WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis.

Autor: Rodríguez Pérez F; Eikon Therapeutics, Hayward, CA, 94545, USA. perezf@eikontx.com., Natwick D; Eikon Therapeutics, Hayward, CA, 94545, USA., Schiff L; Eikon Therapeutics, Hayward, CA, 94545, USA., McSwiggen D; Eikon Therapeutics, Hayward, CA, 94545, USA., Heckert A; Eikon Therapeutics, Hayward, CA, 94545, USA., Huey M; Eikon Therapeutics, Hayward, CA, 94545, USA., Morrison H; Eikon Therapeutics, Hayward, CA, 94545, USA., Loo M; Eikon Therapeutics, Hayward, CA, 94545, USA., Miranda RG; Eikon Therapeutics, Hayward, CA, 94545, USA., Filbin J; Eikon Therapeutics, Hayward, CA, 94545, USA., Ortega J; Eikon Therapeutics, Hayward, CA, 94545, USA., Van Buren K; Eikon Therapeutics, Hayward, CA, 94545, USA., Murnock D; Eikon Therapeutics, Hayward, CA, 94545, USA., Tao A; Eikon Therapeutics, Hayward, CA, 94545, USA., Butler R; Eikon Therapeutics, Hayward, CA, 94545, USA., Cheng K; Eikon Therapeutics, Hayward, CA, 94545, USA., Tarvestad W; Eikon Therapeutics, Hayward, CA, 94545, USA., Zhang Z; Eikon Therapeutics, Hayward, CA, 94545, USA., Gonzalez E; Eikon Therapeutics, Hayward, CA, 94545, USA., Miller RM; Eikon Therapeutics, Hayward, CA, 94545, USA., Kelly M; Eikon Therapeutics, Hayward, CA, 94545, USA., Tang Y; Eikon Therapeutics, Hayward, CA, 94545, USA., Ho J; Eikon Therapeutics, Hayward, CA, 94545, USA., Anderson D; Eikon Therapeutics, Hayward, CA, 94545, USA., Bashore C; Eikon Therapeutics, Hayward, CA, 94545, USA., Basham S; Eikon Therapeutics, Hayward, CA, 94545, USA. bashams@eikontx.com.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 18; Vol. 15 (1), pp. 6059. Date of Electronic Publication: 2024 Jul 18.

Transcriptional condensates: a blessing or a curse for gene regulation?

Autor: Stortz, Martin^1,2 (AUTHOR), Presman, Diego M.^3,4 (AUTHOR) presmandm@fbmc.fcen.uba.ar, Levi, Valeria^1,5 (AUTHOR) vlevi12@gmail.com

Publikováno v: Communications Biology. 2/16/2024, Vol. 7 Issue 1, p1-10. 10p.

Biomolecular Condensates: Structure, Functions, Methods of Research.

Autor: Gorsheneva, Natalia A.¹ (AUTHOR), Sopova, Julia V.¹ (AUTHOR), Azarov, Vladimir V.¹ (AUTHOR), Grizel, Anastasia V.² (AUTHOR) anastasiia.grizel@biosci.gatech.edu, Rubel, Aleksandr A.¹ (AUTHOR) a.rubel@spbu.ru

Publikováno v: Biochemistry (00062979). 2024 Suppl 1, Vol. 89, pS205-S223. 19p.

Protein kinase A and local signaling in cancer.

Autor: Rosenthal, Kacey J., Gordan, John D., Scott, John D.

Publikováno v: Biochemical Journal; Nov2024, Vol. 481 Issue 22, p1659-1677, 19p

RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization.

Autor: Collombet S; European Molecular Biology Laboratory, Heidelberg, Germany., Rall I; European Molecular Biology Laboratory, Heidelberg, Germany., Dugast-Darzacq C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA, USA., Heckert A; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA, USA., Halavatyi A; European Molecular Biology Laboratory, Heidelberg, Germany., Le Saux A; Curie Institute, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne, Paris, France., Dailey G; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA, USA., Darzacq X; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. darzacq@berkeley.edu.; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA, USA. darzacq@berkeley.edu., Heard E; European Molecular Biology Laboratory, Heidelberg, Germany. edith.heard@embl.org.; Curie Institute, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne, Paris, France. edith.heard@embl.org.; College de France, Paris, France. edith.heard@embl.org.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2023 Aug; Vol. 30 (8), pp. 1216-1223. Date of Electronic Publication: 2023 Jun 08.