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Vulnerability of white matter structure and function to chronic cerebral hypoperfusion and the effects of pharmacological modulation

Autor: McQueen, Jamie

The structural integrity of the white matter is required for neuronal communication within the brain which is essential for normal cognitive function. Post-mortem and clinical imaging studies of elderly individuals have demonstrated that white matter

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.630319

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The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

Autor: McKay, Sean, Ryan, Tomás J., McQueen, Jamie, Indersmitten, Tim, Marwick, Katie F.M., Hasel, Philip, Kopanitsa, Maksym V., Baxter, Paul S., Martel, Marc-André, Kind, Peter C., Wyllie, David J.A., O’Dell, Thomas J., Grant, Seth G.N., Hardingham, Giles E., Komiyama, Noboru H.

Publikováno v: Cell Reports, Vol 25, Iss 4, Pp 841-851.e4 (2018)
Cell Reports

Summary The GluN2 subtype (2A versus 2B) determines biophysical properties and signaling of forebrain NMDA receptors (NMDARs). During development, GluN2A becomes incorporated into previously GluN2B-dominated NMDARs. This “switch” is proposed to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0063ba4560f9088d8dd77bcd01cf78f4
http://www.sciencedirect.com/science/article/pii/S2211124718315602

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

Autor: Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C., Heron, Samuel, Márkus, Nóra M., Mcqueen, Jamie, Hampton, David W., Torvell, Megan, Tiwari, Sachin S., Mckay, Sean, Eraso-pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J. A., Simpson, T. Ian, Hardingham, Giles E.

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Hasel, P, Dando, O, Jiwaji, Z, Baxter, P, Todd, A C, Heron, S, Márkus, N M, Mcqueen, J, Hampton, D W, Torvell, M, Tiwari, S S, Mckay, S, Eraso-pichot, A, Zorzano, A, Masgrau, R, Galea, E, Chandran, S, Wyllie, D J A, Simpson, T I & Hardingham, G E 2017, ' Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism ', Nature Communications, vol. 8, 15132, pp. 1-17 . https://doi.org/10.1038/ncomms15132

The influence that neurons exert on astrocytic function is poorly understood. To investigate this, we first developed a system combining cortical neurons and astrocytes from closely related species, followed by RNA-seq and in silico species separatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::48fa24451ec7b8e7b6cde7b7349ee372
https://doaj.org/article/f17cb8505a5e4abe82484929859194ff