Inhaled "Muco‐Trapping" Monoclonal Antibody Effectively Treats Established Respiratory Syncytial Virus (RSV) Infections.

Autor: McSweeney, Morgan D.¹ (AUTHOR), Alnajjar, Sarhad² (AUTHOR), Schaefer, Alison M.³ (AUTHOR), Richardson, Zach¹ (AUTHOR), Wolf, Whitney³ (AUTHOR), Stewart, Ian⁴ (AUTHOR), Sriboonyapirat, Pun⁵ (AUTHOR), McCallen, Justin³ (AUTHOR), Farmer, Ellen¹ (AUTHOR), Nzati, Bernadette¹ (AUTHOR), Lord, Sam¹ (AUTHOR), Farrer, Brian¹ (AUTHOR), Moench, Thomas R.¹ (AUTHOR), Kumar, Priya A.^6,7 (AUTHOR), Arora, Harendra⁸ (AUTHOR), Pickles, Raymond J.⁹ (AUTHOR), Hickey, Anthony J.⁴ (AUTHOR), Ackermann, Mark¹⁰ (AUTHOR), Lai, Samuel K.^1,3,9 (AUTHOR) lai@unc.edu

Publikováno v: Advanced Science. 3/27/2024, Vol. 11 Issue 12, p1-12. 12p.

High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies

Autor: Talkington, Anne M., McSweeney, Morgan D., Zhang, Tao, Li, Zibo, Nyborg, Andrew C., LaMoreaux, Brian, Livingston, Eric W., Frank, Jonathan E., Yuan, Hong, Lai, Samuel K.

Publikováno v: In Journal of Controlled Release 10 October 2021 338:804-812

Engineering a "muco‐trapping" ACE2‐immunoglobulin hybrid with picomolar affinity as an inhaled, pan‐variant immunotherapy for COVID‐19.

Autor: Tiruthani, Karthik, Cruz‐Teran, Carlos, Chan, Jasper F. W., Ma, Alice, McSweeney, Morgan, Wolf, Whitney, Yuan, Shoufeng, Poon, Vincent K. M., Chan, Chris C. S., Botta, Lakshmi, Farrer, Brian, Stewart, Ian, Schaefer, Alison, Edelstein, Jasmine, Kumar, Priya, Arora, Harendra, Hutchins, Jeff T., Hickey, Anthony J., Yuen, Kwok‐Yung, Lai, Samuel K.

Publikováno v: Bioengineering & Translational Medicine; Jul2024, Vol. 9 Issue 4, p1-15, 15p

Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

Autor: McSweeney, Morgan D., Price, Lauren S.L., Wessler, Timothy, Ciociola, Elizabeth C., Herity, Leah B., Piscitelli, Joseph A., DeWalle, Alexander C., Harris, Taylor N., Chan, Andy K.P., Saw, Ran Sing, Hu, Peiqi, Jennette, J. Charles, Forest, M. Gregory, Cao, Yanguang, Montgomery, Stephanie A., Zamboni, William C., Lai, Samuel K.

Publikováno v: In Journal of Controlled Release October 2019 311-312:138-146

Accelerated Clearance of Ultrasound Contrast Agents Containing Polyethylene Glycol is Associated with the Generation of Anti-Polyethylene Glycol Antibodies

Autor: Fix, Samantha M. ^*, Nyankima, A. Gloria, McSweeney, Morgan D. ^*, Tsuruta, James K., Lai, Samuel K. ^*, Dayton, Paul A. ^{*, *}

Publikováno v: In Ultrasound in Medicine & Biology June 2018 44(6):1266-1280