Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mccowan Jefferson Ray"'
Autor:
Edward C R Smith, William Thomas Mcmillen, Mccowan Jefferson Ray, Lei Yan, Mort Nicholas A, Michael L. Jones, Bryan D. Anderson, Robert M. Campbell, Faming Zhang, John W. Lampe, Leonard C Weir, David Kent Herron, Stephen Parsons, Jonathan Michael Yingling, Beight Douglas W, J. Scott Sawyer, Michal Vieth
Publikováno v:
Journal of Medicinal Chemistry. 46:3953-3956
Pyrazole-based inhibitors of the transforming growth factor-beta type I receptor kinase domain (TbetaR-I) are described. Examination of the SAR in both enzyme- and cell-based in vitro assays resulted in the emergence of two subseries featuring differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79265d282a8256455dee4b376e4bc42
https://doi.org/10.1021/jm0205705
https://doi.org/10.1021/jm0205705
Publikováno v:
Journal of Medicinal Chemistry. 34:1505-1508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7345b1b5cb938cf2a3185d7c4ff6fefe
https://doi.org/10.1021/jm00108a040
https://doi.org/10.1021/jm00108a040
Autor:
Jack B. Deeter, Norman R. Mason, Laurane G. Mendelsohn, Yu Melvin Joseph, Mccowan Jefferson Ray
Publikováno v:
Journal of medicinal chemistry. 35(14)
Compounds exemplified by 2-[2-(5-bromo-1H-indol-3-yl)ethyl]-3-[3-(1- methylethoxy)phenyl]-4(3H)-quinazolinone (3, IC50 = 0.0093 microM using mouse brain membranes) represent a structurally novel series of non-peptide cholecystokinin B receptor ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35097732a2346c9b2b297fe9f45ad9f9
https://pubmed.ncbi.nlm.nih.gov/1635055
https://pubmed.ncbi.nlm.nih.gov/1635055
Autor:
Virginia L. Wyss, Yu Melvin Joseph, Mitchell I. Steinberg, Mccowan Jefferson Ray, Sally A. Wiest, Jong S. Horng
Publikováno v:
Journal of medicinal chemistry. 33(1)
Prazosin (25 microM) was found to increase 125I-labeled rat atrial natriuretic peptide ([125I]rANP) receptor binding by 50% (SC50) in bovine adrenal zona glomerulosa membranes. A series of 2,4-disubstituted quinazolines was prepared in order to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33abaf3fe033b1b8a4486096bbd21e3a
https://pubmed.ncbi.nlm.nih.gov/1967315
https://pubmed.ncbi.nlm.nih.gov/1967315
Publikováno v:
The Journal of Organic Chemistry. 52:678-681
Preparation de phenyl-2-, aryl-2- et [thienyl-2]-2 allylamines par copulation entre des reactifs de Grignard et le (chloro-2' allyl-2 tetramethyl-1,1,3,3) azadisilolanne-2,1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::043d129400f6cf54a758adad26339cbc
https://doi.org/10.1021/jo00380a036
https://doi.org/10.1021/jo00380a036
Publikováno v:
Synthetic Communications. 16:1551-1556
Metalated veratraldehyde and veratrole were quenched with perchloryl fluoride to provide one-step syntheses of 2-fluoroveratraldehyde and 2-fluoroveratrole, respectively. Previous syntheses of these precursors to 2-fluorodopamine and 5-fluoronorepine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7f8688599d974904f3758be35d6bc6
https://doi.org/10.1080/00397918608056408
https://doi.org/10.1080/00397918608056408
Publikováno v:
ChemInform. 18
A four-step synthesis of 2-chlorodopamine (2b) is presented as well as methods for the syntheses of the N-methyl, ethyl, and n-propyl analogues (2c-e). Compounds 2b and 2c were essentially equipotent to dopamine for increasing renal blood flow in ane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88c91968c195debdd9a22083904149a8
https://doi.org/10.1002/chin.198706141
https://doi.org/10.1002/chin.198706141
Publikováno v:
ChemInform. 18
Preparation de phenyl-2-, aryl-2- et [thienyl-2]-2 allylamines par copulation entre des reactifs de Grignard et le (chloro-2' allyl-2 tetramethyl-1,1,3,3) azadisilolanne-2,1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5defbb14d1ae2ab3b92797f4689064
https://doi.org/10.1002/chin.198733181
https://doi.org/10.1002/chin.198733181
Publikováno v:
Journal of medicinal chemistry. 29(9)
A four-step synthesis of 2-chlorodopamine (2b) is presented as well as methods for the syntheses of the N-methyl, ethyl, and n-propyl analogues (2c-e). Compounds 2b and 2c were essentially equipotent to dopamine for increasing renal blood flow in ane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdcce9480863db3bb42c3aa2ad5b237
https://pubmed.ncbi.nlm.nih.gov/3528490
https://pubmed.ncbi.nlm.nih.gov/3528490
Publikováno v:
ChemInform. 18
Metalated veratraldehyde and veratrole were quenched with perchloryl fluoride to provide one-step syntheses of 2-fluoroveratraldehyde and 2-fluoroveratrole, respectively. Previous syntheses of these precursors to 2-fluorodopamine and 5-fluoronorepine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941f9f83b99fa37871fb6e0ed25b25d8
https://doi.org/10.1002/chin.198714135
https://doi.org/10.1002/chin.198714135