Hepatic 5α-reduced glucocorticoids : modulators of glucocorticoid receptor activation in obesity

Autor: McInnes, Kerry J.

In obese versus lean Zucker rats, hepatic 5α-reductase type 1 mRNA expression and protein levels were increased. They also had increased activity of hepatic 5β-reductase activity. By contrast, 3α-hydroxysteroid dehydrogenase mRNA expression was un

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.666258

5α-Reduced Glucocorticoids, Novel Endogenous Activators of the Glucocorticoid Receptor

Autor: McInnes, Kerry J., Kenyon, Christopher J., Chapman, Karen E., Livingstone, Dawn E.W., Macdonald, Linsay J., Walker, Brian R., Andrew, Ruth ^‡

Publikováno v: In Journal of Biological Chemistry May 2004 279(22):22908-22912

Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men

Autor: Gibb, Fraser W., Homer, Natalie Z.m., Faqehi, Abdullah M.m., Upreti, Rita, Livingstone, Dawn E., Mcinnes, Kerry J., Andrew, Ruth, Walker, Brian R.

Publikováno v: Gibb, F W, Homer, N Z M, Faqehi, A M M, Upreti, R, Livingstone, D E, Mcinnes, K J, Andrew, R & Walker, B R 2016, ' Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men ', Journal of Clinical Endocrinology & Metabolism, pp. jc.2015-4146 . https://doi.org/10.1210/jc.2015-4146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::d446ca1284693ddbda728592148828d9
https://hdl.handle.net/20.500.11820/7e164eab-5496-4031-b8ab-01880946e24f

Association of 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity with Estrogen Receptor β in Adipose Tissue from Postmenopausal Women

Autor: McInnes, Kerry J, Andersson, Therése C, Šimonytė, Kotryna, Söderström, Ingegerd, Mattsson, Cecilia, Seckl, Jonathan R, Olsson, Tommy

11β-Hydroxysteroid dehydrogenase type I (11βHSD1) regenerates active cortisol from inert cortisone in adipose tissue. Elevated adipose tissue 11βHSD1 activity is observed in obese humans and rodents, where it is linked to obesity and its metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69219cdd1caf4d5703902065963433dd
https://europepmc.org/articles/PMC3510652/

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