Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mcbride, John M"'
Autor:
McBride, John M, Kim, Nahie, Nishikawa, Yuri, Saadakeev, Mekhmed, Pearce, Marcus T, Tlusty, Tsvi
The number of possible melodies is unfathomably large, yet despite this virtually unlimited potential for melodic variation, melodies from different societies can be surprisingly similar. The motor constraint hypothesis accounts for certain similarit
Externí odkaz:
http://arxiv.org/abs/2408.12635
The standard theory of musical scales since antiquity has been based on harmony, rather than melody. Some recent analyses support either view, and we lack a comparative test on cross-cultural data. We address this longstanding problem through a rigor
Externí odkaz:
http://arxiv.org/abs/2408.12633
Despite recent breakthroughs in understanding how protein sequence relates to structure and function, considerably less attention has been paid to the general features of protein surfaces beyond those regions involved in binding and catalysis. This p
Externí odkaz:
http://arxiv.org/abs/2407.14063
Autor:
Mcbride, John M, Tlusty, Tsvi
AI algorithms have proven to be excellent predictors of protein structure, but whether and how much these algorithms can capture the underlying physics remains an open question. Here, we aim to test this question using the Alphafold2 (AF) algorithm:
Externí odkaz:
http://arxiv.org/abs/2311.18222
Autor:
McBride, John M., Tlusty, Tsvi
Proteins are intricate molecular machines whose complexity arises from the heterogeneity of the amino acid building blocks and their dynamic network of many-body interactions. These nanomachines gain function when put in the context of a whole organi
Externí odkaz:
http://arxiv.org/abs/2311.09565
Autor:
McBride, John M., Polev, Konstantin, Abdirasulov, Amirbek, Reinharz, Vladimir, Grzybowski, Bartosz A., Tlusty, Tsvi
AlphaFold2 (AF) is a promising tool, but is it accurate enough to predict single mutation effects? Here, we report that the localized structural deformation between protein pairs differing by only 1-3 mutations -- as measured by the effective strain
Externí odkaz:
http://arxiv.org/abs/2204.06860
Proteins need to selectively interact with specific targets among a multitude of similar molecules in the cell. But despite a firm physical understanding of binding interactions, we lack a general theory of how proteins evolve high specificity. Here,
Externí odkaz:
http://arxiv.org/abs/2202.10698
Scales, sets of discrete pitches that form the basis of melodies, are thought to be one of the most universal hallmarks of music. But we know relatively little about cross-cultural diversity of scales or how they evolved. To remedy this, we assemble
Externí odkaz:
http://arxiv.org/abs/2108.00842
Autor:
McBride, John M, Tlusty, Tsvi
Proteins are translated from the N- to the C-terminus, raising the basic question of how this innate directionality affects their evolution. To explore this question, we analyze 16,200 structures from the protein data bank (PDB). We find remarkable e
Externí odkaz:
http://arxiv.org/abs/2009.13900
Autor:
McBride, John M., Tlusty, Tsvi
Musical scales are used throughout the world, but the question of how they evolved remains open. Some suggest that scales based on the harmonic series are inherently pleasant, while others propose that scales are chosen that are easy to communicate.
Externí odkaz:
http://arxiv.org/abs/1906.06171