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C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation

Autor: Swinkels, Maurice, Zhang, Justine H, Tilakaratna, Viranga, Black, Graeme, Perveen, Rahat, Mcharg, Selina, Inforzato, Antonio, Day, Anthony, Clark, Simon

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports, 8:1643. Nature Publishing Group
Swinkels, M, Zhang, J H, Tilakaratna, V, Black, G, Perveen, R, Mcharg, S, Inforzato, A, Day, A & Clark, S 2018, ' C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation ', Scientific Reports . https://doi.org/10.1038/s41598-017-18395-7

Retinal inflammation plays a key role in the progression of age-related macular degeneration (AMD), a condition that leads to loss of central vision. The deposition of the acute phase pentraxin C-reactive protein (CRP) in the macula activates the com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::22a8934e4872733fdaa181f330f24888
http://link.springer.com/article/10.1038/s41598-017-18395-7

Genetic risk of AMD at both the CFH and ARMS2/HTRA1 loci is associated with increased protease expression and activity in human Bruch’s membrane/inner choroid

Autor: Day, Anthony, Bishop, Paul, Mcharg, Selina, Bayatti, Nadhim, Perveen, Rahat, Black, Graeme, Dowsey, Andrew, Clark, Simon, Unwin, Richard

Publikováno v: Day, A, Bishop, P, Mcharg, S, Bayatti, N, Perveen, R, Black, G, Dowsey, A, Clark, S & Unwin, R 2019, ' Genetic risk of AMD at both the CFH and ARMS2/HTRA1 loci is associated with increased protease expression and activity in human Bruch’s membrane/inner choroid. ', Investigative ophthalmology & visual science, vol. 60, no. 9, pp. 2814 . https://doi.org/https://iovs.arvojournals.org/article.aspx?articleid=2742846&resultClick=1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::917f990a21fdb9d941f5e155ab9893d0
https://www.research.manchester.ac.uk/portal/en/publications/genetic-risk-of-amd-at-both-the-cfh-and-arms2htra1-loci-is-associated-with-increased-protease-expression-and-activity-in-human-bruchs-membraneinner-choroid(d02a3a97-4fb3-4003-b45c-e8d38197956e).html

Bruch's membrane compartmentalises complement regulation in the eye with implications for therapeutic design in age-related macular degeneration

Autor: Clark, Simon, Mcharg, Selina, Tilakaratna, Viranga, Brace, Nicole, Bishop, Paul

Publikováno v: Clark, S, Mcharg, S, Tilakaratna, V, Brace, N & Bishop, P 2017, ' Bruch's membrane compartmentalises complement regulation in the eye with implications for therapeutic design in age-related macular degeneration. ', Frontiers in Immunology . https://doi.org/10.3389/fimmu.2017.01778

Age-related macular degeneration (AMD) is the leading cause of blindness in the western world and affects nearly 200 million peopleglobally. Local inflammation driven by complement system dysregulation is currently a therapeutic target. Bruch’s mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::6df18e21c1cbf4fa98bc30b558e8bbf0
https://www.research.manchester.ac.uk/portal/en/publications/bruchs-membrane-compartmentalises-complement-regulation-in-the-eye-with-implications-for-therapeutic-design-in-agerelated-macular-degeneration(8bf2a6c9-0e1b-474a-a603-66645e88f2a0).html

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