Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mcgee John Hanney"'
Autor:
Seung-Joo Lee, Gregory L. Verdine, Mcgee John Hanney, So Youn Shim, Paige K. Swanson, Michael A. Durney, Sam Y. Jiang
Publikováno v:
The Journal of Biological Chemistry
The Ras proteins are aberrantly activated in a wide range of human cancers, often endowing tumors with aggressive properties and resistance to therapy. Decades of effort to develop direct Ras inhibitors for clinical use have thus far failed, largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c823f69808dd9f4fe65d277cac9c472
https://doi.org/10.1074/jbc.m117.816348
https://doi.org/10.1074/jbc.m117.816348
Autor:
Mcgee John Hanney, Adam Levinson, Ronald C. Hendrickson, Samuel J. Danishefsky, Andrew G. Roberts, Gregory L. Verdine, Michael T. Peterson, Gardner S. Creech, Ting Wang
The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17395db05b26ca7eeb19b3c95af5528d
https://europepmc.org/articles/PMC5606205/
https://europepmc.org/articles/PMC5606205/
Autor:
K. Dane Wittrup, Carla Mattos, Ryan Knihtila, Monique J. Kauke, Jillian A. Parker, Michael W. Traxlmayr, Mcgee John Hanney, Greg Verdine, Jonathan D. Kiefer
Publikováno v:
Scientific Reports, 7
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefbbece62af221d8182cd4b72987666
Autor:
McGee, John Hanney
In recent years, great advances have been made in understanding the molecular causes of human disease, but our ability to exploit these discoveries for therapeutic benefit is frequently limited by the inability to make drugs that target the processes
Externí odkaz:
http://dissertations.umi.com/gsas.harvard:10915
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10947514
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10947514