McIntosh, Joel, Tang, You-Zhi, Yang, Hyunjun, Adler, Marc, Beresis, Richard, Seiple, Ian B., Sheppard, Dean, DeGrado, William F., Jo, Hyunil
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 November 2020 30(22)
Akademický článek
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Autor:
Jennifer Tung, Luz Perez, Timothy Ingallinera, Jordan Ye, Aileen Kelly, May Tan, Ge Peng, Sasha Borodovsky, Zef Konst, Austin Tenn-McClellan, Ryan Rountree, Steve Basham, Jeffrey H. Wu, Jenny McKinnell, Dahlia Weiss, Arthur T. Sands, Cristiana Guiducci, Mark Noviski, Mcintosh Joel, Dane E Karr, Janine Powers, Daniel W. Robbins, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic
Publikováno v:
Blood. 136:34-34
Bruton's tyrosine kinase (BTK) plays a key role in cell survival in B cell malignancies, such as chronic lymphocytic leukemia (CLL). Covalent inhibitors of BTK, such as ibrutinib and acalabrutinib, while effective, have been associated with the occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492f0dbdb2ad9ad3c62ea1d2da14dc82
https://doi.org/10.1182/blood-2020-141461
https://doi.org/10.1182/blood-2020-141461
Autor:
Jason Duquette, Xin Huang, Dongyin Yu, Yun Ling, Jing Zhou, Yu Chung Wang, Daqing Sun, Sarah Wortman, John Eksterowicz, Qiuping Ye, Min Jiang, Jonathan D. Oliner, Lixia Jin, Alexander M. Long, Ana Z. Gonzalez, Peter Yakowec, Yihong Li, Steven H. Olson, Anne Y. Saiki, Hilary Plake Beck, Yosup Rew, Lawrence R. McGee, Julio C. Medina, Jonathan B. Houze, Jiasheng Fu, Jude Canon, Mcintosh Joel, Ada Chen, Brian M. Fox, Mei-Chu Lo, Xuelei Yan, Paul L. Shaffer, Zhihong Li, Tao Osgood, Xiaoning Zhao
Publikováno v:
Journal of Medicinal Chemistry. 57:10499-10511
Structure-based rational design and extensive structure-activity relationship studies led to the discovery of AMG 232 (1), a potent piperidinone inhibitor of the MDM2-p53 association, which is currently being evaluated in human clinical trials for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6411aa1211e82e797ec19f5aeedd623
https://doi.org/10.1021/jm501550p
https://doi.org/10.1021/jm501550p
Autor:
Judy M. Suh, Sandra Frauchiger, Michael Soth, Xiaochun Han, Ronald J. Hill, Buelent Kocer, Taygerly Joshua Paul Gergely, Jaehyeon Park, Hong Jun-Bae, Andreas Kuglstatter, Rama K. Kondru, Tobias Gabriel, Renee Litman, Yan Lou, Zachary Kevin Sweeney, Mcintosh Joel, Nolan James Dewdney, Dana Davis, David Michael Goldstein, Timothy D. Owens, Hasim Zecic, Keshab Sarma
Publikováno v:
Journal of Medicinal Chemistry. 58:512-516
Structure-based drug design was used to guide the optimization of a series of selective BTK inhibitors as potential treatments for Rheumatoid arthritis. Highlights include the introduction of a benzyl alcohol group and a fluorine substitution, each o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2706725af4b785142b07ad80c3bfd24
https://doi.org/10.1021/jm500305p
https://doi.org/10.1021/jm500305p
Autor:
Ada Chen, Steven H. Olson, Alexander M. Long, John Eksterowicz, Michael D. Bartberger, Jing Zhou, Yosup Rew, Lawrence R. McGee, Mei-Chu Lo, Anne Y. Saiki, Dongyin Yu, Jason Duquette, Xuelei Yan, Ana Z. Gonzalez, Hilary Plake Beck, Jonathan B. Houze, Yun Ling, Mcintosh Joel, Jonathan D. Oliner, Sarah Wortman, Jude Canon, Daqing Sun, Dustin McMinn, Brian M. Fox, Paul L. Shaffer, Xiaoning Zhao, Tao Osgood, Lixia Jin, Xin Huang, Zhihong Li, David Chow, Qiuping Ye, Yihong Li, Jiasheng Fu, Peter Yakowec, Julio C. Medina
Publikováno v:
Journal of Medicinal Chemistry. 57:2472-2488
We previously reported the discovery of AMG 232, a highly potent and selective piperidinone inhibitor of the MDM2-p53 interaction. Our continued search for potent and diverse analogues led to the discovery of novel morpholinone MDM2 inhibitors. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1d3d1db724c5401afea1de13f776b9
https://doi.org/10.1021/jm401767k
https://doi.org/10.1021/jm401767k
Autor:
Christoph W. Zapf, May Tan, Mario G. Cardozo, Ge Peng, Jennifer Tung, Mcintosh Joel, Arthur T. Sands, Ryan Rountree, Zef Konst, Jordan Ye, Aileen Kelly, Jeffrey H. Wu, Luz Perez, Neil Bence, Timothy Ingallinera, Dahlia Weiss, Mark Noviski, Steve Basham, Austin Tenn-McClellan, Jenny McKinnell, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic, Daniel W. Robbins, Dane E Karr
Publikováno v:
Blood. 134:3805-3805
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor signaling and is involved in B cell development and function. BTK plays a crucial role in cell survival in B cell malignancies such as Chronic Lymphocytic Leukemia (CLL), and covale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b95ae450ec2bc4afe8f06a32c74d624
https://doi.org/10.1182/blood-2019-129262
https://doi.org/10.1182/blood-2019-129262
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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