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Akademický článek

Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first-in-human, Phase 1b, open-label, single-dose study.

Autor: Tripathi SS; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust Preston UK., Sneath R; NIHR Coventry and Warwickshire Clinical Research Facility University Hospitals Coventry and Warwickshire NHS Trust Coventry UK., Golash A; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust Preston UK., Desai P; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust Preston UK., McHale D; Weatherden Ltd London UK., Guest S; Persica Pharmaceuticals Ltd Canterbury Kent UK., Brindley C; Kinetassist Ltd Quothquan UK., Cummings P; PJC Pharma Consulting Ltd Suffolk UK., Smith S; PJC Pharma Consulting Ltd Suffolk UK., Stroud C; Micron Research Ltd Ely UK., Scott G; GS Drug Development Sciences Ltd East Grinsted UK., Ruston S; Persica Pharmaceuticals Ltd Canterbury Kent UK., Czaplewski L; Persica Pharmaceuticals Ltd Canterbury Kent UK.

Publikováno v: JOR spine [JOR Spine] 2024 Nov 14; Vol. 7 (4), pp. e70009. Date of Electronic Publication: 2024 Nov 14 (Print Publication: 2024).

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Akademický článek

Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses - a randomized, placebo-controlled clinical trial.

Autor: Eveleens Maarse BC; Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands.; Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Ronner MN; Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands.; Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Jansen MAA; Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Niemeyer-van der Kolk T; Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands.; Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., In 't Veld AE; Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands.; Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Klaassen ES; Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Ahmad S; Evelo Biosciences Inc., One Kendall Square, Building 600/700, Suite 7-201, Cambridge, MA, USA.; Veramed, 5th Floor Regal House, 70 London Road, Twickenham, TW1 3QS, UK., Itano A; Evelo Biosciences Inc., One Kendall Square, Building 600/700, Suite 7-201, Cambridge, MA, USA., McHale D; Evelo Biosciences Inc., One Kendall Square, Building 600/700, Suite 7-201, Cambridge, MA, USA., Moerland M; Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands. mmoerland@chdr.nl.; Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. mmoerland@chdr.nl.

Publikováno v: Immunologic research [Immunol Res] 2024 Aug; Vol. 72 (4), pp. 776-787. Date of Electronic Publication: 2024 May 15.

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Akademický článek

A randomized, double-blinded, phase 2 trial of EDP1815, an oral immunomodulatory preparation of Prevotella histicola , in adults with mild-to-moderate plaque psoriasis.

Autor: Ehst BD; Oregon Medical Research Center, Portland, OR, United States., Strober B; Yale University School of Medicine, New Haven, CT, United States.; Central Connecticut Dermatology, Cromwell, CT, United States., Blauvelt A; Oregon Medical Research Center, Portland, OR, United States., Maslin D; Evelo Biosciences, Inc., Cambridge, MA, United States., Macaro D; Evelo Biosciences, Inc., Cambridge, MA, United States., Carpenter N; Evelo Biosciences, Inc., Cambridge, MA, United States., Bodmer M; Evelo Biosciences, Inc., Cambridge, MA, United States., McHale D; Evelo Biosciences, Inc., Cambridge, MA, United States.

Publikováno v: Frontiers in medicine [Front Med (Lausanne)] 2024 May 15; Vol. 11, pp. 1292406. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).

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Akademický článek

Health Insurance Coverage Predicts Health Care Use among Latine Immigrants in Two Policy Contexts.

Autor: Morrissey T, Castleberry NM, McHale D, Sol C, Dondero M, Yamanis T

Publikováno v: Journal of health care for the poor and underserved [J Health Care Poor Underserved] 2024; Vol. 35 (2), pp. 481-502.

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A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population

Autor: Praet, C., Urban, T.J., Chamberlain, C., McHale, D., Shea, P.R., White, I.R., Maia, J.M., Xie, P., Kleinstein, S.E., Goldstein, D.B.

Certolizumab pegol (CZP) is a PEGylated Fc-free tumor necrosis factor (TNF) inhibitor antibody approved for use in the treatment of rheumatoid arthritis (RA), Crohn's disease, psoriatic arthritis, axial spondyloarthritis and psoriasis. In a clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d369bdbf685d4ef7695e4653ca12b44

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Akademický článek

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.

Autor: Czaplewski LG; Persica Pharmaceuticals Ltd, 7 Denne Hill Business Centre, Womenswold, Canterbury, Kent, CT4 6HD, UK. lloyd.czaplewski@persicapharmaceuticals.com., Rimmer O; Veramed Ltd, 5th Floor Regal House, 70 London Road, Twickenham, TW1 3QS, UK., McHale D; Weatherden Ltd, 71 Kingsway, London, WC2B 6ST, UK., Laslett M; Mark Laslett, Physiotherapy Specialist, The Sports Clinic, 156 Bealey Ave., Christchurch, 8014, New Zealand.

Publikováno v: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2023 May 12; Vol. 18 (1), pp. 351. Date of Electronic Publication: 2023 May 12.

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Akademický článek

Clinical translation of anti-inflammatory effects of Prevotella histicola in Th1, Th2, and Th17 inflammation.

Autor: Itano A; Evelo Biosciences, Cambridge, MA, United States., Maslin D; Evelo Biosciences, Cambridge, MA, United States., Ramani K; Evelo Biosciences, Cambridge, MA, United States., Mehraei G; Evelo Biosciences, Cambridge, MA, United States., Carpenter N; Evelo Biosciences, Cambridge, MA, United States., Cormack T; Evelo Biosciences, Cambridge, MA, United States., Saghari M; Centre for Human Drug Research (CHDR), Leiden, Netherlands., Moerland M; Centre for Human Drug Research (CHDR), Leiden, Netherlands., Troy E; Evelo Biosciences, Cambridge, MA, United States., Caffry W; Evelo Biosciences, Cambridge, MA, United States., Wardwell-Scott L; Evelo Biosciences, Cambridge, MA, United States., Abel S; Evelo Biosciences, Cambridge, MA, United States., McHale D; Evelo Biosciences, Cambridge, MA, United States., Bodmer M; Evelo Biosciences, Cambridge, MA, United States.

Publikováno v: Frontiers in medicine [Front Med (Lausanne)] 2023 May 05; Vol. 10, pp. 1070433. Date of Electronic Publication: 2023 May 05 (Print Publication: 2023).

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Clinical spectrum of STX1B-related epileptic disorders

Publikováno v: Wolking, S, May, P, Mei, D, Møller, R S, Balestrini, S, Helbig, K L, Altuzarra, C D, Chatron, N, Kaiwar, C, Stöhr, K, Widdess-Walsh, P, Mendelsohn, B A, Numis, A, Cilio, M R, Van Paesschen, W, Svendsen, L L, Oates, S, Hughes, E, Goyal, S, Brown, K, Sifuentes Saenz, M, Dorn, T, Muhle, H, Pagnamenta, A T, Vavoulis, D V, Knight, S J L, Taylor, J C, Canevini, M P, Darra, F, Gavrilova, R H, Powis, Z, Tang, S, Marquetand, J, Armstrong, M, McHale, D, Klee, E W, Kluger, G J, Lowenstein, D H, Weckhuysen, S, Pal, D K, Helbig, I, Guerrini, R, Thomas, R H, Rees, M I, Lesca, G, Sisodiya, S M, Weber, Y G, Lal, D, Marini, C, Lerche, H & Schubert, J 2019, ' Clinical spectrum of STX1B-related epileptic disorders ', Neurology, vol. 92, no. 11, pp. e1238-e1249 . https://doi.org/10.1212/WNL.0000000000007089
Neurology

OBJECTIVE: The aim of this study was to expand the spectrum of epilepsy syndromes related to STX1B, encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants. METHODS:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::64082d157eff5d0457b6e34c87e55deb
http://ora.ox.ac.uk/objects/uuid:

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