Low Levels of Perforin Expression in CD8+ T Lymphocyte Granules in Lymphoid Tissue during Acute Human Immunodeficiency Virus Type 1 Infection

Autor: Andersson, J., Kinloch, S., Sonnerborg, A., Jakob Nilsson, Fehniger, Te, Spetz, Al, Behbahani, H., Goh, Le, Mcdade, H., Gazzard, B., Stellbrink, H., Cooper, D., Perrin, L.

Publikováno v: Karolinska Institutet

Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte (CTL) responses are detectable shortly after the acute phase of HIV infection, but they cannot control viral replication and prevent development of chronic immune suppression. This ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::efb0db0e2427536806b2706a83e495ed
http://doc.rero.ch/record/295784/files/185-9-1355.pdf

Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection

Autor: Cavert, W., Notermans, D. W., Staskus, K., Wietgrefe, S. W., Zupancic, M., Gebhard, K., Henry, K., Zhang, Z. Q., Mills, R., McDade, H., Schuwirth, C. M., Goudsmit, J., Danner, S. A., Haase, A. T.

Publikováno v: Science, 276, 960-964. American Association for the Advancement of Science
Cavert, W, Notermans, D W, Staskus, K, Wietgrefe, S W, Zupancic, M, Gebhard, K, Henry, K, Zhang, Z Q, Mills, R, McDade, H, Goudsmit, J, Danner, S A & Haase, A T 1997, ' Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection ', Science, vol. 276, no. 5314, pp. 960-964 . https://doi.org/10.1126/science.276.5314.960
Science, 276(5314), 960-964. American Association for the Advancement of Science

In lymphoid tissue, where human immunodeficiency virus–type 1 (HIV-1) is produced and stored, three-drug treatment with viral protease and reverse transcriptase inhibitors markedly reduced viral burden. This was shown by in situ hybridization and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd0c6b3c311a718bf268cc34b4bd82c
http://www.scopus.com/inward/record.url?scp=15144342918&partnerID=8YFLogxK

Zidovudine, didanosine, and zalcitabine in the treatment of HIV infection: meta-analyses of the randomised evidence. HIV Trialists' Collaborative Group

Autor: Abrams, D, Allan, D, Antunes, F, Breckenridge, A, Bruun, J, Cameron, W, Carbon, C, Chalmers, I, Chang, H, Chodakewitz, J, Clendenin, N, Clumeck, N, Collier, A, Collins, G, Cooper, E, Cooper, D, Danner, S, D'Aquila, R, DeGruttola, V, DeMasi, R, Dee, L, Deyton, L, Dixon, D, Farthing, C, Feinberg, J, Fischl, M, Flepp, M, Gartland, M, Gatell, J, Gazzard, B, Goebel, F, Gotzsche, P, Gringeri, A, Hall, D, Hamilton, J, Hammer, S, Hartigan, P, Heath-Chiozzi, M, Henry, K, Hill, A, Hirschel, B, Ioannidis, J, Kahn, J, Katlama, C, Katzenstein, D, Killen, J, King, E, de Loes, SK, Kravcik, S, Lange, J, Leavitt, R, Leonard, J, Maeland, A, Mannucci, P, Mathiesen, L, McDade, H, Meibohn, A, Melander, H, Merigan, T, Mulder, J, Myers, M, Neaton, J, Nessling, M, Perrin, L, Pettinelli, C, Phair, J, Phillips, A, Pinching, A, Poppa, A, Power, L, Reiss, P, Richman, D, Rooney, J, Rousseau, F, Rutherford, G, Salgo, M, Sandstrom, E, Saravolatz, L, Savidge, G, Schnittman, S, Schooley, R, Seligmann, M, Simberkoff, M, Skowron, G, Slade, P, Smith, D, Smith, RP, Soriano, V, Stanley, K, Stingl, G, Stoffels, P, Struthers, L, Tierney, C, Thompson, M, Van der Broeck, R, Van Leeuven, R, Van Weverling, G, Veenstra, J, Vella, S, Volberding, P, Weber, J, Winslow, D, Yeni, P, Yeo, J, Dormont, J, Sande, M, Weller, I, Babiker, A, Collins, R, Darbyshire, J, Duncan, W, Foulkes, M, Hughes, M, Peto, R, Peto, T, Walker, S, Grp, HIVTC

Publikováno v: Lancet. 353(9169)

BACKGROUND: To assess the effects of zidovudine, didanosine, and zalcitabine on HIV disease progression and survival, we undertook meta-analyses of individual patient data and tabular data from all randomised trials that compared these agents. METHOD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::4ed6d8da2b08a8cbc7dd028f2bb13c3d
http://ora.ox.ac.uk/objects/uuid:87578015-55c8-4841-8a9f-6ec439487f4d

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